Peter Shared "Endocrine" - 472 Picmonics
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Endocrine
Hypothalamus
- Characteristics
- Anterior Pituitary Stimulated Through the Hypophyseal Portal
- GHRH
- GnRH
- TRH
- PIF
- CRF Released During Stress
- Posterior Pituitary Stimulated Through Neural Control
3 mins
Peptide Hormones
- Characteristics
- Fast-Acting and Short-Lived
- Bind To Cell Membrane Receptors
- Stimulate Secondary Messengers
- Amino Acid-Derived
- Examples
- Insulin
- Parathyroid Hormone (PTH)
- Vasopressin
- Oxytocin
2 mins
Pharyngeal Arch Derivatives: 1st Arch
- Cartilage
- Meckel's Cartilage
- Mandible
- Malleus
- Incus
- Sphenomandibular Ligament
- Muscles
- Muscles of Mastication
- Tensor Tympani
- Tensor Veli Palatini
- Anterior Belly of the Digastric
- Mylohyoid
- Nerves
- CN V2
- CN V3
- Conditions
- Treacher Collins Syndrome
3 mins
Pharyngeal Arch Derivatives: 2nd Arch
- Cartilage
- Reichert's Cartilage
- Stapes
- Styloid Process
- Lesser Horn of Hyoid
- Stylohyoid Ligament
- Muscles
- Muscles of Facial Expression
- Stapedius
- Stylohyoid
- Platysma
- Posterior Belly of Digastric
- Nerves
- CN VII
- Conditions
- Congenital Pharyngocutaneous Fistula
2 mins
Pharyngeal Arch Derivatives: 3rd Arch
- Cartilage
- Greater Horn of Hyoid
- Muscles
- Stylopharyngeus
- Nerves
- CN IX (Glossopharyngeal)
- Arteries
- Common Carotid
- Internal Carotid
1 min
Pharyngeal Arch Derivatives: 4-6 Arches
- Cartilage
- Thyroid
- Cricoid
- Arytenoids
- Corniculate
- Cuneiform
- Muscles
- 4th: Cricothyroid
- 4th: Pharyngeal Constrictors
- 6th: Intrinsic Muscles of Larynx
- Nerves
- 4th: CN X (Vagus Nerve)
- Superior Laryngeal Branch
- 6th: CN X (Vagus Nerve)
- Recurrent Laryngeal Branch
2 mins
Branchial Pouches: 1st Pouch
- Endoderm Lines the Auditory Tube
- Middle Ear Cavity
- Eustachian Tube
- Mastoid Air Cells
1 min
Branchial Pouches: 2nd Pouch
- Palatine Tonsils
38 secs
Branchial Pouches: 3rd Pouch
- Separates into Dorsal and Ventral Wings
- Dorsal Wings
- Inferior Parathyroid Glands
- Ventral Wings
- Thymus
1 min
Branchial Pouches: 4th Pouch
- Separates into Dorsal and Ventral Wings
- Dorsal Wings
- Superior Parathyroid Glands
- Ventral Wings
- Parafollicular (C) Cells of Thyroid Gland
- Formed by Endoderm
1 min
Posterior Pituitary
- Characteristics
- Neuroendocrine Reflex Stimulation (By Hypothalamus)
- Direct Hormones
- Vasopressin
- Increased Water Retention (In Kidneys)
- Oxytocin
- Increased Uterine Contraction
- Mammary Glands Contraction
2 mins
Collecting Duct
- Characteristics
- Na+ Reabsorption
- Vasopressin Causes Water reabsorption
- Concentrates Filtrate
2 mins
Low Blood Pressure Response
- Characteristics
- Posterior Pituitary Releases Vasopressin
- Vasoconstriction
- Adrenal Cortex Releases Aldosterone
- Increased Na+ and H2O Reabsorption
1 min
Distal Tubule
- Characteristics
- Hormonally Regulated
- Aldosterone Causes Na+ Reabsorption
- Na+ Reabsorbed Via Active Transport
- Water follows Na+
- Parathyroid Hormone Causes Ca2+ Reabsorption
- Leads to Collecting Duct
1 min
Desmopressin (DDAVP)
- Synthetic vasopressin (ADH)
- Binds V2 (renal and endothelial cells)
- renal
- Central Diabetes Insipidus
- Nocturia
- Bed Wetting (Nocturnal enuresis)
- Heme
- Stimulates Weibel-Palade bodies (endothelial cell)
- Von Willbrand factor
- Factor VIII
- Von Willebrand Disease
- Hemophilia A (factor 8 def)
- Thrombocytopenia
- Uremia (platelet aggregation)
- Side Effects
- Hyponatremia (fluid retention)
- Nausea and Vomiting
- Seizures
- Confusion / Lethargy
Von Willebrand Disease
- Mixed platelet and coagulation disorder
- Mechanism
- Autosomal Dominant Condition Leading to Reduced vWF
- Defect in platelet plug formation
- Labs
- Increased Bleeding Time
- PTT increased
- Factor VIII decreased
- Normal platelet count
- Treatment
- DDAVP (synthetic vasopressin)
1 min
Hemophilia A, B, C
- X-linked Recessive
- A: Low Factor 8
- Hemarthrosis, Intramuscular Hematoma, Intracerebral Hemorrhage
- Mgmt: DDAVP + aminocaproic acid (anti-fibrinolytic)
- B: Low Factor 9
- C: Low Factor 11 | Autosomal Recessive
- Increased PTT (Intrinsic) ONLY
- Complications: Hemosiderin deposition, fibrosis
Syndrome of Inappropriate Antidiuretic Hormone (SIADH) Pharmacologic Interventions
- Diuretics
- Hypertonic IV Fluids
- Demeclocycline
- Tolvaptan and Conivaptan
1 min
Syndrome Of Inappropriate Antidiuretic Hormone (SIADH)
- Pathophysiology
- Hypersecretion of ADH
- Increased Sensitivity to ADH
- Signs & Symptoms
- Serum Hypoosmolality
- Coma and Seizure
- Dilutional Hyponatremia
- Cramps and Tremors
- Euvolemia
- Change in LOC
2 mins
Diabetes Insipidus Assessment
- Polyuria
- Nocturia
- Low Specific Gravity (USG)
- Polydipsia
- Dehydration
- Hypotension
- Tachycardia
- Confusion
2 mins
