Skender Shared "Step 1: First Biochemistry Deck" - 133 Picmonics
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Step 1: First Biochemistry Deck
Hydroxyurea
Mechanism
Inhibits Ribonucleotide Reductase
Decreased DNA Synthesis
S-phase Specific
Indications
Melanoma
Chronic Myelogenous Leukemia (CML)
Sickle Cell Disease
Through Increased HbF (Fetal Hemoglobin)
Side Effects
Myelosuppression
GI Distress
2 mins
Azathioprine (Imuran)
Mechanism
Antimetabolite
Prodrug of 6-mercaptopurine (6-MP)
Inhibits Synthesis of Nucleic Acids
Indications
Autoimmune Disorders
Kidney Transplantation
Side Effects
Myelosuppression
Increased Toxicity with Allopurinol Use
Pancreatitis
Malignancy
3 mins
Fluorouracil (5-FU)
Mechanism
Antimetabolite
"Thymine-less Death"
Indications
Slow-growing Solid Tumors
Co-administered with Leucovorin for Stomach Cancer
Basal Cell Carcinoma (Topical)
Side Effects
Myelosuppression
Mucositis
Severe Diarrhea
3 mins
Methotrexate
Indications
Rheumatoid Arthritis
Cancer
Medical Abortion
Mechanism
Folic Acid Analog
Inhibits Dihydrofolate Reductase
Side Effects
Pulmonary Fibrosis
Myelosuppression is Treated with Leucovorin Rescue (Folinic Acid)
Inhibit Nucleotide Binding to Reverse Transcriptase
Chain Termination
Require Phosphorylation
1 min
NRTI Toxicity
Bone Marrow Suppression
Reverse with G-CSF and Erythropoietin
Rash
Neuropathy
Anemia
Pancreatitis
Lactic Acidosis
1 min
Dactinomycin (Actinomycin D)
Indications
Wilms' Tumor
Rhabdomyosarcoma
Ewing's Sarcoma
Gestational Trophoblastic Malignancy
Mechanism
Intercalates DNA
Side Effect
Myelosuppression
1 min
Rifampin
Tuberculosis (TB)
Blocks RNA Polymerization
Haemophilus influenzae Type B
Leprosy
Meningitis
P450 inducer
Red-orange urine
55 secs
Systemic Lupus Erythematosus (SLE) Diagnosis and Clinical Features
IM DAMN SHARP acronym
Immunoglobulins
Malar rash
Discoid rash
Antinuclear antibody
Mucositis
Neurologic disorders
Serositis
Hematologic disorders
Arthritis
Renal disorders
Photosensitivity
2 mins
Systemic Lupus Erythematosus (SLE) Mechanism, Treatment and Complications
Mechanism and Characteristics
Systemic Autoimmune Disease
9:1 female to male ratio
Treatment
Glucocorticoids
NSAIDS
Hydroxychloroquine
Cyclophosphamide
Complications
Lupus nephritis
Libman-Sacks Endocarditis
Secondary Antiphospholipid Antibody Syndrome
Other
Drug-induced lupus
2 mins
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