MK Shared "1aex" - 145 Picmonics
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1aex
Microscopic Polyangiitis
- Pathophysiology
- Necrotizing Small Vessel Vasculitis
- Signs and Symptoms
- Lungs, Kidneys, and Skin Commonly Affected
- Palpable Purpura
- Rapidly Progressive Cresentic Glomerulonephritis
- Diagnosis
- Lesions are Same Age
- Non-granulomatous
- Minimal Nasopharyngeal Involvement
- P-ANCA
- Treatment
- Corticosteroids
- Cyclophosphamide
2 mins
Granulomatosis with Polyangiitis (GPA) Characteristics
- Pathophysiology
- Small Vessel Vasculitis
- Necrotizing
- Lungs and Upper Airway
- Crescentic Glomerulonephritis
- DIAGNOSTICS
- c-ANCA
- X-ray
- Multiple Nodules in Lungs
- Treatment
- Cyclophosphamide
- Corticosteroids
- Rituximab
3 mins
Granulomatosis with Polyangiitis (GPA) Symptoms
- Upper Respiratory Tract
- Saddle Nose
- Perforation of Nasal Septum
- Chronic Sinusitis
- Otitis Media
- Mastoiditis
- Lower Respiratory Tract
- Cough
- Dyspnea
- Hemoptysis
- Kidney
- Rapidly Progressive Glomerulonephritis
- Hematuria
- RBC Casts
2 mins
Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome)
- Pathophysiology
- Granulomatous Vasculitis
- Signs and Symptoms
- Sinusitis
- Skin Lesions
- Peripheral Neuropathy
- Asthma
- GI Disease
- Heart Disease
- Kidney Failure
- Diagnosis
- Eosinophilia
- p-ANCA
- Treatment
- Corticosteroids
4 mins
Henoch-Schonlein Purpura
- Most Common Childhood Vasculitis
- Follows Pharyngeal or Respiratory Infection
- Palpable Purpura on Legs and Buttocks
- Arthralgia
- Intestinal Hemorrhage
- Black Stool (Melena)
- Associated with IgA Nephropathy
2 mins
Polyarteritis Nodosa
- Pathophysiology
- Immune Complex-Mediated Transmural Vasculitis
- Hepatitis B Association
- Fibrinoid Necrosis
- Signs and Symptoms
- Black Stool (Melena)
- Neurologic Dysfunction
- Myalgia
- Fever
- Hypertension
- Diagnosis
- Vessels / Lesions in Different Stages
- Renal Microaneurysms (On Arteriogram)
- Spares Pulmonary Arteries (No Pulmonary Involvement)
- Treatment
- Corticosteroids
- Cyclophosphamide
2 mins
Buerger's Disease
- Pathophysiology
- Thromboangiitis Obliterans
- Segmental Inflammation
- Strong Association with Smoking
- Signs and Symptoms
- Superficial Nodular Phlebitis
- Raynaud's Phenomenon
- Autoamputation
- Treatment
- Smoking Cessation
2 mins
Kawasaki Disease
- Pathophysiology
- Prevalent in Asian Children
- Necrotizing Vasculitis
- Signs and Symptoms
- Fever
- Strawberry-Red Tongue and Mucosa
- Lymphadenopathy
- Desquamative Skin Rash
- Erythema and Edema of the Hands and Feet
- Conjunctivitis
- Coronary Aneurysm
- Treatment
- Intravenous Immunoglobulin (IVIG)
- Aspirin
2 mins
Temporal Arteritis
- Giant Cell Arteritis
- Granulomatous
- Old Females
- Clinical Features
- Polymyalgia Rheumatica
- Unilateral Headache
- Jaw Claudication
- Blindness
- Lab Findings
- Increased ESR
- Normal Serum Creatine Kinase
- Treatment
- Steroids
2 mins
Takayasu Arteritis
- Pathophysiology
- Granulomatous Thickening of Aortic Arch
- Pulseless Disease
- Asian Females
- Signs and Symptoms
- Fever
- Myalgia
- Night Sweats
- Arthritis
- Ocular Disturbances
- Diagnosis
- Increased ESR
- Different Blood Pressures in Arms
2 mins
Nephritic Syndrome
- Inflammatory
- Hematuria
- RBC casts
- Increased Nitrogen in blood
- Oliguria
- Hypertension
- Proteinuria < 3.5 grams per day
2 mins
Rapidly Progressive Glomerulonephritis
- Pathogenesis
- Nephritic Syndrome
- Crescent Shape
- Crescents Consist of Fibrin and C3b
- With Parietal Cells, Monocytes, and Macrophages
- IMMUNOFLUORESCENCE
- Linear Immunofluorescence
- Negative Immunofluorescence
- Granular Immunofluorescence
- Etiology
- Goodpasture Syndrome
- Granulomatosis with Polyangiitis (Formerly Wegener's)
- Microscopic Polyangiitis
- Prognosis
- Poor Prognosis
3 mins
Post Streptococcal Glomerulonephritis
- Pathophysiology
- Nephritic
- Children
- Signs and Symptoms
- Edema
- Cola Colored Urine
- Follows Group A Streptococcal pharyngitis or Skin Infection
- Diagnosis
- Neutrophils
- Immunofluorescence (IF) Granular
- Lumpy Bumpy Appearance on Immunofluorescence (IF)
- Subepithelial Immune Complex Humps
2 mins
Berger's Disease (IgA Nephropathy)
- Nephritic
- IgA Nephropathy
- Immune Complex Deposit in Mesangium
- Increased Synthesis of IgA
- Most Common Cause of Nephritic Syndrome
- Overlapping Features with Henoch–Schönlein Purpura
- Presents with Pharyngitis, URI or Acute Gastroenteritis
1 min
Alport Syndrome
- Pathophysiology
- Nephritic
- X-linked
- Mutation in Type IV Collagen
- Diagnosis
- Split Basement Membrane
- Basket Weave Appearance
- Signs and Symptoms
- Ocular Disorders
- Deafness
2 mins
Nephrotic Syndrome
- Signs and Symptoms
- Massive Proteinuria > 3.5g per Day
- Edema
- Increased risk of infection
- Thromboembolism
- Hyperlipidemia
- Fatty casts
1 min
Membranous Glomerulonephritis
- Characteristics
- Nephrotic
- Diagnosis
- LM Thickening of Capillary and Glomerular Basement Membrane (GBM)
- EM Spike and Dome Appearance with Subepithelial Deposits
- IF Granular
- Primary
- Phospholipase A2 Receptor Autoantibodies
- Secondary
- NSAIDS
- Gold
- Solid Tumors
- Hepatitis B Virus (HBV)
- Lupus
3 mins
Minimal Change Disease
- Pathophysiology
- Nephrotic
- Most Common in Children
- May be Triggered by Recent Infection or Immune Stimulus
- Diagnosis
- On Electron Microscopy (EM) See Foot Process (Podocyte) Effacement
- On Light Microscopy (LM) See Normal Glomeruli
- Loss of Negative Charge
- Selective Loss of Albumin
- Treatment
- Responds to Corticosteroids
2 mins
Focal Segmental Glomerulosclerosis
- Most Common Cause of Nephrotic Syndrome in Hispanic People and African Americans
- Associated with Sickle Cell Disease and HIV
- Associated Interferon Therapy and Heroin Abuse
- Histopathology
- LM Segmental Sclerosis and Hyalinosis
- EM Focal Damage of Visceral Epithelial Cells
- IF Negative
- Signs & Symptoms
- Microscopic Hematuria
- Nonselective Proteinuria
- Considerations
- Poor Prognosis
2 mins
Membranoproliferative Glomerulonephritis
- Nephritic-Nephrotic Syndrome
- Type I
- Subendothelial Immune Complexes
- Hepatitis C Virus
- Granular IF
- Tram Tracks Caused by Splitting of the GBM
- Ingrowth of Mesangium
- Type II
- Dense Deposit Disease
- C3 Nephritic Factor
2 mins
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