Allie Shared "M2. Pharm Antiretrovirals" - 11 Picmonics
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M2. Pharm Antiretrovirals
HIV Prophylaxis Medications
- CD4+ < 200
- TMP-SMX
- Pneumocystis Pneumonia
- CD4+ < 100 Susceptible to Toxoplasma Gondii
- CD4+ < 50
- Mycobacterium Avium and Intracellulare
- Azithromycin If Delayed Therapy
2 mins
HIV CD4+ 500
- Signs and Symptoms
- Candida albicans (Oral Thrush)
- Kaposi's Sarcoma (HHV-8)
- Human Papillomavirus (HPV)
- Epstein-Barr Virus (Oral Hairy Leukoplakia)
3 mins
HIV CD4+ 200
- Signs and Symptoms
- Herpes Simplex Virus (HSV)
- JC Virus
- Progressive Multifocal Leukoencephalopathy (PML)
- Pneumocystis Pneumonia
- (HIV) Dementia
- Histoplasmosis
3 mins
HIV CD4+ 100
- Signs and Symptoms
- Aspergillus fumigatus
- Cryptococcus neoformans
- Candida albicans (Esophagitis)
- Mycobacterium avium complex (MAC)
- Cytomegalovirus (CMV)
- Epstein-Barr virus (EBV) B-cell lymphoma
- Toxoplasma gondii
- Cryptosporidium
- Bartonella henselae
5 mins
HAART
- HIV
- Begin at Diagnosis
- 3 Drugs
- 2 NRTIs (Nucleoside Reverse Transcriptase Inhibitors)
- And one of the following:
- NNRTI (Non-Nucleoside Reverse Transcriptase Inhibitor)
- or Protease Inhibitor
- or Integrase Inhibitor
1 min
NRTIs (Nucleoside Reverse Transcriptase Inhibitors)
- Indications
- HIV
- Pregnancy and Prophylaxis given ZDV
- Mechanism
- Inhibit Nucleotide Binding to Reverse Transcriptase
- Chain Termination
- Require Phosphorylation
1 min
NRTI Toxicity
- Bone Marrow Suppression
- Reverse with G-CSF and Erythropoietin
- Rash
- Neuropathy
- Anemia
- Pancreatitis
- Lactic Acidosis
1 min
NNRTIs (Non-nucleoside Reverse Transcriptase Inhibitors)
- Indications
- HIV
- Mechanism
- Do Not Require Intracellular Metabolism
- Inhibits Reverse Transcriptase
- Side Effects
- Rash
- Hepatotoxicity
- Vivid Dreams and CNS Symptoms
- Contraindication
- Pregnancy
2 mins
Protease Inhibitors
- End in "-navir"
- Indications
- HIV/AIDS
- Hepatitis C
- Mechanism
- Inhibit Protease
- Unable to Cleave Proteins
- Inhibits Maturation of New Virus
- Side Effects
- GI Distress
- Nephropathy
- Lipodystrophy
- Hyperglycemia
3 mins
Fusion Inhibitors
- Indications
- HIV
- Drugs
- Maraviroc
- Binds CCR-5 on T Cells
- Blocks Interaction with gp120
- Enfuvirtide
- Binds gp41
- Inhibits Viral Entry
- Side Effects
- Skin Reactions at Injection Sites (Enfuvirtide)
2 mins
Integrase Inhibitors
- -gravir Suffix
- Indications
- HIV
- Mechanism
- Blocks Insertion of Viral Genome
- Inhibit Actions of Integrase
- Side Effects
- Hypercholesterolemia
- Increased LFT's
- Insomnia
- Increased Creatine Kinase (CK)
1 min
