Lamotrigine is indicated to treat simple and complex partial seizures, as well as generalized tonic-clonic seizures.
Lamotrigine acts as a mood stabilizer and is approved for use as a maintenance agent for Bipolar Type I disorder.
This drug blocks voltage-sensitive Na+ channels, thereby stabilizing neuronal membranes and consequently modulating presynaptic transmitter release of glutamate and aspartate, which are excitatory amino acids.
Lamotrigine can trigger Stevens-Johnson syndrome. Stevens-Johnson syndrome is a life-threatening skin condition, which is a hypersensitivity complex affecting the skin and mucous membranes.
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