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pharmacology
Antimuscarinic Antidote
Antidote
Physostigmine Salicylate
44 secs
Direct Cholinomimetics
Muscarinic Agonists
Bethanechol
Bladder and Bowels
Methacholine
Bronchoconstriction
Pilocarpine
Contracts Ciliary Muscle and Pupillary Sphincter
Carbachol
Releases Intraocular Pressure
1 min
Indirect Cholinomimetics
Acetylcholinesterase Inhibitors
Doesn't Cross BBB
Edrophonium
Myasthenia Gravis (Diagnosis)
Pyridostigmine and Neostigmine
Myasthenia Gravis (Tx)
Ileus
Crosses BBB
Physostigmine
Atropine Overdose
Glaucoma
Donepezil
Alzheimer's
2 mins
Acetylcholinesterase Inhibitor Poisoning
DUMBBELSS
Diarrhea
Urination
Miosis
Bronchospasm
Bradycardia
Emesis
Lacrimation
Salivation
Sweating
2 mins
Acetylcholinesterase Inhibitor Antidote
Antidote
Atropine
Pralidoxime
1 min
Atropine
Indications
Blocks DUMBBeLSS
Bradycardia
Side Effects
Skin Flushing
Increased Temperature
Dry Mouth
Cycloplegia
Disorientation
Mydriasis
1 min
Nondepolarizing Neuromuscular Blocking Drugs
Names Include "Cur"
Competitive Antagonists
Acetylcholine Competition
Reversal of Blockade
Neostigmine, Edrophonium
1 min
Succinylcholine
Indications
Inducing Paralysis
Mechanism of Action
Neuromuscular Blocking Drugs
Motor Nicotinic Receptor
ACh Receptor Agonist
Depolarization
Phases of Action
Phase I (Paralysis Non-reversible)
Phase II (Paralysis Reversible)
Neostigmine (Reversal Agent)
2 mins
Norepinephrine (Levophed)
Mechanism of Action
Alpha Agonist
Beta-1 Agonist
Indications
Severe Hypotension
Side Effect
Decreases Renal Blood Flow
Arrhythmias
Hypertension
Considerations
Tissue Necrosis
Last Resort Medication
2 mins
Epinephrine (Adrenaline)
Mechanism
Alpha and Beta Agonist
Indications
Anaphylaxis
Primary Open Angle Glaucoma (POAG)
Bleeding
Cardiac Arrest
Side Effects
Tachycardia
Hypertension
Tremors
Insomnia
Considerations
Multiple Strengths
2 mins
Nonselective Alpha-Blockers
Indications
Phentolamine
Reversible
Pheochromocytoma (Diagnosis)
Hypertensive Crisis
Phenoxybenzamine
Pheochromocytoma (Treatment)
Side Effects
Orthostatic Hypotension
Reflex Tachycardia
2 mins
Selective Alpha-1 Blockers
"-osin" suffix
Mechanism of Action
Blocks Alpha1 Receptors
Indications
Hypertension
Benign Prostatic Hyperplasia (BPH)
Side Effects
Syncope
Orthostatic Hypotension
1 min
Selective Alpha-2 Blockers
Mirtazapine
Indications
Depression Treatment
Mechanism of Action
Blocks Alpha2 Receptor
Antagonist at 5-HT receptors
Side Effects
Sedation
Weight gain
Increased Serum Cholesterol
1 min
Beta Blocker Antidote
Antidote
Glucagon
29 secs
Beta-1 Agonists
Dobutamine
Heart Failure
Cardiac Stress Test
Isoproterenol
Bradyarrhythmias
Torsades de Pointes
1 min
Beta-2 Agonists
Short-term Treatment
Terbutaline
Asthma
Tocolysis
Albuterol
Asthma
Long-term Treatment
Salmeterol
Asthma
Chronic Obstructive Pulmonary Disease (COPD)
3 mins
Cardiovascular Effects of Beta-Blockers
Cardiac Myocytes and Vasculature
Decrease cAMP
Decreases SA and AV Node Conduction Velocity
Lower Blood Pressure
Decrease O2 Consumption
Decreases Mortality Post-MI
2 mins
Nonselective Beta-Blockers
"-olol" Suffix
Nonselective
Propranolol
Timolol
Nadolol
Partial β Agonist
Pindolol
Nonselective β with α Blocking
Carvedilol
Labetalol
2 mins
Systemic Effects of Beta-Blockers
Respiratory
Bronchoconstriction
Metabolic
Decreased Insulin
Decreased Glycolysis and Lipolysis
Eye
Reduces Intraocular Pressure
1 min
Nitroglycerin
Indications
Pulmonary Edema
Angina
Mechanism of Action
Decreases Preload
Releases NO in Blood
Side Effects
Hypotension
Reflex Tachycardia
Flushing
Monday Disease
Contraindications
Viagra (Sildenafil)
2 mins
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