Master Cidofovir with Picmonic for Medicine

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Cidofovir

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Cidofovir is an antiviral medication used to treat CMV retinitis in immunocompromised patients, and it is also indicated for acyclovir-resistant HSV. This drug has a long half-life, and works by preferentially inhibiting viral DNA polymerase. This drug is active, and does not require phosphorylation by viral kinase. A chief side effect of cidofovir use is nephrotoxicity, which can be decreased when cidofovir is coadministered with probenecid and IV saline.

5 KEY FACTS

Cidofovir is used to treat cytomegalovirus (CMV) retinitis in immunocompromised patients.

Cidofovir has proven effective in treating patients with acyclovir-resistant herpes-simplex virus (HSV) infections.

Cidofovir inhibits viral replication by selectively inhibiting viral DNA polymerases. Thus, this drug inhibits viral DNA synthesis during its reproduction cycle.

The major side effect of this medication is nephrotoxicity, which is dose-dependent.

Coadministering probenecid and IV saline with cidofovir decreases the nephrotoxic effects in patients.

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