Amanda Shared "Unit 2 - Pharm/ Immuno" - 29 Picmonics
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Unit 2 - Pharm/ Immuno
Alpha 1 Receptor
- Characteristics
- Gq Subunit
- Increase Vascular Smooth Muscle Contraction
- Increase Pupillary Dilator Muscle Contraction
- Increase Intestinal and Bladder Sphincter Muscle Contraction
1 min
Alpha 2 Receptor
- Characteristics
- Gi Subunit
- Decrease Sympathetic Outflow
- Decrease Insulin Release
- Decrease Lipolysis
- Increase Platelet Aggregation
- Decrease Aqueous Humor Production
2 mins
Beta-1 Receptor
- Characteristics
- Gs Protein Class
- Increased Heart Rate
- Increased Contractility
- Increase Renin Release
- Increased Lipolysis
44 secs
Beta-2 Receptor
- Characteristics
- Gs protein class
- Increased Heart Rate
- Increased Contractility
- Increased Lipolysis
- Increased Insulin
- Increased Aqueous Humor Production
- Ciliary Muscle Relaxation
- Vasodilation
- Bronchodilation
- Decrease Uterine Tone
2 mins
Inflammatory Response
- Pathogens Infect Tissue
- Mast Cells Release Histamine
- Histamine Dilates and Increases Capillary Permeability
- Macrophages Engulf Pathogens
- Macrophage Signals Cells With Cytokines
- Responding Neutrophils Cross Capillary Wall
- B And T Lymphocytes Arrive At Injury Site
2 mins
Innate Immunity Barriers
- Skin Protects Against Pathogens
- Normal Flora Outcompete Pathogens
- Lysozyme in Saliva, Tears, and Mucus
- Mucous Traps Pathogens
- Cilia Remove Mucus
- Acid and Digestive Enzymes in the Stomach Kill Pathogens
2 mins
Humoral Adaptive Immunity
- Characteristics
- B Cell Binds Free Floating Antigen
- B Cell Presents Antigen to Helper T Cell
- Helper T Cells Help B Cells Develop Antigen Specificity
- Plasma B Cells Secrete Antibodies
- Memory B Cells Cause Faster Secondary Response
2 mins
Innate Immunity Cellular Response
- Characteristics
- Natural Killer Lymphocytes Attack Abnormal Cells
- Neutrophils in Blood
- Infected Cells Release Interferon
- Complement Proteins Lyse Pathogens/Infected Cells
- Dendritic Cells in Tissue
- Macrophages in Tissue
2 mins
Cell-mediated Adaptive Immune Response
- Characteristics
- Macrophages and Dendritic Cells Present Antigens
- T Cell Develops Antigen Specificity
- Regulatory T Cells Suppress Response
- Memory T Cells Cause Faster Secondary Response
- Cytotoxic T Cells Lyse Infected Cells
- Infected Cells Present Antigen On Surface
2 mins
Immune System Tissues
- Characteristics
- Bone Marrow
- B Cells and T Cells Formed
- B Cells Mature
- Thymus
- T Cells Tested For Self-Response
- T Cells Mature
- Lymph Nodes
- Mature B Cells and T Cells Monitor Lymph For Pathogens
- Spleen
- Mature B Cells and T Cells Monitor Blood For Pathogens
1 min
Cell Surface Proteins - B Cells
- Ig
- CD19
- CD20
- CD21
- CD40
- MHC II
- B7
1 min
Acute Myelogenous Leukemia (AML)
- Myeloblasts Increase on Peripheral Smear
- Median Onset 60 Years
- T 15;17 M3 Subtype
- Auer Rods
- Disseminated Intravascular Coagulation (DIC) is a Common Presentation
- M5 Gum Infiltration
- Responds to Vitamin A
3 mins
Chronic Myelogenous Leukemia (CML)
- Pathophysiology
- BCR-ABL
- 9;22 Translocation
- Philadelphia Chromosome
- Signs & Symptoms
- Tyrosine Kinase
- Low Alkaline Phosphatase
- Splenomegaly
- Considerations
- Blast Crisis
- Age 30 to 90 Years
- Responds to Imatinib
3 mins
Acute Lymphoblastic Leukemia (ALL)
- Ages < 15
- May Present with Bone Marrow Involvement in Children
- Mediastinal Mass in Adolescents
- TdT Positive
- CALLA Positive
- t(12;21) Better Prognosis
- Spread to CNS and Testes
- Most Responsive to Chemotherapy
2 mins
Chronic Lymphocytic Leukemia (CLL)
- Signs and Symptoms
- Age > 60 Years
- B Cell Neoplasm
- Smudge Cells
- Often Asymptomatic
- Cold IgM Autoimmune Hemolytic Anemia
- Warm IgG Autoimmune Hemolytic Anemia
- Richter's Transformation
3 mins
Hairy Cell Leukemia
- Pathophysiology
- Mature B Cell Tumor
- Signs and Symptoms
- Splenomegaly
- Diagnosis
- Flow Cytometry
- Cells Have Filamentous Hair-Like Projections
- Stains TRAP Positive
- Dry Tap on Bone Marrow Aspiration
- Treatment
- Cladribine
- Pentostatin
2 mins
Leukemia Assessment
- Cause
- Immature WBCs
- Assessment
- Recurrent Infections
- Easy Bruising
- Bleeding
- Anemia
- Fatigue
- Weight Loss
- Bone Pain
- Considerations
- May Have Normal or High WBC Count
2 mins
Leukemia Interventions
- Diagnosis
- Bone Marrow Aspiration
- X-Rays
- Interventions
- Chemotherapy
- Bleeding Precautions
- Neutropenic Precautions
- Strict Asepsis
- Bone Marrow Transplant
- Blood Transfusions
- Monitor Temperature Elevations
- Adequate Nutrition
- Imatinib (Gleevec) for Chronic Myelogenous Leukemia (CML)
3 mins
Burkitt's Lymphoma
- Adolescents or young adults
- C-myc gene moves next to heavy chain Ig gene
- T 8;14
- Starry sky appearance
- Sheets of lymphocytes with interspersed macrophages
- Jaw lesion in endemic (African) form
- Pelvis or abdomen in non endemic form (American form)
- Associated with EBV
2 mins
Follicular Lymphoma
- Derives from Germinal Center
- Occurs in adults
- T14;18
- BCL 2 overexpression
- BCL 2 inhibits apoptosis
- Indolent
- Generalized lymphadenopathy
- Bone marrow involvement
2 mins
