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Medicine (MD/DO)
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USMLE Step 1
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Pharmacology
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Gynecologic Oncology Agents

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Pharmacology | Medicine (MD/DO) School Study Aid

Gynecologic Oncology Agents
5 Picmonics to Learn | 7 mins
Trastuzumab
Indications
HER-2+ Breast Cancer
Stomach Cancer
Mechanism
Monoclonal Antibody Against HER-2
Inhibition of Cellular Signaling
Cytotoxicity
Side effects
Cardiotoxicity
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1 min
Tamoxifen
Mechanism of Action
Selective Estrogen Receptor Modulator (SERM)
Antagonist on Breast Tissue
Indications
ER-positive Breast Cancer
Side Effects
Decreased Risk of Osteoporosis
Increased Risk of Endometrial Cancer
Increased Risk of Venous Thromboembolism (VTE)
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1 min
Aromatase Inhibitors
Indications
Estrogen Receptor-positive (ER+) Breast Tumors
Systemic Metastases
Drugs
Reversible, non-steroid
Letrozole
Anastrozole
Irreversible, steroid
Exemestane
Side Effects
Osteoporosis
Arthritis
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1 min
Paclitaxel (Taxanes)
Mechanism of Action
Taxane
Stabilizes Microtubules
Indications
Breast Cancer
Ovarian Cancer
Non-Small Cell Lung Cancer
Kaposi Sarcoma (HHV-8)
Side Effects
Mucositis
Myelosuppression
Peripheral Neuropathy
Hypersensitivity
Alopecia
Considerations
Diphenhydramine (Benadryl)
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2 mins
Raloxifene
Mechanism of Action
Selective Estrogen Receptor Modulator (SERM)
Agonist in Bone
Antagonist in Breast and Uterus
Indications
Osteoporosis
Breast Cancer Prophylaxis
Uterine Fibroids
Side Effects
Hot Flashes
Thromboembolism
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2 mins

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