Marissa Shared "B&L Chemo Meds" - 15 Picmonics
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B&L Chemo Meds
Mechlorethamine
- Alkylating Agent
- Cross-Links DNA
- Vesicant
- Sodium Thiosulfate
- Alopecia
- Myelosuppression
- Teratogenic
- Menstrual Irregularities
32 secs
Cyclophosphamide
- Mechanism
- Requires Bioactivation by Liver
- Cross-links DNA
- Guanine N7 Position
- Indications
- Autoimmune Disorders
- Leukemia
- Lymphoma
- Solid Tumors
- Side Effects
- Myelosuppression
- Hemorrhagic Cystitis
- Prevent with Mesna
3 mins
Nitrosoureas
- Carmustine
- Lomustine
- Alkylating Agent
- Cross blood-brain barrier
- Pulmonary Fibrosis
- Nephrotoxicity
- Hepatotoxicity
- Myelosuppression
Methotrexate
- Indications
- Rheumatoid Arthritis
- Cancer
- Medical Abortion
- Mechanism
- Folic Acid Analog
- Inhibits Dihydrofolate Reductase
- Side Effects
- Pulmonary Fibrosis
- Myelosuppression is Treated with Leucovorin Rescue (Folinic Acid)
- Macrocytic Anemia
- Hepatitis
- Teratogenic
- Mucositis
2 mins
Cytarabine
- Antimetabolite
- Pyrimidine analog
- Inhibits DNA elongation
- S-phase Specific
- Ataxia
- Myelosuppression
- Depo-cytarabine
6-Mercaptopurine
- Hypoxanthine analog
- Pro-drug
- Inhibits transcription and replication
- Inhibits IMP to AMP
- Hyperuricemia
- Renal Calculi
- Allopurinol
- Antimetabolite
- S-phase Specific
Cladribine
- Antimetabolite
- Competes with dATP
- Induces PARP
- Rash
- Dividing and non-dividing cells
- Nelarabine
Vincristine (Oncovin)
- Mechanism
- Vinca Alkaloid
- Inhibits Microtubules
- Indications
- Leukemias
- Lymphomas
- Side Effects
- Peripheral Neuropathy
- Paralytic Ileus
- Considerations
- Vesicant
2 mins
Etoposide
- Indications
- Small Cell Lung Cancer
- Testicular Cancer
- Mechanism of Action
- Inhibits Topoisomerase II
- Errors in DNA Synthesis Cause Apoptosis
- Side Effects
- Myelosuppression
- Alopecia
- Hypotension
- Nausea and Vomiting
2 mins
Doxorubicin (Adriamycin)
- Indications
- Solid Tumors
- Lymphomas and Leukemias
- Mechanism
- Free Radical Production
- Intercalates DNA
- Prevents Double Helix from Sealing
- Side Effect
- Cardiotoxicity
- Dexrazoxane Decreases Toxicity
1 min
Bleomycin
- Indications
- Testicular Cancer
- Hodgkin's Lymphoma
- Mechanism of Action
- Induces Free Radical Formation
- Breaks in DNA Strands
- Side Effects
- Pulmonary Fibrosis
- Skin Changes
- Mucositis
1 min
L-Aspariginase
- Inhibits protein synthesis
- Anaphylaxis
- Hyperglycemia
- Bleeding
- PEG-aspariginase
- Non-allergenic
Imatinib (Gleevec)
- Indications
- Chronic Myelogenous Leukemia (CML)
- Inhibitor of BCR-ABL Tyrosine Kinase
- Caused by Philadelphia Chromosome
- GI Stromal Tumors
- Inhibitor of C-kit Tyrosine Kinase
- Toxicity
- Fluid Retention
1 min
Hydroxyurea
- Mechanism
- Inhibits Ribonucleotide Reductase
- Decreased DNA Synthesis
- S-phase Specific
- Indications
- Melanoma
- Chronic Myelogenous Leukemia (CML)
- Sickle Cell Disease
- Through Increased HbF (Fetal Hemoglobin)
- Side Effects
- Myelosuppression
- GI Distress
2 mins
Misc Antineoplastics
- Arsenic trioxide
- DNA fragmentation
- Cardiac abnormalities
- Bortezomib
- Proteasome inhibitor
- Peripheral neuropathy
- Vorinostat
- HDAC inhibitor
- G1 Phase
- Hyperglycemia
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