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General Allied Health
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First Aid
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First Aid for the USMLE Step 1 (2022)
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First Aid for the USMLE Step 1 (2022) | General Allied Health School Study Aid

Page 327 -
4 Picmonics to Learn | 7 mins
Fibrates
Indications
Hyperlipidemia
Mechanism of Action
Upregulate LPL
Decreases Triglycerides
Slight Increase in HDL
Slight Decrease in LDL
Side Effect
Hepatotoxicity
Cholesterol Gallstones
picmonic thumbnail
1 min
Niacin Therapy (Vitamin B3)
Mechanism
Inhibits Lipolysis in Adipose Tissue
Reduces Hepatic VLDL Secretion
Indications
Decrease Triglycerides
Decrease LDL
Increase HDL
Side Effects
Flushing
Decreased by Aspirin
Hyperglycemia
Hyperuricemia
picmonic thumbnail
2 mins
Ranolazine
Mechanism
Inhibits Late Sodium Current
No Effect on Heart Rate or Blood Pressure
Prevents Calcium Overload
Indication
Refractory Angina
Side Effects
Dizziness
Headache
Nausea
Constipation
QT Interval Prolongation
picmonic thumbnail
1 min
PCSK9-Inhibitors
AVAILABLE DRUGS
Evolocumab
Alirocumab
MECHANISM OF ACTION
Monoclonal Antibodies
Bind the PCSK9 Enzyme
Decreased Degradation of LDL-receptors
Increased LDL Receptors on Hepatocytes
Reduction of LDL in Plasma
INDICATION
Second-line Therapy for Hypercholesterolemia
ADMINISTRATION
Subcutaneous Injection
SIDE EFFECTS
Skin Reaction at the Injection Site
Myalgia
Neurocognitive Impairment
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2 mins

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