Ashton Shared "GI - Pharmacology" - 26 Picmonics
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GI - Pharmacology
Hepatitis B Virus Characteristics
- Hepadnavirus
- Enveloped
- Circular
- Partially Double-stranded DNA
- Has Reverse Transcriptase
- IV Drug Use
- Sex
- Maternal Fetal Routes
- 3 Month Incubation Period
2 mins
Hepatitis B Virus Disease
- Can turn chronic
- < 10% of adults become chronic carriers
- 90% of newborns become chronic carriers
- Cirrhosis
- Hepatocellular carcinoma
- Membranous Glomerulonephritis
- Polyarteritis nodosa
- Serum sickness like syndrome
2 mins
Hepatitis B (HBV) Assessment
- Transmission
- Bodily Fluids
- Blood Transmission
- People Who Use IV Drugs
- Incubation
- Variable 1-6 Months
- Assessment
- Fever
- Nausea and Vomiting
- Hepatomegaly
- Chronic Disease
- Cirrhosis
- Hepatocellular Carcinoma
- Considerations
- Vaccination
2 mins
NRTIs for HIV (Drug Names)
- Nucleoside Analog
- DEALSZ
- Didanosine (DDI)
- Emtricitabine (FTC)
- Abacavir (ABC)
- Lamivudine (3TC)
- Stavudine (d4T)
- Zidovudine (ZDV)
- Nucleotide Analog
- Tenofovir (TDF)
2 mins
NRTIs (Nucleoside Reverse Transcriptase Inhibitors)
- Indications
- HIV
- Pregnancy and Prophylaxis given ZDV
- Mechanism
- Inhibit Nucleotide Binding to Reverse Transcriptase
- Chain Termination
- Require Phosphorylation
1 min
NRTI Toxicity
- Bone Marrow Suppression
- Reverse with G-CSF and Erythropoietin
- Rash
- Neuropathy
- Anemia
- Pancreatitis
- Lactic Acidosis
1 min
Hepatitis C
- Characteristics
- Enveloped
- RNA Virus
- Flavivirus
- Icosahedral
- SS positive Linear
- Clinical Features
- Most Cases are Due to IV Drug Use
- Turns to Chronic Hepatitis in Over 70% of Cases
- Cirrhosis
- Hepatocellular Carcinoma
- Most Common Indication for Liver Transplantation
- Associated With Type I MPGN
- Porphyria Cutanea Tarda
2 mins
Hepatitis C (HCV) Assessment
- Transmission
- Blood Transmission
- High Risk Sex (rare)
- IV Drug Users
- Incubation
- 7 Weeks
- Chronic Disease
- Cirrhosis
- Considerations
- Barrier Protection
2 mins
HCV Treatment
- Simeprevir
- Simeprevir toxicities
- Pegylated IFN-a
- Ribavirin
- Sofosbuvir
- Sofosbuvir toxicities
- Ledipasvir
Ribavirin
- Mechanism
- Hypermutation in RNA Viruses
- Inhibits Inosine Monophosphate Dehydrogenase
- Indications
- Hepatitis C
- Viral Hemorrhagic Fevers
- Respiratory Syncytial Virus (RSV)
- Side Effects
- Hemolytic Anemia
- Teratogen
1 min
Peptic Ulcer Disease Assessment
- Mechanism/Cause
- Helicobacter Pylori
- NSAIDs
- Increased Stomach Acid
- Assessment
- Abdominal Pain
- Heartburn (Pyrosis)
- Melena
- Weight Changes
- GI Distress
- Considerations
- Most Commonly in Duodenum
- Duodenal: Pain Relieved by Eating
- Gastric: Pain Caused by Eating
2 mins
Peptic Ulcer Disease Interventions
- Combination Drug Therapy
- Two Antibiotics
- Proton Pump Inhibitor (PPI)
- Decrease Acid Secretion
- Avoid NSAIDs
- Diet and Lifestyle Changes
1 min
H2 Receptor Blocker
- "-tidine" Suffix
- Indications
- Gastroesophageal Reflux Disease (GERD)
- Peptic Ulcer
- Mechanism
- Block Histamine H2 Receptors
- Parietal Cells
52 secs
Cimetidine and Famotidine (H2 Receptor Blockers)
- -tidine Suffix
- Mechanism
- H2 Receptor Blocker
- Indications
- Suppress Gastric Acid Secretion
- Side Effects (All)
- Pneumonia
- Side Effects - Cimetidine
- Anti-androgen Effects
- CNS Changes
2 mins
H2 Receptor Blocker Side Effects
- Side Effects
- Decrease Creatinine Clearance
- Cimetidine
- Crosses Blood-Brain Barrier
- Anti-Androgen
- Inhibits Cytochrome P450
1 min
Proton Pump Inhibitors (PPIs)
- "-prazole" Suffix
- Indications
- Zollinger-Ellison Syndrome
- Gastritis
- Peptic Ulcer
- Gastroesophageal Reflux Disease (GERD)
- Mechanism
- Inhibit H+/K+/ATPase
- Side Effects
- Hip fracture
- Pneumonia
2 mins
Sucralfate (Carafate)
- Mechanism
- Creates Protective Barrier
- Indications
- GI Ulcers
- Side Effects
- Constipation
- Considerations
- Require Acidic Environment
- Give on Empty Stomach
- Oral Suspension Available
- May Decrease Absorption of Other Meds
2 mins
Dinoprostone and Misoprostol
- Mechanism
- Prostaglandins
- Indications
- Promote Cervical Ripening
- Prevent GI Ulcers
- Medical Abortion
- Side Effects
- Fetal Distress
- Hyperstimulation of Uterus
- Considerations
- Vaginal Insertion
- Give Before Induction of Labor
2 mins
Helicobacter Pylori
- Characteristics
- Gram-Negative
- Bacilli
- Curved
- Polar Flagellum
- Catalase-Positive
- Oxidase-Positive
- Disease
- Gastric and Duodenal Ulcers
- Ammonia
- Neutral Environment
- Gastric Adenocarcinoma
- MALT lymphoma
- Diagnosis
- Serology IgG antibody
- Stool Antigen
- Urease Positive Breath Test
- Biopsy
- Treatment
- 2 ABX and PPI
2 mins
Ondansetron
- Indications
- Postoperative Vomiting
- Chemotherapy-induced Nausea and Vomiting
- Mechanism
- 5-HT3 Serotonergic Antagonist
- Centrally-acting Antiemetic
- Side Effects
- Headache
- Constipation
- QT Prolongation
1 min
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