Anthony Shared "Pharm-Antimicrobials-Protein" - 17 Picmonics
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Pharm-Antimicrobials-Protein
Aminoglycosides
- Drug Names
- Gentamicin
- Neomycin for Bowel Surgery Prep
- Amikacin
- Tobramycin
- Streptomycin
- Mechanism of Action
- Bactericidal
- Inhibit Formation of Initiation Complex
- Cause Misreading of mRNA
- Require O2 for Uptake
- Resistance
- Resistance by Transferase Enzymes
- Acetylation
- Phosphorylation
- Adenylation
- Indications
- Gram-Negative Rod Infections
- Synergistic with B-Lactam Antibiotics
- Side Effects
- Nephrotoxicity Especially When Used with Cephalosporins
- Ototoxicity Especially When Used with Loop Diuretics
- Teratogen
5 mins
Aminoglycoside Side Effects
- Side Effects
- Ototoxicity
- Nephrotoxicity
- Respiratory Paralysis
- Contraindications
- Pregnancy
- Considerations
- Peak and Trough
- Never Mix with Penicillin in Same IV
2 mins
Neomycin Sulfate
- Mechanism
- Aminoglycoside Antibiotic
- Indications
- Topical Infection
- Intestinal Surgery Prophylaxis
- Side Effects
- Ototoxicity
- Nephrotoxicity
- Rash
- Blood Dyscrasias
- Considerations
- GI Superinfection
2 mins
Chloramphenicol
- Mechanism
- Bacteriostatic
- Inhibits 50S Peptidyltransferase Activity
- Indications
- Meningitis
- Rocky Mountain Spotted Fever in Pregnant Women
- Side Effects
- Anemia
- Aplastic Anemia
- Gray Baby Syndrome due to Decreased UDP-Glucuronyl Transferase
- Resistance Caused by Plasmid Encoded Acetyltransferase
2 mins
Protein Synthesis Inhibitors
- Drug Names
- 30S inhibitors
- Aminoglycosides
- Tetracyclines
- 50S inhibitors
- Chloramphenicol
- Clindamycin
- Erythromycin
- Lincomycin
- Linezolid
3 mins
Clindamycin
- Mechanism of Action
- Bacteriostatic
- Binds 50S Ribosomal Subunit
- Blocks Translocation
- Indications
- Anaerobic Infections above the Diaphragm
- Aspiration Pneumonia
- Lung Abscess
- Side Effects
- Can Cause Pseudomembranous Colitis
1 min
Tetracycline Drug Names and Indications
- Drug Names
- Demeclocycline
- Minocycline
- Doxycycline
- Fecally Eliminated
- Can be Used in Renal Failure
- Indications
- Antidiuretic Hormone Antagonist
- Chlamydia
- Rickettsia
- Borrelia burgdorferi
- Helicobacter Pylori
- Mycoplasma Pneumonia
3 mins
Tetracycline Mechanism
- Binds to 30 S to Prevent Attachment of Aminoacyl tRNA
- Limited CNS Penetration
- Divalent Cations Inhibit Absorption
- Must Not Take with Milk, Antacids, Iron
1 min
Tetracycline Toxicities
- Inhibition of Bone Growth in Children
- Teratogen
- Discoloration of Teeth
- Photosensitivity
- GI Distress
2 mins
Macrolides
- Mechanism of Action
- Bacteriostatic
- Bind to 23S rRNA of 50S Subunit
- Inhibit Protein Synthesis by Blocking Translocation
- Macrolides
- Erythromycin
- Azithromycin
- Clarithromycin
- Indications
- Gram-Positive Cocci
- Atypical Pneumonia
- Chlamydia
- Considerations
- Resistance by Methylation of 23S rRNA Binding
2 mins
Macrolides Side Effects
- Side Effects
- Diarrhea
- Prolonged QT Interval
- P450 Inhibitor
- Cholestatic Hepatitis
- Skin Rash
- Eosinophilia
3 mins
Hypertrophic Pyloric Stenosis (HPS) Assessment
- Mechanism
- Hypertrophied Pylorus
- Risk Factor
- Macrolide Use
- Assessment
- 3-6 Weeks of Age
- Projectile Vomiting After Feeding
- No Pain or Discomfort
- Weight Loss
- Dehydration
- Hungry Baby
- Olive Mass
2 mins
Fanconi Syndrome Causes
- Hereditary Causes
- Cystinosis
- Dent's Disease
- Wilson's Disease
- Oculocerebrorenal (Lowe) Syndrome
- Galactosemia
- Hereditary Fructose Intolerance
- Glycogen Storage Diseases
- Tyrosinemia
- Acquired and Medication Causes
- Tenofovir
- Heavy Metals
- Expired Tetracyclines
- Cisplatin
- Gentamycin (Aminoglycosides)
- Valproate Sodium
- Multiple Myeloma
2 mins
Legionella Disease
- Signs and Symptoms
- High Fever
- Diarrhea
- Increased Liver Enzymes
- Hyponatremia
- Type IV Renal Tubular Acidosis
- Severe Atypical Pneumonia
- Pontiac Fever
- Treatment
- Fluoroquinolones
- Macrolides
2 mins
Neisseria gonorrhoeae Disease
- Signs & Symptoms
- Dysuria
- Pelvic Inflammatory Disease (PID)
- Fitz-Hugh-Curtis Syndrome
- Neonatal Conjunctivitis
- Pharyngitis
- Septic Arthritis
- Tenosynovitis
- Pustules On Hands And Feet
- Treatment
- Ceftriaxone
- Azithromycin
- Doxycycline
- Considerations
- C5-9 Complement Deficiency (Recurrent Infections)
2 mins
Mycoplasma Pneumoniae
- Characteristics
- No Cell Wall and No Gram Stain
- Cholesterol Membrane
- Eaton's Agar
- Mulberry Colonies
- Disease
- Atypical pneumonia
- Military Recruits
- Cold IgM Autoimmune Hemolytic Anemia
- Erythema Multiforme
- Treatment
- Tetracycline
- Erythromycin
2 mins
Clostridioides difficile (Clostridium difficile)
- Characteristics
- Gram-Positive
- Bacillus
- Anaerobe
- Clindamycin and Ampicillin
- Toxin A Enterotoxin
- Damages Brush Border of Gut
- Toxin B Cytotoxin
- Damages Cytoskeletal Structure
- Signs and Symptoms
- Diarrhea
- Pseudomembranous Colitis
- Toxic Megacolon
- Diagnosis
- Detect Toxins in Stool
- Treatment
- Metronidazole
- Vancomycin
3 mins
