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Apolipoprotein Types

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Apolipoprotein Types

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Apolipoprotein Types

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12 KEY FACTS

Apolipoproteins are proteins that bind to lipids to form lipoproteins, transporting them in the blood, cerebrospinal fluid, and lymph. ApoE binds to Everything Except LDL. ApoE can bind to chylomicron, chylomicron remnant, VLDL, IDL, and HDL.

ApoE facilitates the uptake of chylomicron remnants and aids in their clearance inside the liver.

ApoAI is found only in HDL.

ApoAI activates LCAT (Lecithin Cholesterol Acyltransferase), which helps in maturing HDL. It is responsible for the esterification of free cholesterol, allowing for a greater amount of cholesterol to be loaded onto the protein.

ApoCII can be seen in chylomicron, VLDL, IDL, and HDL.

ApoCII is a cofactor of lipoprotein lipase that catalyzes cleavage.

ApoB48 binds to chylomicron and chylomicron remnant.

ApoB48 mediates chylomicron secretion from the GI cells into lymphatics, which then continue to the blood.

ApoB48 only can bind to particles originating from the intestine.

ApoB100 binds to VLDL, IDL, and LDL.

B100 binds to the LDL receptor.

ApoB100 only binds to particles originating from the liver.

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