OnlineMedEd Shared "Antibacterials - Antimycobacterial" - 7 Picmonics
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Antibacterials - Antimycobacterial
Isoniazid
- Indications
- Tuberculosis (TB)
- Mechanism of Action
- Requires Catalase Peroxidase
- Decreases Mycolic Acid Synthesis
- Fast vs Slow Acetylators
- Side Effects
- B6 Deficiency
- Neurotoxicity
- Hepatotoxicity
- Drug-induced Lupus
1 min
Isoniazid (INH)
- Mechanism
- Interferes with DNA Metabolism
- Indications
- Tuberculosis (TB)
- Side Effects
- Optic Neuritis
- Nausea and Vomiting
- Hepatotoxicity
- Peripheral Neuropathy
- Considerations
- Vitamin B6 Prophylaxis
- Monitor AST/ALT
2 mins
Rifampin
- Tuberculosis (TB)
- Blocks RNA Polymerization
- Haemophilus influenzae Type B
- Leprosy
- Meningitis
- P450 inducer
- Red-orange urine
55 secs
Ethambutol (Myambutol)
- Mechanisms
- Inhibits RNA Synthesis
- Bacteriostatic
- Indications
- Tuberculosis (TB)
- Side Effects
- Optic Neuritis
- Red/Green Color Blindness
- Gouty Arthritis
- Consideration
- Monitor Vision Acuity
2 mins
Ethambutol
- Mechanism of Action
- Bacteriostatic
- Blocks Arabinosyltransferase
- Arabinosyltransferase Polymerizes Carbohydrates
- Carbohydrate Polymers Make Mycobacterium TB Cell Wall
- Side Effects
- Red/Green Color Blindness
- Reversible with Drug Discontinuation
40 secs
Mycobacterium Tuberculosis Characteristics
- Characteristics
- Mycolic Acid Cell Wall
- Acid-fast
- Carbolfuchsin Stain Red
- Lowenstein-Jensen Agar
- Serpentine Cord Factor
- Primary TB
- Primary TB
- Caseating Granuloma
- Ghon Focus
- Hilar Lymph Nodes
- Ghon Complex
- Reactivation TB
- Reactivation TB
- Reactivation in Apex
3 mins
Mycobacterium leprae
- Characteristics
- Acid-Fast
- Aerobic
- Likes Cool Temperature
- Diagnosis by Skin Biopsy or PCR
- Lepromatous Leprosy
- Th2 Response
- Leonine Facies
- Tuberculoid Leprosy
- TH1 Response
- Hypoesthetic Skin Plaques
- Granulomatous Response
- Treatment
- Dapsone
- Rifampin
- Clofazimine
2 mins
