Sara Shared "Student Created: Polyposis Syndromes" - 4 Picmonics
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Student Created: Polyposis Syndromes
Gardner Syndrome
- Pathophysiology
- Familial Adenomatous Polyposis (FAP) with Extraintestinal Benign Growths
- Autosomal Dominant
- APC Gene Mutation
- Extraintestinal and Benign Manifestations
- Desmoid Tumors
- Nasal Angiofibromas
- Osteomas
- Congenital Hypertrophy of Retinal Pigment Epithelium (CHRPE)
- Dental Abnormalities
- Cutaneous Lesions
- Adrenal Adenomas
- Associated Malignancies
- Thyroid Cancer
- Duodenum/Periampullary Cancer
- Pancreatic Cancer
- Hepatoblastoma
Juvenile Polyposis Syndrome
- PATHOPHYSIOLOGY
- Autosomal Dominant
- Children < 5 Years Old
- manifestations
- Hamartomatous Polyps
- Found in the Stomach, Small Intestine and Colon
- Large Number Increases Risk of Colorectal Carcinoma
2 mins
Turcot Syndrome
- Pathophysiology
- Autosomal Dominant or Autosomal Recessive
- Colonic Polyposis and a Malignant Central Nervous System Tumor
- Associations
- Increased Risk of Colorectal Cancer
- Increased Risk of Brain Cancer
- Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer)
- Glioblastoma Multiforme
- Familial Adenomatous Polyposis (FAP)
- Medulloblastoma
3 mins
Familial Adenomatous Polyposis (FAP)
- Pathophysiology
- Autosomal Dominant
- Mutation on Chromosome 5
- APC Tumor Suppressor Gene Mutation
- Overexpression of β-catenin
- Two-Hit Hypothesis
- manifestations
- Postpubertal Appearance of Thousands of Polyps
- Always Involves Rectum
- Pancolonic
- Associations
- Hepatoblastoma
- Most Patients Develop Colorectal Carcinoma (CRC) by 40 years of age
- Interventions
- Prophylactic Colectomy
3 mins
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