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HODI - week 1 - colon
Ulcerative Colitis Characteristics
Autoimmune
Mucosal and Submucosal Only
Rectal Involvement
Stepwise Lesions
Friable Pseudopolyp
Crypt Abscess
Loss of Haustra
Lead Pipe Appearance
Bloody Diarrhea
2 mins
Ulcerative Colitis Associations
Associations
Toxic Megacolon
Colorectal Carcinoma
Anterior Uveitis
Pyoderma Gangrenosum
Ankylosing Spondylitis
Primary Sclerosing Cholangitis
P-ANCA
1 min
Crohn's Disease Assessment
Diarrhea
5-6 per day
Cramping Abdominal Pain
Fever
Weight Loss
Malabsorption
Anemia
Complications
Obstruction
Fistulas
2 mins
Crohn's Disease Characteristics
Terminal Ileum and Colon
Rectal Sparing
Transmural Inflammation
Granulomas
Skip Lesions
Cobblestone Mucosa
Fissures
Fistulas
Perianal Disease
Creeping Fat
Lymphoid Aggregates
String Sign on Barium Swallow
2 mins
Crohn's Symptoms and Associations
Diarrhea
Malabsorption
Bile-Wasting
Pigment Gallstones
Oxalate Kidney Stones
Ankylosing Spondylitis
Erythema Nodosum
Uveitis
Migratory Polyarthritis
2 mins
Colorectal Cancer Assessment
3rd Most Common Cancer
Assessment
Change in Bowel Habits
Bowel Obstruction
Rectal Bleeding
Anemia
Weight Loss
Ascites
Considerations
Colonoscopy
FOBT and FIT
2 mins
Peutz-Jeghers Syndrome
Mechanism and Characteristics
Symptomatic Age: 10-30 Years
LKB1/STK11 Gene Mutation
Autosomal Dominant
Signs and Symptoms
Benign GI Hamartomatous Polyps
Mucocutaneous Hyperpigmentation
Positive Family History
Increased Risk of Colorectal Carcinoma
1 min
Clostridioides difficile (Clostridium difficile)
Characteristics
Gram-Positive
Bacillus
Anaerobe
Clindamycin and Ampicillin
Toxin A Enterotoxin
Damages Brush Border of Gut
Toxin B Cytotoxin
Damages Cytoskeletal Structure
Signs and Symptoms
Diarrhea
Pseudomembranous Colitis
Toxic Megacolon
Diagnosis
Detect Toxins in Stool
Treatment
Metronidazole
Vancomycin
3 mins
Shigella
Characteristics
Gram-Negative
Bacilli
Non Lactose Fermenting
White on Macconkey Agar
Oxidase Negative
Non H2S Producing
Day Care Centers
High Virulence
Replicates Intracellularly
Actin Rocket
Signs and Symptoms
Bloody Diarrhea
Shiga Toxin
Inhibits 60S Ribosome
Hemolytic Uremic Syndrome (HUS)
Hemolytic Anemia
Thrombocytopenia
Kidney Failure
3 mins
Bacillus Cereus Characteristics
Gram-Positive
Bacilli
Endospore Forming
B Hemolytic
Toxins and Enterotoxins
Reheated Rice
1 min
Bacillus Cereus Disease
Signs and Symptoms
Emetic Form
Short Incubation (1-6 Hours)
Nausea and Vomiting
Diarrheal Form
Long Incubation (8-16 Hours)
Diarrhea and GI Pain
2 mins
Clostridium botulinum
Characteristics
Bacillus
Gram-positive
Anaerobe
Spore-forming
Heat Labile Toxin
Inhibits Acetylcholine (Ach) Release at Neuromuscular Junction (NMJ)
Canned Food in Adults
Spores in Honey
Signs and Symptoms
Descending Flaccid Paralysis
Diplopia
Ptosis
Floppy Baby
Constipation
2 mins
Clostridium perfringens
Characteristics
Gram-Positive
Bacillus
Anaerobe
Spore-Forming
Alpha Toxin Lecithinase
Phospholipase
Heat Labile Enterotoxin
Signs and Symptoms
Myonecrosis
Gas Gangrene
Food Poisoning and Diarrhea
Treatment
Hyperbaric O2 Chamber
2 mins
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