Fusion Inhibitors
- HIV
- Maraviroc
- Binds CCR-5 on T Cells
- Blocks Interaction with gp120
- Enfuvirtide
- Binds gp41
- Inhibits Viral Entry
- Skin Reactions at Injection Sites (Enfuvirtide)
NRTIs (Nucleoside Reverse Transcriptase Inhibitors)
- HIV
- Pregnancy and Prophylaxis given ZDV
- Inhibit Nucleotide Binding to Reverse Transcriptase
- Chain Termination
- Require Phosphorylation
NNRTIs (Non-nucleoside Reverse Transcriptase Inhibitors)
- HIV
- Do Not Require Intracellular Metabolism
- Inhibits Reverse Transcriptase
- Rash
- Hepatotoxicity
- Vivid Dreams and CNS Symptoms
- Pregnancy
Integrase Inhibitors
- -gravir Suffix
- HIV
- Blocks Insertion of Viral Genome
- Inhibit Actions of Integrase
- Hypercholesterolemia
- Increased LFT's
- Insomnia
- Increased Creatine Kinase (CK)
Protease Inhibitors
- End in "-navir"
- HIV/AIDS
- Hepatitis C
- Inhibit Protease
- Unable to Cleave Proteins
- Inhibits Maturation of New Virus
- GI Distress
- Nephropathy
- Lipodystrophy
- Hyperglycemia
Zanamivir (Relenza) and Oseltamivir (Tamiflu)
- Influenza A and B
- Treatment and Prophylaxis
- Inhibits Release of New Virus
- Inhibits Influenza Neuraminidase
Acyclovir (Zovirax)
- Guanosine Analog
- Inhibits Viral Replication
- Thymidine Kinase Activation
- Herpes Simplex Virus (HSV)
- Varicella Zoster Virus (VZV)
- Headache
- GI Distress
- CNS Toxicity
- Nephrotoxicity (Crystalline Nephropathy)
- Prevents Recurrent Episodes
- Slow IV Infusion
Ganciclovir
- Cytomegalovirus (CMV)
- Immunocompromised
- Guanosine Analog
- Disrupts DNA Synthesis
- Inhibits Viral DNA Polymerase
- Hematologic Effects
- Nephrotoxicity