Class I Antiarrhythmics (Na+ Channel Blockers) Overview
- Arrhythmias
- Local Anesthesia
- Block or Slow Conduction
- Block Na+ Channels
- Raise Threshold
- State Dependent
- Hyperkalemia
Class IA Antiarrhythmics (Na+ Channel Blockers)
- Arrhythmias
- Increase AP, ERP, and QT interval.
- Disopyramide
- Procainamide
- Drug-induced Lupus
- Quinidine
- Cinchonism
- Thrombocytopenia
- Torsades de Pointes
Class IB Antiarrhythmics (Na+ Channel Blockers)
- Arrhythmias
- After Myocardial Infarction
- Affect Ischemic Tissue
- Decrease AP duration
- Mexiletine
- GI Upset
- Lidocaine
- CNS Depression
- Tocainide
- Phenytoin
- Hirsutism
Class IC Antiarrhythmics (Na+ Channel Blockers)
- Used as Last Resort
- V-Tach
- No Effect on AP Duration
- Propafenone
- Flecainide
- Post-Myocardial Infarction
Lidocaine
- Blocks Na+ Channels
- Ventricular Arrhythmia
- Anesthetic
- Paresthesias
- Seizures
- Respiratory Depression
- Drowsiness
- Anesthetic Effects Extended with Epinephrine