Janani Shared "Z pharm/path" - 21 Picmonics
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Z pharm/path
Arsenic Poisoning
- Symptoms/Findings
- Vomiting
- Rice-water stools
- Garlic breath
- Can be found in Pesticides and Contaminated water
- Carcinogen
- Angiosarcoma
- Lung Cancer
- Squamous Cell Carcinoma of the Lung
- Treatment
- Dimercaprol
- Succimer
Lead Antidotes
- Antidotes
- Dimercaprol
- CaEDTA
- Succimer
39 secs
Cyanide Toxicity
- Mechanism
- Impedes Oxidative Phosphorylation
- Lactic Acidosis
- Metabolic Acidosis
- Symptoms
- Skin Flushing
- Tachycardia
- Tachypnea
- Vomiting
- Change In LOC (Altered Mental Status)
- Seizures
- Coma
- Treatment
- Hydroxocobalamin
- Sodium Thiosulphate
- Nitrates
Psammoma Bodies
- PSaMMoma
- Papillary Carcinoma of the Thyroid
- Serous Papillary Cystadenocarcinoma of the Ovary
- Meningioma
- Malignant Mesothelioma
Methemoglobinemia
- Methemoglobinemia
- Fe3+
- chocolate colored blood
- Caused by sulfa, nitrate, or benzocaine
- Can treat cyanide poisoning
- Antidote is methylene blue and vitamin c
Pure Red Cell Aplasia
- Anemia
- White cell and platelet counts w/ in normal limits
- IgG autoantibodies
- Thymoma
- Cytotoxic T Lymphocytes
- Parvovirus B19
Good syndrome
- Good syndrome
- Thymoma
- hypogammaglobulinemia
Polycythemia Paraneoplastic
- Renal Cell Carcinoma
- Hemangioblastoma
- Hepatocellular carcinoma
- Pheochromocytoma
- Uterine Fibroids
Teratoma
- Germ-cell Tumor
- Dermoid Cyst (Benign and Mature Teratoma)
- Immature Teratoma (Malignant)
- Struma Ovarii
2 mins
Paraneoplastic cerebellar degeneration
- Paraneoplastic cerebellar degeneration
- Anti Hu = small cell lung cancer
- Anti-Yo = breast/gyn cancer
- Anti-tr = hodgkin lymphoma
- In purkinje cells
- Paraneoplastic encephalomyelitis can be caused by anti Hu as well
Hematogenous spreading carcinomas
- Follicular thyroid carcinoma
- choriocarcinoma
- renal cell carcinoma
- hepatocellular carcinoma
Ingested Seafood Toxins
- Inhibits Depolarization (blocks Na channels)
- Block Depolarization
- Tetrodotoxin
- Saxitoxin (dinoflagellates in red tide)
- PERSISTENT DEPOLARIZATION (Binds Na channels)
- Persistent depolarization
- Ciguatoxin (exotic fish, moray eel, barracuda, snapper)
- Batrachotoxin (South American Frogs)
- Histamine release
- Scombroid poisoning (spoiled dark meat fish, tuna, mahi mahi, mackerel, bonito)
Clomiphene
- Clomiphene Citrate
- Infertility
- PCOS
- Estrogen Antagonist at hypothalamus
- estrogen antagonist
- Hypothalamus
- Side Effects
- Hot Flashes
- Visual Disturbances
- Multiple Gestations
- Ovarian Torsion
Tacrolimus (Prograf) Overview
- Mechanisms
- Immunosuppressant
- Inhibits Calcineurin, Decreasing IL-2
- Indications
- Transplant Rejection
- Atopic Dermatitis
- Considerations
- Increased Lymphoma Risk
- Avoid Grapefruit Juice
1 min
Tacrolimus (Prograf) Side Effects
- Nephrotoxicity
- Neurotoxicity
- GI Distress
- Infection
- Hypertension
- Hyperkalemia
- Hyperglycemia
1 min
RNA
- Characteristics
- mRNA
- 3' Poly A Tail
- 5' Cap
- Template For Translation
- rRNA
- Catalyzes Amino Acid Bonds
- Component of Ribosome Enzyme
- tRNA
- Anticodon Region
- 3' Tail Bind To Amino Acid
2 mins
Hydroxyurea
- Mechanism
- Inhibits Ribonucleotide Reductase
- Decreased DNA Synthesis
- S-phase Specific
- Indications
- Melanoma
- Chronic Myelogenous Leukemia (CML)
- Sickle Cell Disease
- Through Increased HbF (Fetal Hemoglobin)
- Side Effects
- Myelosuppression
- GI Distress
2 mins
Cyclosporine (Sandimmune) Overview
- Mechanism
- Immunosuppressant
- Inhibits Calcineurin, Decreasing IL-2
- Indications
- Prevent Transplant Rejection
- Psoriasis
- Rheumatoid Arthritis
- Considerations
- Monitor Plasma Levels
- Avoid Grapefruit Juice
- Increased Risk of Lymphoma
2 mins
Cyclosporine (Sandimmune) Side Effects
- Side Effects
- Nephrotoxicity
- Hepatotoxicity
- Infection
- Hypertension
- Hirsutism
- Tremor
- Hyperkalemia
- Hypomagnesemia
- Gingival Hyperplasia
1 min
disulfiram like reactions (DELETED)
- Disulfiram like reaction with alcohol
- Metronidazole
- Cephalosporins
- Griseofulvin
- 1st Generation Sulfonylureas
- procarbazine
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