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Medicine (MD/DO)
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First Aid
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First Aid for the USMLE Step 1 (2020)
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First Aid for the USMLE Step 1 (2020) | Medicine (MD/DO) School Study Aid

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3 Picmonics to Learn | 7 mins
Pancreatin, Pancrelipase (Pancreatic Enzymes)
Mechanism
Pancreatic Enzymes
Indications
Cystic Fibrosis
Pancreatic Insufficiency
Side Effects
GI Distress
Considerations
Inactivated by Gastric Acid
24 Hour Fat Excretion
Take with Every Meal and Snack
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2 mins
PCSK9-Inhibitors
AVAILABLE DRUGS
Evolocumab
Alirocumab
MECHANISM OF ACTION
Monoclonal Antibodies
Bind the PCSK9 Enzyme
Decreased Degradation of LDL-receptors
Increased LDL Receptors on Hepatocytes
Reduction of LDL in Plasma
INDICATION
Second-line Therapy for Hypercholesterolemia
ADMINISTRATION
Subcutaneous Injection
SIDE EFFECTS
Skin Reaction at the Injection Site
Myalgia
Neurocognitive Impairment
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2 mins
Apolipoprotein Types
E
Mediates Remnant Uptake
AI
Activates LCAT
CII
Catalyzes Cleavage
B48
Mediates Chylomicron Secretion Into Lymphatics
Only on Particles Originating from the Intestine
B100
Binds LDL Receptor
Only on Particles Originating from the Liver
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2 mins

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