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Fundamentals of Pharmacology
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Toxicities & Antidotes

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Fundamentals of Pharmacology | General Allied Health School Study Aid

Toxicities & Antidotes
31 Picmonics to Learn | 47 mins
Benzodiazepine Intoxication Assessment
Drowsiness
Confusion
Respiratory Depression
Hypotension
Coma
Treatment
Flumazenil (Romazicon)
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2 mins
Benzodiazepine Antidote
Antidote
Flumazenil
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40 secs
Warfarin Antidotes
Antidotes
Vitamin K
Fresh Frozen Plasma
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59 secs
Alteplase
Mechanism
Tissue Plasminogen Activator
Indications
Thrombosis
Side Effects
Bleeding
Contraindications
Intracranial Hemorrhage
Internal Hemorrhaging
Considerations
Minimize Bleeding
Monitor for Shock
Antidote
Aminocaproic Acid
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2 mins
Acetylcholinesterase Inhibitor Poisoning
DUMBBELSS
Diarrhea
Urination
Miosis
Bronchospasm
Bradycardia
Emesis
Lacrimation
Salivation
Sweating
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2 mins
Acetylcholinesterase Inhibitor Antidote
Antidote
Atropine
Pralidoxime
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1 min
Aspirin Poisoning (Salicylism) Assessment
Early Symptoms
Nausea and Vomiting
Tinnitus
Confusion
Hyperventilation
Respiratory Alkalosis
Late Symptoms
Metabolic Acidosis
Coma
Hyperthermia
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1 min
Atropine
Mechanism of Action
Muscarinic Antagonist
Indications
Bradycardia
Increased Exocrine Secretions
Smooth Muscle Spasms
Side Effects
Tachycardia
Dry Mouth
Urinary Retention
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2 mins
Antimuscarinic Antidote
Antidote
Physostigmine Salicylate
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44 secs
Amphetamines Intoxication Assessment
Euphoria
Insomnia
Mydriasis
Diaphoresis
Hypertension
Tachycardia
Paranoia
Anxiety
Anorexia
Seizures
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2 mins
Amphetamine Antidote
Antidote
Ammonium Chloride (NH4Cl)
Acidify Urine
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34 secs
Beta Blocker Antidote
Antidote
Glucagon
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29 secs
Arsenic, Gold and Copper Antidotes
Toxic Metals
Arsenic
Gold
Copper
Antidotes
Penicillamine
Dimercaprol (BAL)
Succimer
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2 mins
Iron Antidote
Antidote
DeFEroxamine
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23 secs
Opioid Antidote
Antidote
Naloxone
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29 secs
Tricyclic Antidepressant (TCA) Antidote
Antidote
Sodium Bicarbonate (NaHCO3)
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27 secs
Lead Antidotes
Antidotes
Dimercaprol
CaEDTA
Succimer
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39 secs
Acute Digoxin Toxicity
Clinical Symptoms
Hyperkalemia
Cholinergic (Nausea, Vomiting, Diarrhea)
Blurry Yellow Green Vision with Halo of Light
Arrhythmia
Bradycardia
EKG Changes
Prolonged PR interval
Decreased QT
Scooping on EKG
T Wave Inversion
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2 mins
Digoxin Toxicity Treatment
Activated Charcoal
Slowly Normalize K+
Digibind (Anti-Digoxin Fab)
Magnesium Sulfate
Lidocaine
Cardiac Pacing
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2 mins
Activated Charcoal (Actidose)
Mechanism
Binds to Toxins
Indications
Ingested Poison
Side Effects
Black Stool
GI Distress
Considerations
Give As Soon As Possible
Via Mouth or NG Tube
Gastric Lavage
Do Not Administer with Antidotes
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2 mins
Substance Use Disorder Assessment (Formerly Substance Abuse Assessment)
Changes in Mood
Poor Hygiene
Odd Sleep Patterns
Frequent Injuries
Relationship or Job Difficulty
Poor Performance
Anorexia OR Weight Loss
Social Isolation
Financial Problems
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2 mins
Marijuana Intoxication Assessment
Euphoria
Slowed Reaction Time
Conjunctival Injection
Increased Appetite
Anxiety
Social Withdrawal
Paranoid Delusions
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2 mins
Alcohol Use Disorder Assessment (Formerly Alcohol Abuse Assessment)
Intoxication
CNS Depression
Withdrawal
Wernicke-Korsakoff Syndrome
Medical Complications
GI Distress
Cardiomyopathy
Pancreatitis
Cirrhosis
Immunosuppression
Sexual Dysfunction
Considerations
Screening (Assessments)
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3 mins
Alcohol Use Disorder Interventions (Formerly Alcohol Abuse Interventions)
Withdrawal
Reduce Environmental Stimuli
Antianxiety Medications
Vitamin Supplements
Seizure Precautions
Suicide Precautions
Fever
Considerations
Identify Support Systems
Group Therapy
Disulfiram
Naltrexone
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2 mins
Cocaine Intoxication Assessment
Euphoria
Delusions
Mydriasis
Hallucinations
Agitation
Hypertension
Arrhythmias
Hyperthermia
Seizures
Nasal Septum Perforation
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2 mins
Phencyclidine (PCP) Intoxication Assessment
Violent Behavior
Motor Issues
Nystagmus
Increased Pain Tolerance
Tachycardia
Delirium
Seizures
Psychosis
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2 mins
LSD Intoxication Assessment
Psychosis
Perceptual Distortion
Visual Hallucinations
Paranoia
Depersonalization
Anxiety
Tachycardia
Flashbacks
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2 mins
Opioid Use Disorder and Withdrawal Assessment (Formerly Opioid Abuse and Withdrawal Assessment)
Abuse Assessment
Euphoria
Miosis
CNS Depression
Abuse Withdrawal
Yawning
Gooseflesh
Sweating
Rhinorrhea
Kicking Movements
Consideration
Naloxone
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1 min
Naloxone (Narcan)
Mechanism
Competitive Opioid Receptor Antagonist
Indications
Opioid Induced CNS Depression
Side Effects
Severe Nausea and Vomiting
Excitable State
Opioid Withdrawal Symptoms
Considerations
Repeated Dosing Often Required
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1 min
MDMA (Ecstasy) Toxicity: Management
Airway Management
Management of Hypertension
Benzodiazapines
Nitroprusside
Activated Charcoal if Within One Hour of Ingestion
Ice Bath if Hyperthermic
Cyproheptadine if Serotonin Syndrome
Fluid Restriction for Hyponatremia
Hypertonic Saline if Hyponatremia + Altered Mental Status
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4 mins
Cyanide Poisoning Diagnosis and Treatment
Lab Findings
Lactic Acidosis
Elevated Venous PO2
Check Carboxyhemoglobin
Management
Sodium Nitrate PLUS Sodium Thiosulfate
Methemoglobinemia
OR Hydroxocobalamin (First Line)
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4 mins

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