Austin Shared "Step" - 120 Picmonics
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Step
MEN 1 (Multiple Endocrine Neoplasia)
- Pathophysiology
- Autosomal Dominant
- Menin Mutation (Tumor Suppression Gene)
- Chromosome 11
- Signs and Symptoms
- Pancreatic Endocrine Tumors
- Pituitary Tumors
- Parathyroid Adenomas
2 mins
MEN 2A (Multiple Endocrine Neoplasia)
- Pathophysiology
- Autosomal Dominant
- RET Gene
- Signs and Symptoms
- Medullary Thyroid carcinoma
- Calcitonin
- Parathyroid
- Pheochromocytoma
45 secs
MEN 2B (Multiple Endocrine Neoplasia)
- Pathophysiology
- RET Gene
- Autosomal Dominant
- Signs and Symptoms
- Medullary Thyroid Carcinoma
- Pheochromocytoma
- Mucosal Neuromas
- Marfanoid Body Habitus
2 mins
Choriocarcinoma
- Germ-cell tumor
- Trophoblastic tissue
- Hematogenous spread to lungs
- Malignant
- Theca-lutein cysts
- Hydatidiform Mole
- hCG
59 secs
Fibromas
- Non-germ cell tumor
- Meigs Syndrome
- Thecoma
- Pulling sensation in groin
- Spindle-shaped fibroblasts
44 secs
Ovarian Cystadenoma
- Non-germ cell tumor
- Serous
- Unilocular
- Bilateral
- Mucinous
- Multilocular
- Benign
- Most Common
49 secs
Ovarian Cystadenocarcinoma
- Non-germ Cell Tumor
- Mucinous
- Peritoneal Spread
- Serous
- Psammoma Bodies
- Bilateral
- Malignant
- Stromal Invasion
- CA 125
- BRCA-1 and Lynch Syndrome
1 min
Wilson's Disease Pathophysiology
- Autosomal Recessive
- Mutation in ATP7B gene
- Chromosome 13
- Decrease in Ceruloplasmin
- Inadequate copper excretion
- Liver
- Brain
- Kidney
- Cornea
- Joints
- Treat with Penicillamine
2 mins
Wilson's Disease Symptoms
- Cirrhosis
- Hepatocellular Carcinoma
- Basal Ganglia Degeneration
- Dementia
- Dyskinesia
- Asterixis
- Kayser-Fleischer Rings
- Slit Lamp Exam
- Hemolytic Anemia
2 mins
Craniopharyngioma
- Hypopituitarism
- Remnants of Rathke's Pouch
- Tooth-enamel Like Calcification
- Cholesterol Crystals
- Yellow Viscous Fluid
- Headache
- Bitemporal Hemianopsia
1 min
Pilocytic Astrocytoma
- Occurs Most Commonly in Kids
- Posterior Fossa
- Cerebellum
- Well Circumscribed
- GFAP
- Rosenthal Fibers
- Eosinophilic Corkscrew Fibers
1 min
Ependymoma
- Occur in Children
- Fourth Ventricle
- Hydrocephalus
- Perivascular Pseudorosettes
- Rod Shaped Blepharoplasts
- Cauda Equina in Adults
- Poor Prognosis
- Neurofibromatosis Type II
2 mins
Transplant Rejection
- Hyperacute
- Occurs within Minutes
- Antibody Mediated Due to Preformed Antidonor Antibodies
- Acute
- Occurs within Weeks
- Cytotoxic T Lymphocytes Cause Cell-mediated or Antibody-mediated Response
- Chronic
- Occurs Months to Years Later
- Antibody and T Cell-mediated Vascular Damage
2 mins
Paget's Disease of Bone
- Pathophysiology
- Men > Age 40
- Increased Osteoblast and Osteoclast activity
- Mosaic Pattern
- Signs and Symptoms
- Increased Skull Diameter
- Hearing Loss
- Fractures
- Bone Ache and Joint Pain
- High Output Heart Failure
- Diagnosis
- Bone Scan
- Normal Parathyroid hormone (PTH) and Calcium
- Elevated ALP
- Treatment
- Bisphosphonate
- Calcitonin
2 mins
Hypersensitivity Type I
- Previous Antigen Exposure
- Immediate Reaction
- IgE Cross-linking
- Presensitized Mast Cells
- Histamine Release
- Vasodilation
- Anaphylaxis
- Allergies
- Treatment
- Epinephrine
1 min
Hypersensitivity Type II
- Cytotoxic
- IgM or IgG antibody-mediated
- Membrane Attack Complex (MAC)
- Mechanism
- Opsonization
- Complement Activation
- NK Cells
- Testing
- Direct Coombs test
- Indirect Coombs Test
1 min
Hypersensitivity Type III
- Immune Complex
- Antigen-antibody (IgG) complex activates complement
- Neutrophils release lysozomal enzymes
- Examples
- Arthus Reaction
- Serum Sickness
- Systemic Lupus Erythematosus (SLE)
1 min
Hypersensitivity Type IV
- Delayed-Type Hypersensitivity
- T Cell Mediated
- Antibody Independant
- Macrophages Activated
- Examples
- Transplant Rejection
- PPD Skin Test
- Contact Dermatitis
1 min
Ulcerative Colitis Associations
- Associations
- Toxic Megacolon
- Colorectal Carcinoma
- Anterior Uveitis
- Pyoderma Gangrenosum
- Ankylosing Spondylitis
- Primary Sclerosing Cholangitis
- P-ANCA
1 min
Ulcerative Colitis Characteristics
- Autoimmune
- Mucosal and Submucosal Only
- Rectal Involvement
- Stepwise Lesions
- Friable Pseudopolyp
- Crypt Abscess
- Loss of Haustra
- Lead Pipe Appearance
- Bloody Diarrhea
2 mins
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