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Medicine (MD/DO)
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First Aid
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First Aid for the USMLE Step 1 (2020)
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First Aid for the USMLE Step 1 (2020) | Medicine (MD/DO) School Study Aid

Page 42 -
4 Picmonics to Learn | 6 mins
Eukaryotic Transcription Regulation
DNA Silencer Region
Transcription Factors bind Silencer Region
Decreased Transcription
Co-factors can deactivate factors
Co-factors can activate factors
DNA Enhancer Region
Transcription Factors bind Enhancer Region
Increased Transcription
Enhancer and Silencer regions can be far from Promoter
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2 mins
Eukaryotic Post Transcriptional Modification
Modifications in Nucleus
mRNA Splicing
Introns Cut Out
Exons spliced together
Alternate Splicing
5' Cap added
3' Poly A tail added
Transported to Cytosol
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2 mins
Dactinomycin (Actinomycin D)
Indications
Wilms' Tumor
Rhabdomyosarcoma
Ewing's Sarcoma
Gestational Trophoblastic Malignancy
Mechanism
Intercalates DNA
Side Effect
Myelosuppression
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1 min
Rifampin
Tuberculosis (TB)
Blocks RNA Polymerization
Haemophilus influenzae Type B
Leprosy
Meningitis
P450 inducer
Red-orange urine
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55 secs

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