Mareli Shared "Path: GI, Lymphoma, Leukemia" - 37 Picmonics
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Path: GI, Lymphoma, Leukemia
Burkitt's Lymphoma
- Adolescents or young adults
- C-myc gene moves next to heavy chain Ig gene
- T 8;14
- Starry sky appearance
- Sheets of lymphocytes with interspersed macrophages
- Jaw lesion in endemic (African) form
- Pelvis or abdomen in non endemic form (American form)
- Associated with EBV
2 mins
Diffuse Large B Cell Lymphoma
- Epidemiology
- Most Common Non-Hodgkin’s Lymphoma
- Usually in Older Adults
- 20% in Children
- Features
- May be Mature T Cell in Origin
- Derives from Germinal Center
- GI Tract and Brain
2 mins
Follicular Lymphoma
- Derives from Germinal Center
- Occurs in adults
- T14;18
- BCL 2 overexpression
- BCL 2 inhibits apoptosis
- Indolent
- Generalized lymphadenopathy
- Bone marrow involvement
2 mins
Mantle Cell Lymphoma
- Older Males
- Activation of Cyclin D Gene
- T 11;14
- CD5
- Poor Prognosis
55 secs
Adult T Cell Lymphoma
- Caused by HTLV 1
- Japan, West Africa, Caribbean
- Present with cutaneous lesions
- Aggressive
1 min
Mycosis Fungoides / Sézary Syndrome
- Mechanism
- Neoplastic CD4+ Cells
- Adults 40 - 60 Years Old
- Mycosis Fungoides
- Neoplastic CD4+ Cells Infiltrate Skin
- Rashes Or Plaques
- Pautrier's Abscesses
- Sézary Syndrome
- Neoplastic CD4+ Spread from Skin to Systemic Involvement
- Sézary Cells With "Cerebriform Nuclei"
2 mins
Non-Hodgkin's Lymphoma Assessment
- Cause
- Lymphatic Cancer
- Non-Contiguous Spread
- B or T Cells
- Assessment
- Painless Lymphadenopathy
- Constitutional B Signs
- Night Sweats
- Fever
- Weight Loss
- Mediastinal or Abdominal Mass
- Considerations
- Older Adults
- > 60 Subtypes
2 mins
Hodgkin Lymphoma Pathophysiology
- Pathophysiology
- Reed-Sternberg Cells
- Binucleate
- Owl's Eyes Appearance
- CD 15 and CD 30
- B Cell Origin
- Bimodal Age Distribution
2 mins
Hodgkin Lymphoma Signs & Symptoms
- Signs and Symptoms
- Localized Single Group of Lymph Nodes
- Contiguous Spread
- Constitutional B Symptoms
- Low-Grade Fever
- Night Sweats
- Weight Loss
2 mins
Types of Intestinal Obstruction
- Mechanical
- Adhesions
- Hernia
- Volvulus
- Intussusception
- Tumor
- Non-Mechanical
- Mesenteric Artery Occlusion
- Spinal Injury
- Paralytic Ileus
2 mins
Types of Hernias
- Hiatal
- Gastroesophageal Reflux Disease (GERD)
- Inguinal
- Men
- Femoral
- Women
- Incisional
- Umbilical
- Consideration
- Strangulation
1 min
Intussusception
- Pathophysiology
- Telescoping of Bowel Segments
- Lead Point
- Assessment
- Episodic Abdominal Pain
- Diarrhea
- Sausage-Shaped Mass
- Red Currant Jelly Stools
- Diagnosis
- Ultrasound/CT
- Target Sign
- Considerations
- More Common in Children
- Rotavirus Vaccine Contraindicated
- Management
- Air or Hydrostatic Enema
- Surgical Reduction
3 mins
Intestinal Obstruction
- Partial/Early Obstruction
- Severe Abdominal Pain
- Vomiting
- High Pitched Bowel Sounds
- Abdominal Distention
- Increased Peristalsis
- Total/Neurogenic Obstruction
- Absent Bowel Sounds
- Paralytic Ileus
1 min
Cystic Fibrosis Mechanisms
- Autosomal Recessive
- CFTR Chromosome 7
- Cl- channel Defect
- Decreased Chloride Secretion
- Increased Na and Water Reabsorption
- Increased Na and Cl in Sweat
- Dehydration of Mucous Layers
2 mins
Cystic Fibrosis Symptoms and Complications
- Recurrent Pulmonary Infections
- Chronic Bronchitis
- Nasal Polyps
- Pancreatic Insufficiency
- Intestinal Obstruction
- Malabsorption and Diarrhea
- Vitamin Deficiencies
- Chronic Hepatic Disease
- Infertility in Males
1 min
Celiac Disease Characteristics
- Epidemiology
- European Descent
- HLA-DQ2
- HLA-DQ8
- Pathophysiology
- Autoimmune-mediated Intolerance of Gliadin
- Symptoms
- Dermatitis Herpetiformis
- Weight Loss
- Failure to Thrive
- Decreased Bone Density
- Steatorrhea
- Anemia
2 mins
Celiac Disease Diagnosis and Treatment
- Diagnosis
- Blunting of Intestinal Villi
- Lymphocytes in Lamina Propria
- Anti-gliadin Antibodies (IgA)
- Anti-endomysial Antibodies (IgA)
- Anti-tissue Transglutaminase Antibodies (IgA)
- Treatment
- Gluten-Free Diet
- Corticosteroids
- Dapsone
- Complications
- Intestinal Lymphoma
2 mins
Whipple's Disease
- Tropheryma Whipplei
- Gram-Positive
- Middle-aged, Caucasian men and Farmers
- Malabsorption
- Mesenteric Nodes
- Arthralgias
- Cardiac Symptoms
- Neurologic Symptoms
- PAS-positive Foamy Macrophages
1 min
Irritable Bowel Syndrome (IBS) Assessment
- Abdominal Pain
- Relieved by Defecation
- Alternating Diarrhea and Constipation
- Fatigue
- Excessive Flatulence
- Sensation of Incomplete Evacuation
- Considerations
- Stressors
- Food Intolerances
- More Common in Women
- Rule Out Other Disorders
2 mins
Crohn's Disease Characteristics
- Terminal Ileum and Colon
- Rectal Sparing
- Transmural Inflammation
- Granulomas
- Skip Lesions
- Cobblestone Mucosa
- Fissures
- Fistulas
- Perianal Disease
- Creeping Fat
- Lymphoid Aggregates
- String Sign on Barium Swallow
2 mins
