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Gastrointestinal System | Pharmacist (Pharm.D) School Study Aid
Crohn's Disease Assessment
- Diarrhea
- 5-6 per day
- Cramping Abdominal Pain
- Fever
- Weight Loss
- Malabsorption
- Anemia
- Complications
- Obstruction
- Fistulas
2 mins
Crohn's Disease Characteristics
- Terminal Ileum and Colon
- Rectal Sparing
- Transmural Inflammation
- Granulomas
- Skip Lesions
- Cobblestone Mucosa
- Fissures
- Fistulas
- Perianal Disease
- Creeping Fat
- Lymphoid Aggregates
- String Sign on Barium Swallow
2 mins
Crohn's Symptoms and Associations
- Diarrhea
- Malabsorption
- Bile-Wasting
- Pigment Gallstones
- Oxalate Kidney Stones
- Ankylosing Spondylitis
- Erythema Nodosum
- Uveitis
- Migratory Polyarthritis
2 mins
Ulcerative Colitis Characteristics
- Autoimmune
- Mucosal and Submucosal Only
- Rectal Involvement
- Stepwise Lesions
- Friable Pseudopolyp
- Crypt Abscess
- Loss of Haustra
- Lead Pipe Appearance
- Bloody Diarrhea
2 mins
Ulcerative Colitis Associations
- Associations
- Toxic Megacolon
- Colorectal Carcinoma
- Anterior Uveitis
- Pyoderma Gangrenosum
- Ankylosing Spondylitis
- Primary Sclerosing Cholangitis
- P-ANCA
1 min
Diverticulosis and Diverticulitis Assessment
- Diverticulosis
- Outpouching
- Diverticulitis
- Inflamed Diverticula
- Assessment
- Abdominal Pain
- Abdominal Distention
- Flatulence
- Fever
- Rectal Bleeding
- Alternating Constipation and Diarrhea
- Considerations
- Peritonitis
2 mins
Diverticulosis and Diverticulitis Interventions
- Interventions
- High Fiber Diet
- Reduce Intra-abdominal Pressure
- Stool Softeners
- Exercise
- Anticholinergics
- Considerations
- Antibiotics
- Bowel Resection
2 mins
Appendicitis
- Mechanism and Characteristics
- Fecalith leading to obstruction and infection
- Most commonly affects teenagers
- Presentation
- Initial peri-umbilical visceral pain
- Subsequent somatic right lower quadrant pain
- Diagnosis
- Rebound tenderness
- Positive psoas sign
- Pain at McBurney's point
- Leukocytosis
- Fever
- Treatment
- Appendectomy
1 min
Acute Appendicitis Treatment
- Diagnosis
- CT Scan
- Treatment
- Immediate Appendectomy
- NPO
- IV Fluids
- Antibiotics
- Perforation
- Tertiary Intention
- Antibiotics Until Afebrile
2 mins
Peptic Ulcer Disease Assessment
- Mechanism/Cause
- Helicobacter Pylori
- NSAIDs
- Increased Stomach Acid
- Assessment
- Abdominal Pain
- Heartburn (Pyrosis)
- Melena
- Weight Changes
- GI Distress
- Considerations
- Most Commonly in Duodenum
- Duodenal: Pain Relieved by Eating
- Gastric: Pain Caused by Eating
2 mins
Peptic Ulcer Disease Interventions
- Combination Drug Therapy
- Two Antibiotics
- Proton Pump Inhibitor (PPI)
- Decrease Acid Secretion
- Avoid NSAIDs
- Diet and Lifestyle Changes
1 min
Hemochromatosis Signs and Symptoms
- Signs and Symptoms
- Micronodular Cirrhosis
- Hepatocellular Carcinoma
- Diabetes
- Bronze Skin Coloring
- CHF
- Arthropathy
- Testicular Atrophy
- Impotence
2 mins
Hemochromatosis Pathophysiology
- Pathophysiology
- Hemosiderin Deposition
- Autosomal Recessive
- HLA-A3
- Secondary to Transfusion Therapy
- Increase Iron
- Increase Ferritin
- Increased Transferrin Saturation
2 mins
Wilson's Disease Pathophysiology
- Autosomal Recessive
- Mutation in ATP7B gene
- Chromosome 13
- Decrease in Ceruloplasmin
- Inadequate copper excretion
- Liver
- Brain
- Kidney
- Cornea
- Joints
- Treat with Penicillamine
2 mins
Wilson's Disease Symptoms
- Cirrhosis
- Hepatocellular Carcinoma
- Basal Ganglia Degeneration
- Dementia
- Dyskinesia
- Asterixis
- Kayser-Fleischer Rings
- Slit Lamp Exam
- Hemolytic Anemia
2 mins
Carcinoid Syndrome
- Pathophysiology
- Neuroendocrine Cells
- Serotonin
- Appendix
- Diagnosis
- Chromogranin A
- Neuron Specific Enolase
- Dense Core Bodies on EM
- Signs and Symptoms
- Symptoms When Metastasize to Liver
- Flushing
- Wheezing
- Right Heart Murmur
- Diarrhea
4 mins
Colorectal Cancer Assessment
- 3rd Most Common Cancer
- Assessment
- Change in Bowel Habits
- Bowel Obstruction
- Rectal Bleeding
- Anemia
- Weight Loss
- Ascites
- Considerations
- Colonoscopy
- FOBT and FIT
2 mins
Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer)
- Characteristics
- Autosomal Dominant
- Defective DNA Mismatch Repair
- 80% Risk of Colon Cancer Development
- Proximal (Right) Colon
- Type II associated with Endometrial, Ovarian and Skin Cancers
- 3-2-1 Rule
- 3 Relatives with Colon Cancer
- Occurs Across 2 Generations
- 1 Relative Diagnosed < 50 Years Old
- Treatment
- Frequent Screening
- Colectomy
3 mins
Types of Hernias
- Hiatal
- Gastroesophageal Reflux Disease (GERD)
- Inguinal
- Men
- Femoral
- Women
- Incisional
- Umbilical
- Consideration
- Strangulation
1 min
Hernia Interventions
- Reduce Intra Abdominal Pressure
- Avoid Straining and Lifting
- Open Mouth Sneezing
- Excision
- Herniorrhaphy
- Hernioplasty
- Consideration
- Scrotal Support
1 min
Types of Intestinal Obstruction
- Mechanical
- Adhesions
- Hernia
- Volvulus
- Intussusception
- Tumor
- Non-Mechanical
- Mesenteric Artery Occlusion
- Spinal Injury
- Paralytic Ileus
2 mins
Intestinal Obstruction
- Partial/Early Obstruction
- Severe Abdominal Pain
- Vomiting
- High Pitched Bowel Sounds
- Abdominal Distention
- Increased Peristalsis
- Total/Neurogenic Obstruction
- Absent Bowel Sounds
- Paralytic Ileus
1 min
Meckel's Diverticulum
- Pathophysiology
- True Diverticulum
- Vitelline Duct
- Yolk Stalk
- Contain Ectopic Tissue
- Pancreatic And Gastric Mucosa
- Signs and Symptoms
- Hemorrhage
- Intussusceptions
- Volvulus
- Diagnosis
- 2 Feet From Ileocecal Valve
- 2 Inches Long
- 2% Population
- First 2 Years Of Life
- Pertechnetate T99
2 mins
Hirschsprung Disease
- Failure of Neural Crest Cell Migration
- Involves Rectum
- Lack of Auerbach and Meissner Plexus
- Chronic Constipation
- Failure to Pass Meconium
- Congenital Megacolon
- Increased Risk with Down Syndrome
- RET Mutations
2 mins
Imperforate Anus
- Mechanism
- Congenital Anorectal Malformation
- Signs and Symptoms
- No Anal Opening
- Absence of Meconium
- Gradual Increase in Abdominal Distention
- Considerations
- Surgical Repair
- Bowel Management
2 mins
Whipple's Disease
- Tropheryma Whipplei
- Gram-Positive
- Middle-aged, Caucasian men and Farmers
- Malabsorption
- Mesenteric Nodes
- Arthralgias
- Cardiac Symptoms
- Neurologic Symptoms
- PAS-positive Foamy Macrophages
1 min
Celiac Disease Diagnosis and Treatment
- Diagnosis
- Blunting of Intestinal Villi
- Lymphocytes in Lamina Propria
- Anti-gliadin Antibodies (IgA)
- Anti-endomysial Antibodies (IgA)
- Anti-tissue Transglutaminase Antibodies (IgA)
- Treatment
- Gluten-Free Diet
- Corticosteroids
- Dapsone
- Complications
- Intestinal Lymphoma
2 mins
Celiac Disease Characteristics
- Epidemiology
- European Descent
- HLA-DQ2
- HLA-DQ8
- Pathophysiology
- Autoimmune-mediated Intolerance of Gliadin
- Symptoms
- Dermatitis Herpetiformis
- Weight Loss
- Failure to Thrive
- Decreased Bone Density
- Steatorrhea
- Anemia
2 mins
Fistula Causes
- FRIEND Mnemonic
- Foreign Body
- Radiation
- Inflammation or Infection
- Epithelialization
- Neoplasm
- Distal Obstruction
1 min
Mesenteric Ischemia
- Signs and Symptoms
- Severe Abdominal Pain
- Bloody Diarrhea
- Metabolic Acidosis
- Diagnosis
- Increased WBC
- Increased Lactate (Lactic Acid)
- X-ray
- Air Within Bowel Wall
- CT Angiography
- Bowel Wall Edema
- Treatment
- Antibiotics
- Emergent Surgical Intervention
2 mins
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