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Medicine (MD/DO)
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First Aid
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First Aid for the USMLE Step 1 (2018)
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Page 38 -

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First Aid for the USMLE Step 1 (2018) | Medicine (MD/DO) School Study Aid

Page 38 -
5 Picmonics to Learn | 14 mins
Transcription Overview
Initiation
RNA Polymerase Binds Promoter
Elongation
DNA Opens by Helicase
RNA Polymerase Reads 3' to 5'
Nucleotides Added to 3' End
Termination
Stem Loop Formation
Rho Protein Factor
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3 mins
DNA Replication
Characteristics
DNA Gyrase Uncoils Supercoil
Helicase Separated DNA Strand
Single-Strand Binding (SSB) Protein Keeps Strands Separated
DNA Polymerase Synthesizes New Strand
3' To 5' Reading
Primase Creates RNA Primer
Telomerase Caps DNA Ends
DNA Ligase Combines Okazaki Fragments
Okazaki Fragments On Lagging Strand
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4 mins
DNA Base Pairing
Characteristics
3' End
5' End
Antiparallel Base Pairing
Complementary Strands Pair
Thymine And Adenine Pair
2 Hydrogen Bonds
Adenine and Uracil Pair in RNA
Guanine And Cytosine Pair
3 Hydrogen Bonds
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3 mins
Nucleus
Characteristics
Transcription Factors
Nucleolus Transcribes rRNA
DNA
RNA
Nuclear Membrane is a Bilayer
Membrane is Continuous with Endoplasmic Reticulum
Nucleus Surrounded by Cytosol
Nuclear Pores
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2 mins
De Novo Purine Synthesis
PRPP Synthesis
Ribose-5-Phosphate
PRPP (Phosphoribosyl Pyrophosphate)
IMP Synthesis
Glutamine PRPP Amidotransferase
Phosphoribosylamine
Folate Cofactor
Inosine Monophosphate
AMP Synthesis
Adenosine Monophosphate
Requires GTP
GMP Synthesis
Guanosine Monophosphate
Requires ATP
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4 mins

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