Rosa Shared "Blood and Host Defense" - 87 Picmonics
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Blood and Host Defense
Hypersensitivity Type I
- Previous Antigen Exposure
- Immediate Reaction
- IgE Cross-linking
- Presensitized Mast Cells
- Histamine Release
- Vasodilation
- Anaphylaxis
- Allergies
- Treatment
- Epinephrine
1 min
Hypersensitivity Type II
- Cytotoxic
- IgM or IgG antibody-mediated
- Membrane Attack Complex (MAC)
- Mechanism
- Opsonization
- Complement Activation
- NK Cells
- Testing
- Direct Coombs test
- Indirect Coombs Test
1 min
Hypersensitivity Type III
- Immune Complex
- Antigen-antibody (IgG) complex activates complement
- Neutrophils release lysozomal enzymes
- Examples
- Arthus Reaction
- Serum Sickness
- Systemic Lupus Erythematosus (SLE)
1 min
Hypersensitivity Type IV
- Delayed-Type Hypersensitivity
- T Cell Mediated
- Antibody Independant
- Macrophages Activated
- Examples
- Transplant Rejection
- PPD Skin Test
- Contact Dermatitis
1 min
Human Immunodeficiency Virus (HIV) Interventions
- Interventions
- Adequate Nutrition
- Small Frequent Meals
- IV Hydration
- Emotional Support
- HIV Medications
- HAART
- Considerations
- Transmission Education
- Strict Asepsis for Invasive Procedures
- Treat Opportunistic Infections
2 mins
Human Immunodeficiency Virus (HIV) Diagnosis
- HIV-1/2 Antigen/Antibody Immunoassay
- HIV-1/2 Antibody Differentiation Immunoassay
- Nucleic Acid Testing (NAT)
- Viral Load
- Polymerase Chain Reaction (PCR) in Neonates
3 mins
Herpes Simplex Virus (HSV)
- Characteristics
- Enveloped
- Double Stranded DNA
- Linear
- Signs and Symptoms
- Type 1 HSV
- Gingivostomatitis
- Keratoconjunctivitis
- Encephalitis of Temporal Lobes
- Latent in Trigeminal Ganglia
- Type 2 HSV
- Genital Vesicles
- Neonatal Herpes
- TORCHES
- Latent in Sacral Ganglia
- Diagnosis
- Tzanck Test
- Multinucleated Giant Cells
- Cowdry A Inclusions
- Treatment
- Acyclovir
2 mins
Acyclovir (Zovirax)
- Mechanism
- Guanosine Analog
- Inhibits Viral Replication
- Thymidine Kinase Activation
- Indications
- Herpes Simplex Virus (HSV)
- Varicella Zoster Virus (VZV)
- Side Effects (Oral)
- Headache
- GI Distress
- Side Effects (IV)
- CNS Toxicity
- Nephrotoxicity (Crystalline Nephropathy)
- Considerations
- Prevents Recurrent Episodes
- Slow IV Infusion
2 mins
Human Immunodeficiency Virus (HIV) Assessment
- Assessment
- RNA Retrovirus
- CD4+ Helper T Cells
- Primary Infection
- Flu-like Symptoms
- Lymphadenopathy
- Symptomatic Stage
- Fatigue
- Diarrhea
- Unexplained Weight Loss
- White Spots on Tongue
- Persistent Fever
- Night Sweats
2 mins
Human Immunodeficiency Virus (HIV) Stages
- Primary Infection
- Within 3 Weeks
- Flu-like Symptoms
- Asymptomatic Stage
- Years
- Symptomatic Stage
- CD4+ < 500
- AIDS
- Opportunistic Infections
- CD4+ < 200
2 mins
HIV CD4+ 500
- Signs and Symptoms
- Candida albicans (Oral Thrush)
- Kaposi's Sarcoma (HHV-8)
- Human Papillomavirus (HPV)
- Epstein-Barr Virus (Oral Hairy Leukoplakia)
3 mins
HIV CD4+ 200
- Signs and Symptoms
- Herpes Simplex Virus (HSV)
- JC Virus
- Progressive Multifocal Leukoencephalopathy (PML)
- Pneumocystis Pneumonia
- (HIV) Dementia
- Histoplasmosis
3 mins
HIV CD4+ 100
- Signs and Symptoms
- Aspergillus fumigatus
- Cryptococcus neoformans
- Candida albicans (Esophagitis)
- Mycobacterium avium complex (MAC)
- Cytomegalovirus (CMV)
- Epstein-Barr virus (EBV) B-cell lymphoma
- Toxoplasma gondii
- Cryptosporidium
- Bartonella henselae
5 mins
NRTIs for HIV (Drug Names)
- Nucleoside Analog
- DEALSZ
- Didanosine (DDI)
- Emtricitabine (FTC)
- Abacavir (ABC)
- Lamivudine (3TC)
- Stavudine (d4T)
- Zidovudine (ZDV)
- Nucleotide Analog
- Tenofovir (TDF)
2 mins
HAART
- HIV
- Begin at Diagnosis
- 3 Drugs
- 2 NRTIs (Nucleoside Reverse Transcriptase Inhibitors)
- And one of the following:
- NNRTI (Non-Nucleoside Reverse Transcriptase Inhibitor)
- or Protease Inhibitor
- or Integrase Inhibitor
1 min
NRTIs (Nucleoside Reverse Transcriptase Inhibitors)
- Indications
- HIV
- Pregnancy and Prophylaxis given ZDV
- Mechanism
- Inhibit Nucleotide Binding to Reverse Transcriptase
- Chain Termination
- Require Phosphorylation
1 min
Protease Inhibitors
- End in "-navir"
- Indications
- HIV/AIDS
- Hepatitis C
- Mechanism
- Inhibit Protease
- Unable to Cleave Proteins
- Inhibits Maturation of New Virus
- Side Effects
- GI Distress
- Nephropathy
- Lipodystrophy
- Hyperglycemia
3 mins
Integrase Inhibitors
- -gravir Suffix
- Indications
- HIV
- Mechanism
- Blocks Insertion of Viral Genome
- Inhibit Actions of Integrase
- Side Effects
- Hypercholesterolemia
- Increased LFT's
- Insomnia
- Increased Creatine Kinase (CK)
1 min
Severe Combined Immunodeficiency (SCID)
- Both B and T Cell Deficiency
- Recurrent Viral, Bacterial, Fungal, Protozoal Infections
- Defective Interleukin (IL) 2 Receptor
- X-Linked
- Adenosine Deaminase Deficiency
- Failure to Synthesize MHC II Antigens
- Treat with Bone Marrow Transplant
2 mins
Cell-mediated Adaptive Immune Response
- Characteristics
- Macrophages and Dendritic Cells Present Antigens
- T Cell Develops Antigen Specificity
- Regulatory T Cells Suppress Response
- Memory T Cells Cause Faster Secondary Response
- Cytotoxic T Cells Lyse Infected Cells
- Infected Cells Present Antigen On Surface
2 mins
