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Z Reproduction
Repro Genes
Sonic Hedgehog
Made at base of limbs
Mutations lead to holoprosencephaly = field defect
Anterior Posterior Axis and CNS development
Homeobox (HOX)
blueprint for skeletal morphology
mutations lead to synpolydactyly (retinoid acid)
Codes for transcription factors
Segmental organization in craniocaudal axis
WNT-7
Dorsal / Ventral axis development
Made at the apical ectodermal ridge
Neural Crest Derivatives
CA MOTEL ASS
Craniofacial Structures (skull)
Arachnoid and Pia Mater
Melanocytes
Odontoblasts
Tracheal Cartilage
Enterochromaffin (Adrenal Medulla)
Laryngeal Cartilage
All Ganglia
Schwann Cells
Spiral Septum (Aorticopulmonary Septum)
2 mins
Surface Ectoderm Derivatives
Rathke's pouch
Anterior Pituitary
Lens and cornea
Inner Ear
Epidermis
Salivary glands
Sweat glands
Mammary glands
Parotid gland
Enamel of teeth
Distal anal canal
Mesoderm derivitives
Muscle
Bone
Bone marrow, blood, blood cells, blood vessels, heart
Adrenal cortex
Gonads
Dermis
Lymphatics
Upper vagina
Kidneys
Microglia
Spleen
Endoderm derivitives
GI tract
Liver
Gallblader
Pancreas
Lungs
Thymus
Thyroid follicular cells
Lower vagina
Bladder epithelium
Aortic Arch Derivatives
1st Arch
Maxillary Artery (branch of external carotid)
2nd Arch
Stapedial Artery and Hyoid Artery
3rd Arch
Common Carotid and Internal Carotid Arteries
4th Arch
Aortic Arch (left) and Subclavian Artery (right)
6th Arch
Pulmonary Arteries and Ductus Arteriosus
Pharyngeal Arch Derivatives: 1st Arch
Cartilage
Meckel's Cartilage
Mandible
Malleus
Incus
Sphenomandibular Ligament
Muscles
Muscles of Mastication
Tensor Tympani
Tensor Veli Palatini
Anterior Belly of the Digastric
Mylohyoid
Nerves
CN V2
CN V3
Conditions
Treacher Collins Syndrome
3 mins
Pharyngeal Arch Derivatives: 2nd Arch
Cartilage
Reichert's Cartilage
Stapes
Styloid Process
Lesser Horn of Hyoid
Stylohyoid Ligament
Muscles
Muscles of Facial Expression
Stapedius
Stylohyoid
Platysma
Posterior Belly of Digastric
Nerves
CN VII
Conditions
Congenital Pharyngocutaneous Fistula
2 mins
Pharyngeal Arch Derivatives: 3rd Arch
Cartilage
Greater Horn of Hyoid
Muscles
Stylopharyngeus
Nerves
CN IX (Glossopharyngeal)
Arteries
Common Carotid
Internal Carotid
1 min
Pharyngeal Arch Derivatives: 4-6 Arches
Cartilage
Thyroid
Cricoid
Arytenoids
Corniculate
Cuneiform
Muscles
4th: Cricothyroid
4th: Pharyngeal Constrictors
6th: Intrinsic Muscles of Larynx
Nerves
4th: CN X (Vagus Nerve)
Superior Laryngeal Branch
6th: CN X (Vagus Nerve)
Recurrent Laryngeal Branch
2 mins
Branchial Pouches: 1st Pouch
Endoderm Lines the Auditory Tube
Middle Ear Cavity
Eustachian Tube
Mastoid Air Cells
1 min
Branchial Pouches: 2nd Pouch
Palatine Tonsils
38 secs
Branchial Pouches: 3rd Pouch
Separates into Dorsal and Ventral Wings
Dorsal Wings
Inferior Parathyroid Glands
Ventral Wings
Thymus
1 min
Branchial Pouches: 4th Pouch
Separates into Dorsal and Ventral Wings
Dorsal Wings
Superior Parathyroid Glands
Ventral Wings
Parafollicular (C) Cells of Thyroid Gland
Formed by Endoderm
1 min
Mayer-Rokitansky-Kuster-Hauser Syndrome
AKA Mullerian Aplasia
Normal ovaries
Normal estrogen
Normal secondary sexual characteristics (breasts, pubic hair)
no uterus, no upper vagina
primary amenorrhea
Rudimentary lower vagina is possible
Low Testosterone levels
Congenital Penile Abnormalities
Hypospadias
Hypospadias
Failure of urethral folds to fuse
inguinal hernia
Undescended Testicles (Cryptorchidism)
Epispadias
Epispadias
Faulty positioning of genital tubercle
bladder exstrophy
APGAR Score
1 and 5 Minutes
Appearance
Pulse
Grimace
Activity and Muscle Tone
Respiration
Total Scores
Gentle Stimulation
Oxygen
2 mins
Ovulatory Hormones I - Follicular Phase
Characteristics
0-14 Days
GnRH Stimulates FSH and LH
Follicle Secretes Estrogen
Negative Feedback from Estrogen
Increased Estrogen Leads to Positive Feedback
FSH and LH Surge
LH Spike Leads to Ovulation
2 mins
Ovulatory Hormones II - Luteal Phase
Days 15-28
Corpus Luteum
Secretes Progesterone
Negative Feedback inhibits FSH and LH
No pregnancy forms Corpus Albicans
Stops Estrogen Secretion
Endometrial Sloughing - Menses
GnRH secretion produces new follicular phase
2 mins
Oogenesis
Characteristics
Primary Oocytes From Birth
Meiosis I Once a Month
Secondary Oocyte Plus Polar Body
Frozen in Metaphase II, in Meiosis II
Ovulation
Fertilization by Sperm
Meiosis II
Ovum
Zygote Forms
2 mins
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