Burkitt's Lymphoma
- Adolescents or young adults
- C-myc gene moves next to heavy chain Ig gene
- T 8;14
- Starry sky appearance
- Sheets of lymphocytes with interspersed macrophages
- Jaw lesion in endemic (African) form
- Pelvis or abdomen in non endemic form (American form)
- Associated with EBV
Follicular Lymphoma
- Derives from Germinal Center
- Occurs in adults
- T14;18
- BCL 2 overexpression
- BCL 2 inhibits apoptosis
- Indolent
- Generalized lymphadenopathy
- Bone marrow involvement
Mantle Cell Lymphoma
- Older Males
- Activation of Cyclin D Gene
- T 11;14
- CD5
- Poor Prognosis
Adult T Cell Lymphoma
- Caused by HTLV 1
- Japan, West Africa, Caribbean
- Present with cutaneous lesions
- Aggressive
Diffuse Large B Cell Lymphoma
- Most Common Non-Hodgkin’s Lymphoma
- Usually in Older Adults
- 20% in Children
- May be Mature T Cell in Origin
- Derives from Germinal Center
- GI Tract and Brain
Hodgkin Lymphoma Signs & Symptoms
- Localized Single Group of Lymph Nodes
- Contiguous Spread
- Constitutional B Symptoms
- Low-Grade Fever
- Night Sweats
- Weight Loss
Hodgkin Lymphoma Pathophysiology
- Reed-Sternberg Cells
- Binucleate
- Owl's Eyes Appearance
- CD 15 and CD 30
- B Cell Origin
- Bimodal Age Distribution
Non-Hodgkin's Lymphoma Assessment
- Lymphatic Cancer
- Non-Contiguous Spread
- B or T Cells
- Painless Lymphadenopathy
- Constitutional B Signs
- Night Sweats
- Fever
- Weight Loss
- Mediastinal or Abdominal Mass
- Older Adults
- > 60 Subtypes
Mycosis Fungoides / Sézary Syndrome
- Neoplastic CD4+ Cells
- Adults 40 - 60 Years Old
- Neoplastic CD4+ Cells Infiltrate Skin
- Rashes Or Plaques
- Pautrier's Abscesses
- Neoplastic CD4+ Spread from Skin to Systemic Involvement
- Sézary Cells With "Cerebriform Nuclei"