Ryan Shared "B4 Path 1" - 15 Picmonics
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B4 Path 1
Microscopic Polyangiitis
- Pathophysiology
- Necrotizing Small Vessel Vasculitis
- Signs and Symptoms
- Lungs, Kidneys, and Skin Commonly Affected
- Palpable Purpura
- Rapidly Progressive Cresentic Glomerulonephritis
- Diagnosis
- Lesions are Same Age
- Non-granulomatous
- Minimal Nasopharyngeal Involvement
- P-ANCA
- Treatment
- Corticosteroids
- Cyclophosphamide
2 mins
Granulomatosis with Polyangiitis (GPA) Characteristics
- Pathophysiology
- Small Vessel Vasculitis
- Necrotizing
- Lungs and Upper Airway
- Crescentic Glomerulonephritis
- DIAGNOSTICS
- c-ANCA
- X-ray
- Multiple Nodules in Lungs
- Treatment
- Cyclophosphamide
- Corticosteroids
- Rituximab
3 mins
Granulomatosis with Polyangiitis (GPA) Symptoms
- Upper Respiratory Tract
- Saddle Nose
- Perforation of Nasal Septum
- Chronic Sinusitis
- Otitis Media
- Mastoiditis
- Lower Respiratory Tract
- Cough
- Dyspnea
- Hemoptysis
- Kidney
- Rapidly Progressive Glomerulonephritis
- Hematuria
- RBC Casts
2 mins
Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome)
- Pathophysiology
- Granulomatous Vasculitis
- Signs and Symptoms
- Sinusitis
- Skin Lesions
- Peripheral Neuropathy
- Asthma
- GI Disease
- Heart Disease
- Kidney Failure
- Diagnosis
- Eosinophilia
- p-ANCA
- Treatment
- Corticosteroids
4 mins
Henoch-Schonlein Purpura
- Most Common Childhood Vasculitis
- Follows Pharyngeal or Respiratory Infection
- Palpable Purpura on Legs and Buttocks
- Arthralgia
- Intestinal Hemorrhage
- Black Stool (Melena)
- Associated with IgA Nephropathy
2 mins
Kawasaki Disease
- Pathophysiology
- Prevalent in Asian Children
- Necrotizing Vasculitis
- Signs and Symptoms
- Fever
- Strawberry-Red Tongue and Mucosa
- Lymphadenopathy
- Desquamative Skin Rash
- Erythema and Edema of the Hands and Feet
- Conjunctivitis
- Coronary Aneurysm
- Treatment
- Intravenous Immunoglobulin (IVIG)
- Aspirin
2 mins
Kawasaki Disease
- Prevalent In Asian Children
- Necrotizing Vasculitis
- fever
- Erythema And Edema Of The Hands And Feet
- Conjunctivitis
- Aspirin
- t cell mediated
- Coronary Aneurysm
- Myocardial Infarction
Kawasaki (mnemonic: CRASH BURN)
- Acute (0-2wks)
- Labs: normochromic anemia, leukocytosis with left shift
- Elevated ESR&CRP
- subacute (2-8wks)
- Gradual decline in ESR&CRP
- Labs: thrombocytosis
- Untreated children develop coronary artery aneurysms
- ECHO (at diagnosis for baseline, at 2 weeks, at 8 weeks)
- chronic (>8wks)
- Begins when all clinical symptoms have disappeared
- Treatment
- high dose aspirin
- IVIG (Intravenous Immunoglobulin)
- Low dose aspirin for 6wks
- Chronic Anticoagulation (if aneurysm present) with aspirin or other antiplatelet medications
- Corticosteroids ONLY if refractory to IVIG
Buerger's Disease
- Pathophysiology
- Thromboangiitis Obliterans
- Segmental Inflammation
- Strong Association with Smoking
- Signs and Symptoms
- Superficial Nodular Phlebitis
- Raynaud's Phenomenon
- Autoamputation
- Treatment
- Smoking Cessation
2 mins
Buerger Disease
- Thromboangiitis obliterans
- Segmental inflammation
- Smoking
- Raynauds phenomenon
- Autoamputation
- luminal thrombosis
- histology
- Superficial nodular phlebitis
- location
- Necrotizing Vasculitis
polyarteritis nodosa
- Cyclophosphamide
- pearls
- young adults
- Fatal If Not Treated
Polymyalgia Rheumatica
- Symptoms
- Shoulder and hip pain and stiffness
- Fever
- General Malaise
- Weight loss
- No muscular weakness
- Women over 50
- Temporal (giant cell) Arteritis
- Low-dose corticosteroids
Temporal Arteritis
- Giant Cell Arteritis
- Granulomatous
- Old Females
- Clinical Features
- Polymyalgia Rheumatica
- Unilateral Headache
- Jaw Claudication
- Blindness
- Lab Findings
- Increased ESR
- Normal Serum Creatine Kinase
- Treatment
- Steroids
2 mins
Takayasu Arteritis
- Pathophysiology
- Granulomatous Thickening of Aortic Arch
- Pulseless Disease
- Asian Females
- Signs and Symptoms
- Fever
- Myalgia
- Night Sweats
- Arthritis
- Ocular Disturbances
- Diagnosis
- Increased ESR
- Different Blood Pressures in Arms
2 mins
Takayasu Arteritis
- Pulseless Disease
- Women under 40
- Ocular Disturbances
- Granulomatous vasculitis
- Granulomatous Thickening Of Aortic Arch
- luminal narrowing
- Asian Females
- all layers
- brain ischemia
- Pulmonary Hypertension
- Myocardial Infarction
- Renal Insufficiency
