Penicillin
- Weakens Cell Wall
- Gram-Positive Infections
- Prophylaxis
- Pain at IM Injection Site
- Allergic Reaction
- Skin Tests
- Allergy ID
- Medication Education
Ampicillin and Amoxicillin
- Aminopenicillin
- Broad Spectrum Penicillin
- Gram-Positive and Some Gram-Negative Infections
- Rash
- Diarrhea
- No Effect Against Staph Aureus
- Often combined with Beta Lactamase Inhibitor
- Allergic Reaction
Aztreonam (Azactam)
- Monobactam Antibiotic
- Bactericidal
- Gram-Negative Infections
- No Activity on Gram-Positives or Anaerobes
- Blood Dyscrasias
- Pain at Injection Site
- Safe for Penicillin Allergy
- Synergistic with Aminoglycosides
- Nebulizer Form Available
Cephalosporins
- Starts with "Cef-"
- Bactericidal
- Gram-Positive and Gram-Negative Infections
- Allergic Reactions
- Thrombophlebitis
- Bleeding
- Renal Impairment
- Avoid IV Calcium with Ceftriaxone
- No Alcohol
Imipenem and Meropenem (Carbapenems)
- Carbapenems
- Broad-spectrum Antibiotic
- Bactericidal
- Gram Positive and Gram Negative Infections
- GI Distress
- Suprainfections
- Seizures
- Penicillin Allergy
- IV or IM Route
- Imipenem Combined with Cilastatin
Macrolides
- Bacteriostatic
- Bind to 23S rRNA of 50S Subunit
- Inhibit Protein Synthesis by Blocking Translocation
- Erythromycin
- Azithromycin
- Clarithromycin
- Gram-Positive Cocci
- Atypical Pneumonia
- Chlamydia
- Resistance by Methylation of 23S rRNA Binding
Macrolides Side Effects
- Diarrhea
- Prolonged QT Interval
- P450 Inhibitor
- Cholestatic Hepatitis
- Skin Rash
- Eosinophilia
Aminoglycoside Overview
- End in "-mycin"
- Gentamicin
- Neomycin
- Amikacin
- Tobramycin
- Streptomycin
- Bactericidal
- Severe Gram Negative Infections
- Bowel Surgery Prep
Aminoglycoside Side Effects
- Ototoxicity
- Nephrotoxicity
- Respiratory Paralysis
- Pregnancy
- Peak and Trough
- Never Mix with Penicillin in Same IV
Neomycin Sulfate
- Aminoglycoside Antibiotic
- Topical Infection
- Intestinal Surgery Prophylaxis
- Ototoxicity
- Nephrotoxicity
- Rash
- Blood Dyscrasias
- GI Superinfection
Chloramphenicol (Chloromycetin)
- Bacteriostatic
- Gram Positive or Gram Negative Infections
- Bone Marrow Suppression
- Aplastic Crisis
- Gray Syndrome
- Toxicity Limits Use
- Monitor Blood Counts
Tetracyclines Overview
- End in "-cycline"
- Bacteriostatic
- Infectious Diseases
- Acne
- Periodontal Disease
- Avoid Milk, Antacids, Iron
- Sunlight Protection
Tetracyclines Side Effects
- Superinfection
- Clostridioides difficile
- Discoloration of Teeth
- Bone Deformities
- Photosensitivity
- Children Under 8
- Pregnancy
Tetracycline Toxicities
- Inhibition of Bone Growth in Children
- Teratogen
- Discoloration of Teeth
- Photosensitivity
- GI Distress
Tigecycline (Tygacil)
- Glycylcycline Antibiotic
- Binds 30S Subunit
- Inhibits Protein Synthesis
- Severe Infections
- Broad Spectrum Coverage
- Anaerobic & Multidrug-Resistant Organisms
- Deep Tissue Penetration
- GI Distress
- Severe Nausea and Vomiting
- 2nd Line Agent
Fluoroquinolones
- End in "-floxacin"
- Bactericidal
- Variety of Infections
- GI Distress
- Photosensitivity
- Achilles Tendon Rupture
- Pregnancy
- Children
- Myasthenia Gravis
- Avoid Milk Products or Antacids
- Slow IV Infusion
Fluoroquinolones Toxicities
- Diarrhea
- Skin Rash
- Headache
- Tendon Rupture in Adults
- Myalgias in Kids
- Damage to Cartilage
- Teratogen
- QT Prolongation
Vancomycin
- Inhibits Bacterial Cell Wall Synthesis
- Serious Gram-Positive Infections
- Nephrotoxicity
- Ototoxicity
- Red Man Syndrome
- Thrombophlebitis
- Culture Samples First
- Infuse IV Over 60 Minutes
- Take Around the Clock
Vancomycin Side Effects & Toxicity
- Thrombophlebitis
- Nephrotoxicity
- Ototoxicity
- Diffuse Flushing Called Red Man Syndrome
- Prevent with Antihistamine
- Prevent with Slow Infusion
Linezolid (Zyvox)
- Oxazolidinone Antibiotic
- Binds 23S rRNA of 50S Subunit
- Inhibits Protein Synthesis
- Gram-Positive Organisms
- MRSA
- VRE (Vancomycin Resistant Enterococci)
- Bone Marrow Suppression
- Decreased Platelet Count
- Peripheral Neuropathy
- Lactic Acidosis
- Serotonin Syndrome
- Avoid Tyramine Containing Foods
Clindamycin
- Bacteriostatic
- Binds 50S Ribosomal Subunit
- Gram-Positive Infections
- Anaerobic Infections
- Rash
- Pseudomembranous Colitis
- C. Difficile (Associated Diarrhea)
- Arrhythmias
- Blood Dyscrasias
- Monitor for Diarrhea
Sulfonamides
- Bacteriostatic
- Urinary Tract Infection
- Crystalluria
- Photosensitivity
- Hemolytic Anemia
- Kernicterus
- Rash
- Sulfa Allergy
- Encourage Fluids
Sulfonamides Side Effects
- Hypersensitivity
- Nephrotoxicity
- Photosensitivity
- Kernicterus in Infants
- Displaces Warfarin from Albumin
- Hemolysis with G6PD Deficiency
Silver Sulfadiazine (Silvadene) and Mafenide Acetate (Sulfamylon)
- Topical Antimicrobial
- Burns
- Open Wound Care
- Mafenide
- Pain
- Acidosis
- Administer Analgesic Prior to Wound Care
Sulfa Drug Allergies
- Sulfasalazine
- Sulfonylureas
- Thiazide Diuretics
- Acetazolamide
- Furosemide Diuretic
- Celecoxib
- Probenecid
Metronidazole
- Bactericidal
- Forms Free Radical Toxic Metabolites
- Damages DNA
- Giardia lamblia
- Entamoeba Histolytica
- Trichomonas
- Gardnerella
- Anaerobes
- Metallic taste
- Disulfiram like Reaction with Alcohol