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Medicine (MD/DO)

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First Aid for the USMLE Step 1 (2023)

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Mesolimbic Pathway (Dopaminergic)

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Mesolimbic Pathway (Dopaminergic)

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6 KEY FACTS

The mesolimbic pathway is one of the four dopaminergic pathways involved in the release of dopamine.

The mesolimbic pathway begins in the ventral tegmental area of the midbrain.

The mesolimbic pathway ends at the nucleus accumbens of the forebrain.

The mesolimbic pathway is responsible for controlling the reward pathway of the brain. This pathway can involve feelings such as positive reinforcement and pleasure.

If there is a defect or inhibition of the mesolimbic pathway, then this can lead to the positive symptoms seen in schizophrenia. These positive symptoms can include delusions, hallucinations, and disorganized speech.

The mesolimbic pathway is the main target of antipsychotic medications used in the treatment of schizophrenia.

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