Pyruvate Dehydrogenase Deficiency
- Acquired from Thiamine Deficiency
- Backup of Alanine and Pyruvate
- Neurologic Defects
- Lactic Acidosis
- Ketogenic Nutrients
- Lysine and Leucine (Ketogenic Nutrients)
Citric Acid Cycle (Krebs Cycle)
- Acetyl-CoA + Oxaloacetate
- Citric Acid
- Isocitric Acid
- Produces NADH
- Alpha-Ketoglutaric Acid
- Produces NADH
- Succinyl CoA
- Produces GTP
- Succinate
- Produces FADH2
- Fumarate
- Uses Water
- Malate
- Produces NADH
- Oxaloacetate
Energy Releasing Pathways: Accounting
- Anaerobic Respiration
- 2 ATP
- 2 NADH
- Aerobic Respiration
- 8 NADH
- 2 FADH2
- 2 ATP
- Oxidative Phosphorylation
- 34 ATP
- 2 ATP Lost
- 36 Net Total ATP
Anaerobic Respiration
- Cytosol
- Glucose
- Glycolysis
- Substrate-level Phosphorylation
- 2 NADH
- 2 Net ATP
- 2 Pyruvate
- Fermentation
- NAD+ Regeneration
- Waste Byproduct