Master Medullary Thyroid Carcinoma with Picmonic for Medicine

These neuroendocrine cells within the thyroid gland produce and secrete calcitonin.

Calcitonin is a peptide hormone that has antagonistic effects to parathyroid hormone (PTH); it is secreted in response to high blood calcium levels and its primary function is to lower calcium levels by decreasing absorption in the GI tract, modifying bone resorption, and increasing excretion by the kidneys. By measuring serum levels of calcitonin, it can be used as a tumor marker for medullary carcinoma.

Since calcitonin downregulates calcium in the blood, an excessive amount of calcitonin may produce hypocalcemia, which can manifest as tetany, paresthesias, seizures, and EKG abnormalities.

Adrenocorticotropic hormone is a peptide hormone normally produced by the anterior pituitary gland. Like many other cancers, medullary thyroid carcinomas can produce ectopic ACTH and therefore patients can present with signs and symptoms of Cushing syndrome such as weight gain, hypertension, abdominal striae, etc.

Medullary carcinoma cells arrange themselves into sheets; the cells that form these sheets contain excess calcitonin that is eventually converted into amyloid protein. These amyloid deposits can be stained with Congo Red dye and will exhibit the pathognomonic apple-green birefringence when viewed under polarized light.

As a diagnostic test, a synthetic peptide hormone called Pentagastrin can be administered to a patient in order to stimulate the release of calcitonin from C cells, which can then be measured and compared to baseline levels. Patients with medullary thyroid cancer will have levels markedly above normal or baseline after pentagastrin infusion.

These two subsets of the multiple endocrine neoplasia (MEN) syndromes both involve medullary thyroid cancer and pheochromocytomas. MEN 2A also classically includes parathyroid hyperplasia, while MEN 2B also manifests with mucosal neuromas, or more specifically oral ganglioneuromatosis. Both of these syndromes are inherited in an autosomal dominant fashion via the RET oncogene on chromosome 10.