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Endocrinology | Medicine (MD/DO) School Study Aid
Insulin
- Rapid Acting
- Insulin Lispro (Humalog)
- Insulin Aspart (Novolog)
- Insulin Glulisine (Apidra)
- Short Acting
- Regular Insulin (Humulin R)
- Intermediate Acting
- Isophane NPH (Humulin N)
- Long Acting
- Detemir (Levemir)
- Glargine (Lantus)
2 mins
Hyperglycemia
- Mechanism
- Insulin Resistance
- Too Little Insulin/Medication
- Infection/Illness
- Corticosteroids
- Assessment
- Elevated Blood Glucose
- Polyphagia
- Polydipsia
- Polyuria
- Hypotension
- Fatigue/Drowsiness
1 min
Corrected Na+ for Hyperglycemia
- Equation
- [(Glucose-100) * 0.016 ] + Na+
- Steps
- Glucose-100
- Multiply * 0.016
- Add Na+
1 min
Hypoglycemia Assessment
- Mechanism
- Too much insulin
- Decreased glucose
- Assessment
- < 70 mg/dL
- Change in LOC
- Lethargic
- Confusion and Irritability
- Tremors
- Diaphoresis
- Tachycardia
- Vision Changes
- Weakness
- Seizures
2 mins
Glucagon (GlucaGen)
- Mechanism
- Increases Glucose
- Indications
- Hypoglycemic Emergency
- Side Effects
- Nausea and Vomiting
- Considerations
- Reconstitute Powder
- Consume Oral Carbohydrates
- 50% Dextrose IV (If No Effect)
2 mins
Insulin Synthesis
- Synthesis
- Preproinsulin
- Rough Endoplasmic Reticulum
- Proinsulin
- Golgi Body
- Beta Cells Release Insulin
- Beta Cells Release C-peptide
- Clinical Relevance
- Insulinoma
- Sulfonylureas
- Surreptitious Insulin Use
2 mins
Insulin Regulation
- Master Regulator
- Glucose
- Incretins Released with Oral Glucose
- GLP-1
- GIP
- Positive Regulators
- Beta-2 Receptor Stimulation
- M3 Acetylcholine Receptor Stimulation
- Negative Regulators
- Alpha-2 Receptor Stimulation
- Somatostatin
2 mins
Hypoglycemia Intervention
- Interventions
- Mild to Moderate Hypoglycemia
- Simple Carbohydrate (Oral Dextrose, Fruit Juice, Candies)
- Complex Carbohydrate (Whole Grains, Vegetables)
- Severe Hypoglycemia or Unconscious
- 50% Dextrose
- Glucagon
- Considerations
- Monitor Blood Glucose Q 10-15 Minutes
- Give Small Meal After Intervention
- Patient Education
- Hypoglycemia Prevention
- Encourage Self-Monitoring
3 mins
Insulin Function
- Receptors
- Tyrosine Kinase Receptor
- Growth Factor
- Stimulates IGF-1
- Anabolic Effects
- Glucose Uptake in Skeletal Muscle and Adipose
- Inhibits Glucagon Release
- Glycogenesis
- Triglyceride Synthesis
- Cellular Uptake of Potassium and Amino Acids
- Sodium Retention
- Protein Synthesis (Muscles)
4 mins
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