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Inflammation and Neoplasia - Cellular Adaptations
Hypertrophic Cardiomyopathy Mechanisms
Pathophysiology
2/3 Autosomal-Dominant
1/3 Sporadic Type
Mutation in Gene for Sarcomere Protein
Cardiac Myosin Binding Protein C
Asymmetric Septal Hypertrophy
Outflow Tract Obstruction
Diastolic Dysfunction
2 mins
Benign Prostatic Hyperplasia (BPH) Disease
Mechanism and Characteristics
DHT-induced Growth Factors
Common in Men > 50 Years Old
Smooth, Symmetric, Firm Enlargement
Affects Lateral and Middle (Periurethral) Gland
Urethra Compression
Symptoms and Complications
Increased Urinary Frequency
Nocturia
Dysuria
Urinary Tract Infection
Hydronephrosis
1 min
Barrett's Esophagus
Histological findings
Metaplasia in Lower Esophagus
Columnar Epithelium
Associated Pathologies
Gastroesophageal Reflux Disease (GERD)
Esophagitis
Esophageal Ulcers
Increased Risk of Esophageal Adenocarcinoma
1 min
Helicobacter Pylori
Characteristics
Gram-Negative
Bacilli
Curved
Polar Flagellum
Catalase-Positive
Oxidase-Positive
Disease
Gastric and Duodenal Ulcers
Ammonia
Neutral Environment
Gastric Adenocarcinoma
MALT lymphoma
Diagnosis
Serology IgG antibody
Stool Antigen
Urease Positive Breath Test
Biopsy
Treatment
2 ABX and PPI
2 mins
Developmental Dysplasia of the Hip
Cause
Abnormal Femoral Head in Acetabulum
Newborn Assessment
Positive Barlow Sign
Clicking with Adduction
Positive Ortolani Sign
Clicking with Abduction
Asymmetrical Limb Lengths and Folds (Gluteal and Thigh)
Older Child Assessment
Trendelenburg Sign
Interventions
Abduction Device
Pavlik Harness
Closed Reduction
3 mins
Cervical Cancer Assessment
Cause/Mechanism
Human Papillomavirus (HPV)
Assessment
Metrorrhagia
Leukorrhea
Pain
Abnormal Pap Test
May Be Asymptomatic
Considerations
HPV Vaccine
2 mins
Open-Angle Glaucoma
Humor Has Access to Trabecular Meshwork
Presentation
Painless
African American
Elderly
Positive Family History
Primary Open-Angle Glaucoma
Most Common Form of Glaucoma
Unknown Mechanism
Secondary Open-Angle Glaucoma
Blocked Trabecular Meshwork (With Open-Angle)
WBCs
Red Blood Cells (RBC)
Retinal Products
2 mins
Types of Malignant Melanoma
Superficial Spreading
Most Common Cause of Melanoma
Nodular
Aggressive and Rapidly Arising
Acral-Lentiginous
Males
Asians and African Americans
Lentigo Maligna
Geographic Shape
Sun Exposed Areas
2 mins
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