Pencil Villain Shared "Step 1 - Top 20 High Yield Picmonics" - 20 Picmonics
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Step 1 - Top 20 High Yield Picmonics
P450 Inhibitors
Quinidine
Ciprofloxacin
Isoniazid
Grapefruit Juice
Acute Alcohol Use
Erythromycin (Macrolide)
Indinavir
Cimetidine
Sulfonamides
Ketoconazole
Amiodarone
2 mins
P450 Inducer
Griseofulvin
Phenytoin
Carbamazepine
Rifampin
Barbiturates
Chronic Alcohol Use
St. John's Wort
51 secs
Hurler Syndrome
Pathophysiology
Autosomal Recessive
Mucopolysaccharidoses
Alpha-L-Iduronidase Deficiency
Increased Heparan Sulfate
Increased Dermatan Sulfate
Signs and Symptoms
Hepatosplenomegaly
Developmental Delay
Gargoylism
Corneal Clouding
Airway Obstruction
2 mins
Hunter Syndrome
Pathophysiology
X-linked Recessive
Mucopolysaccharidoses
Iduronate Sulfatase Deficiency
Increased Dermatan Sulfate
Increased Heparan Sulfate
Signs and Symptoms
No Corneal Clouding
Aggressive Behavior
1 min
Tay-Sachs Disease
Pathophysiology
Autosomal Recessive
Hexosaminidase A Deficiency
Increased GM2 Ganglioside
More Common in Ashkenazi Jewish Population
Signs and Symptoms
Cherry Red Spot on Macula
Neurodegeneration
Developmental Delay
Diagnosis
Onion Skin Lysosomes
1 min
Fabry's Disease
Pathophysiology
X-linked Recessive
Alpha-galactosidase A Deficiency
Increased Ceramide trihexoside
Early Signs and Symptoms
Decreased Sweating (Hypohidrosis)
Angiokeratoma
Episodic Peripheral Neuropathy
Late Signs and Symptoms
Cardiovascular Disease
Renal Failure
1 min
Fragile X
Pathophysiology
Trinucleotide Repeat
CGG Repeats
FMR1 Gene
X-linked Dominant
Signs and Symptoms
Developmental Delay
Autism
Large Ears
Large Jaw
Long Face
Macroorchidism
2 mins
Marfan Syndrome
Mechanism
Fibrillin-1 Mutation
Symptoms
Autosomal Dominant
Tall
Arachnodactyly
Pectus Excavatum
Hypermobile Joints
Aortic Aneurysm And Dissection
Mitral Valve Prolapse (MVP)
Subluxation of Lens (Superior)
2 mins
Age 2 Months - Developmental Milestones
Gross Motor
Holds Head Up, But Unsteady
Moves Both Arms and Both Legs
Fine Motor
Opens Hands Briefly
Tracks Objects to the Midline
Language/Communication
Produces Sounds Aside from Crying
Reacts to Loud Noise
Social / Cognitive
Social Smile
Recognizes Parents
Soothed When Spoken to or Picked Up
2 mins
Age 4 Months - Developmental Milestones
Gross Motor
Keeps Head Steady Without Support
Pushes Up on Elbows While on Tummy
Fine Motor
Holds a Toy in Hands
Moves Hands Towards Mouth
Language/Communication
Cooing
Turns to Voice
Social / Cognitive
Chuckles
Enjoys Looking Around
Looks at Hands With Interest
Opens Mouth When Hungry
2 mins
Vitamin D Metabolism/Mechanism
Mechanism Of Action
Ergocalciferol (Vitamin D2)
Plant Sources
Cholecalciferol (Vitamin D3)
Sunlight Conversion in Skin
7-Dehydrocholesterol
Liver Hydroxylation
25-(OH) D (25-hydroxyvitamin D)
Storage Form
Kidney Hydroxylation
1,25-(OH)2 D (1,25-dihydroxyvitamin D)
Active Form Calcitriol
Absorbs Calcium and Phosphorus in Intestine
4 mins
Vitamin B6 (Pyridoxine) Deficiency
Deficiency From Isoniazid
Deficiency From Oral Contraceptives
Seizures
Hyperirritability
Peripheral Neuropathy
Sideroblastic Anemia
3 mins
Specificity
Characteristics
Rules In
Confirmatory Test
Formula
TN / (TN + FP)
1 min
Sensitivity
Characteristics
Rules Out
Screening Test
Formula
TP / (FN+TP)
2 mins
Acute Intermittent Porphyria (AIP)
Pathophysiology
Autosomal Dominant
Inhibited Porphobilinogen Deaminase
Increased Serum Porphobilinogen
Increased Serum Delta-ALA
Increased Urinary Porphyrin Precursors
Signs & Symptoms
Precipitated By P450 Inducers
Painful Abdomen
Polyneuropathy
Psychological Disturbances
Port Wine-Colored Urine
Treatment
Glucose and Hemin
Considerations
Avoid Triggers
3 mins
Fetal Circulation
Placenta
Umbilical Vein
Ductus Venosus
Right Atrium
Foramen Ovale
Left Atrium
Aorta
Right Ventricle
Ductus Arteriosus
Umbilical Arteries
2 mins
Acetylcholinesterase Inhibitor Antidote
Antidote
Atropine
Pralidoxime
1 min
Bipolar Disorder Assessment
Mechanism
Neurotransmitter Dysregulation and Genetic Factors
Mania Signs and Symptoms
Euphoric Mood
Nonstop Physical Activity
Flight of Ideas
Rapid Speech
Depression Signs and Symptoms
Mood Changes
Sad Affect
Psychomotor Retardation
Suicidal Thoughts
2 mins
Neurofibromatosis Type 1
Pathophysiology
Autosomal Dominant
Chromosome 17
Signs and Symptoms
Neurofibromas
Optic Glioma
Lisch Nodules
Hamartomas
Cafe Au Lait Spots
Scoliosis
Pheochromocytoma
4 mins
Anti-desmoglein Antibodies
Pemphigus Vulgaris
Flaccid Blisters
Skin and Oral Mucosa
Positive Nikolsky's Sign
59 secs
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