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First Aid for the USMLE Step 1 (2021) | Medicine (MD/DO) School Study Aid
Baclofen
- Mechanism
- GABA-B Receptor Agonist
- Spinal Cord
- Indications
- Spasticity
- Dystonia
- Multiple Sclerosis
- Side Effects
- CNS Depression
- Nausea
- Considerations
- Taper Gradually
1 min
Cyclobenzaprine (Flexeril)
- Mechanism
- Centrally-Acting Muscle Relaxer
- Act on Alpha and Gamma Motor Neurons
- Related to Tricyclic Antidepressants (TCAs)
- Uses
- Muscle Spasms
- Back Pain
- Side Effects/Interactions
- MAO Inhibitors
- Serotonin Syndrome
- Drowsiness
- Arrhythmia
3 mins
Malignant Hyperthermia
- Inheritance
- Autosomal-Dominant
- Pathophysiology and causes
- Ryanodine Receptor 1 Mutation
- Inhaled Anesthetics
- Succinylcholine
- Symptoms
- Autonomic Instability
- Muscle Rigidity
- Treatment
- Dantrolene
2 mins
Neuroleptic Malignant Syndrome
- FEVER Acronym
- Fever
- Encephalopathy
- Vital Signs Unstable
- Elevated Enzymes
- Rigidity of muscles
- Reversal Agent
- D2 Agonists
- Bromocriptine
- Dantrolene
2 mins
Malignant Hyperthermia vs. Neuroleptic Malignant Syndrome vs. Serotonin Syndrome
- Autonomic Instability
- Muscle Rigidity
- Malignant Hyperthermia
- Ryanodine Receptor 1 Mutation
- Inhaled Anesthetics
- Succinylcholine
- Dantrolene
- Neuroleptic Malignant Syndrome
- Antidopaminergic Medications
- Hyporeflexia
- Myoglobinuria
- Dantrolene
- Serotonin Syndrome
- Serotonergic Medications
- Hyperreflexia
- Clonus
- Cyproheptadine
3 mins
Opioids Overview
- Indications
- Pain
- Weaning
- Cough
- Diarrhea
- Mechanism of Action
- Agonists at Mu (μ), Kappa (Κ), and Delta (δ) Receptors
- Decrease Synaptic Transmission
- Side Effects
- Respiratory Depression
- Addiction
- Miosis
- Constipation
2 mins
Opioid Antidote
- Antidote
- Naloxone
29 secs
Naloxone (Narcan)
- Mechanism
- Competitive Opioid Receptor Antagonist
- Indications
- Opioid Induced CNS Depression
- Side Effects
- Severe Nausea and Vomiting
- Excitable State
- Opioid Withdrawal Symptoms
- Considerations
- Repeated Dosing Often Required
1 min
Opioid Use Disorder and Withdrawal Assessment (Formerly Opioid Abuse and Withdrawal Assessment)
- Abuse Assessment
- Euphoria
- Miosis
- CNS Depression
- Abuse Withdrawal
- Yawning
- Gooseflesh
- Sweating
- Rhinorrhea
- Kicking Movements
- Consideration
- Naloxone
1 min
Buprenorphine-Naloxone (Suboxone)
- Mechanism of Action
- Combination Drug
- Partial Opioid Receptor Agonist (Buprenorphine)
- Opioid Receptor Antagonist (Naloxone)
- Indication
- Opioid Use Disorder
- Side Effects
- CNS Depression
- Diaphoresis
- Hypotension
- Considerations
- Low Abuse Potential
2 mins
Codeine
- Mechanism
- Opioid Receptor Agonist
- Indications
- Mild to Moderate Pain
- Cough Suppressant
- Side Effects
- Sedation
- Constipation
- Miosis
- Considerations
- Close Monitoring When Breast Feeding
- Often Combined with Non-Opioids
2 mins
Oxycodone
- Mechanism of Action
- Opioid Receptor Agonist
- Indication
- Refractory Pain
- Side Effects
- Respiratory Depression
- Constipation
- CNS Depression
- Considerations
- Addiction
- Naloxone
2 mins
Fentanyl
- Mechanism of Action
- Opioid Receptor Agonist
- High Potency
- Indications
- Anesthesia Induction
- Chronic Pain
- Breakthrough Pain
- Side Effects
- CNS Depression
- Respiratory Depression
- Constipation
- Miosis
- Considerations
- Addiction
3 mins
Morphine
- Mechanism
- Opioid Receptor Agonist
- Indications
- Pain
- Myocardial Infarction
- Side Effects
- Nausea and Vomiting
- CNS Depression
- Biliary Colic
- Constipation
- Increased Intracranial Pressure (ICP)
- Pupillary Constriction
- Hypotension
2 mins
Meperidine (Demerol)
- Mechanism
- Opioid Receptor Agonist
- Indications
- Moderate to Severe Pain
- Post Anesthesia Shivering
- Side Effects
- Tremors
- Constipation
- CNS Depression
- Sedation
- Considerations
- Short Term Administration
- Increased Risk Serotonin Syndrome
- Does NOT cause Miosis
- Renal Failure Increases Toxicity Risk
2 mins
Alcohol Use Disorder Interventions (Formerly Alcohol Abuse Interventions)
- Withdrawal
- Reduce Environmental Stimuli
- Antianxiety Medications
- Vitamin Supplements
- Seizure Precautions
- Suicide Precautions
- Fever
- Considerations
- Identify Support Systems
- Group Therapy
- Disulfiram
- Naltrexone
2 mins
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