Michael Shared "Copy of Endo Exam 9" - 36 Picmonics
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Copy of Endo Exam 9
Polycystic Ovarian Syndrome (PCOS) Mechanism
- Mechanism
- Hyperinsulinemia Increases GnRH Pulse Frequency
- Large Increase in LH
- Small Decrease in FSH
- Increased Androgen Production From Theca-Lutein Cells
- Decreased Steroid Hormone-Binding-Globulin (SHBG) Causes Increased Free Testosterone
- Obese Patients Have Increased Estrogen
- Increased Risk of Endometrial Cancer
2 mins
Polycystic Ovarian Syndrome (PCOS) Symptoms and Diagnosis
- Symptoms
- Most Common Cause of Infertility in Women
- Amenorrhea
- Acne
- Hirsutism
- Obesity
- Diagnosis
- Enlarged, Cystic Ovaries
- LH:FSH Ratio of 3:1
- "String of Pearls" on Ultrasound
1 min
Polycystic Ovarian Syndrome (PCOS) Treatment
- Weight Loss
- Oral Contraceptives
- Clomiphene Citrate
- Anti-androgens
- Cyclic Progesterone for Endometrial Protection
- Metformin
1 min
Sheehan's Syndrome
- Postpartum Pituitary Gland Necrosis
- Agalactorrhea
- Amenorrhea
- Secondary Hypothyroidism with Cold Intolerance
1 min
Turner Syndrome
- Signs and Symptoms
- Female (XO)
- Short stature
- Shield Chest
- Cystic Hygroma (Webbing of Neck)
- Lymphedema in Hands and Feet
- Ovarian Dysgenesis
- Streak Ovary
- Decreased Estrogen
- Increased FSH
- Increased LH
- Dysgerminoma
- Bicuspid Aortic Valve
- Preductal Coarctation of the Aorta
- Horseshoe Kidney
- Menopause before Menarche
- Amenorrhea
5 mins
Steroid Hormones
- Characteristics
- Nuclear Membrane
- Long-Lived and Slow-Acting
- Cholesterol-Derived
- Intracellular Receptors
- DNA Transcription
- Examples
- Testosterone
- Aldosterone
- Estrogen
- Cortisol
2 mins
Leuprolide
- Mechanism
- GnRH Agonist (Pulsatile Use)
- GnRH Antagonist (Continuous Use)
- Upregulates FSH And LH
- Downregulates FSH And LH
- Indications Pulsatile
- Infertility
- Indications Continuous
- Prostate Cancer
- Precocious Puberty
- Uterine Fibroids
- Endometriosis
- Side Effects
- Anti-androgenic Effects
2 mins
Androgen Insensitivity (Complete)
- Defect in Androgen Receptor
- Phenotypically Female
- (46, XY)
- Female External Genitalia
- Rudimentary Vagina
- Scant Sexual Hair
- Testes Often in Labia Majora
- Testes Surgically Removed to Prevent Malignancy
- Increased Estrogen, Testosterone, and LH
- Absent Uterus and Fallopian Tubes
3 mins
Aromatase Inhibitors
- Indications
- Estrogen Receptor-positive (ER+) Breast Tumors
- Systemic Metastases
- Drugs
- Reversible, non-steroid
- Letrozole
- Anastrozole
- Irreversible, steroid
- Exemestane
- Side Effects
- Osteoporosis
- Arthritis
1 min
Tamoxifen
- Mechanism of Action
- Selective Estrogen Receptor Modulator (SERM)
- Antagonist on Breast Tissue
- Indications
- ER-positive Breast Cancer
- Side Effects
- Decreased Risk of Osteoporosis
- Increased Risk of Endometrial Cancer
- Increased Risk of Venous Thromboembolism (VTE)
1 min
Ovulatory Hormones I - Follicular Phase
- Characteristics
- 0-14 Days
- GnRH Stimulates FSH and LH
- Follicle Secretes Estrogen
- Negative Feedback from Estrogen
- Increased Estrogen Leads to Positive Feedback
- FSH and LH Surge
- LH Spike Leads to Ovulation
2 mins
Ovulatory Hormones II - Luteal Phase
- Days 15-28
- Corpus Luteum
- Secretes Progesterone
- Negative Feedback inhibits FSH and LH
- No pregnancy forms Corpus Albicans
- Stops Estrogen Secretion
- Endometrial Sloughing - Menses
- GnRH secretion produces new follicular phase
2 mins
5 Alpha Reductase Deficiency
- Autosomal Recessive
- Inability to Convert Testosterone to DHT
- Normal Internal Genitalia
- Ambiguous External Genitalia until Puberty
- Masculinization During Puberty with Growth of External Genitalia
- LH can be Increased
- Normal Estrogen, LH, and Testosterone levels
2 mins
Testes
- Characteristics
- FSH Stimulates Sertoli Cells
- Inhibin B Release
- LH Stimulates Leydig Cells
- Leydig Cells Secrete Testosterone
- Testosterone Causes Male Development
2 mins
Klinefelter's Syndrome
- Pathophysiology
- Male (XXY)
- Signs and Symptoms
- Eunuchoid Body Shape
- Gynecomastia and Female Hair Distribution
- Testicular Atrophy
- Dysgenesis of Seminiferous Tubules
- Possible Developmental Delay
- Hypogonadism
- Decreased Inhibin B
- Increased FSH
- Abnormal Leydig Cell Function
- Decreased Testosterone
- Increased LH
- Increased Estrogen
- Barr body (inactivated X chromosome)
6 mins
Spironolactone (Aldactone)
- Mechanisms
- Inhibition of Aldosterone
- Potassium Retention
- Indications
- Hypertension
- Edema
- Heart Failure
- Side Effects
- Hyperkalemia
- Endocrine Effects
- Consideration
- Avoid Potassium Supplements
2 mins
Varicocele
- Pathophysiology
- Dilation of Pampiniform Plexus Veins
- Signs and Symptoms
- Soft Left-Sided Scrotal Mass
- Bag of Worms
- Increased Size with Standing or Valsalva
- Decreased Size while Supine
- Testicular Atrophy
- Subfertility
- Diagnosis
- Ultrasound
- Retrograde Venous Flow
- Treatment
- Surgical Gonadal Vein Ligation
- Scrotal Support
3 mins
Spermatogenesis
- Seminiferous Tubules
- Sertoli Cells
- Spermatogonia
- Mitosis
- Primary Spermatocyte
- Meiosis I
- Secondary Spermatocyte
- Meiosis II
- Spermatid
- Spermatozoa
- Acrosome
- Flagellum
2 mins
Oogenesis
- Characteristics
- Primary Oocytes From Birth
- Meiosis I Once a Month
- Secondary Oocyte Plus Polar Body
- Frozen in Metaphase II, in Meiosis II
- Ovulation
- Fertilization by Sperm
- Meiosis II
- Ovum
- Zygote Forms
2 mins
17 Alpha Hydroxylase Deficiency
- Decreased Cortisol
- Decreased Sex Hormones
- Increased Mineralocorticoids (DOC)
- Hypertension
- Hypokalemia
- XY Externally Phenotypic Female
- No Internal Reproductive Structures Due to Mullerian Inhibitory Factor
- XX Externally Phenotypic Female
- Sexual Infantilism
2 mins
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