Polycythemia Vera Disease
- JAK2 Mutation leading to increased red blood cells
- Tyrosine Kinase
- Erythromelalgia
- Pruritus
- Often After Hot Shower
- Headache
- Phlebotomy
- Aspirin
Polycythemia Vera Labs
- Hypervolemia
- Histaminemia
- Hyperviscosity
- Hyperuricemia
- Elevated Hemoglobin or Hematocrit
- Positive Jak2 Mutation
Primary Myelofibrosis
- Bone Marrow Fibrosis
- Extramedullary Hematopoiesis
- JAK2 Kinase Mutation
- Fatigue
- Weight Loss
- Splenomegaly
- Pancytopenia
- Dacrocytes (Teardrop Cells)
- Dry Tap on Bone Marrow Aspiration
- Stem Cell Transplantation
- Transfusion
- Ruxolitinib (JAK2 Inhibitor)
Essential Thrombocythemia
- JAK2 Mutation
- Often Asymptomatic
- Thromboembolic Events
- Spontaneous Abortion
- Erythromelalgia
- Gout
- Thrombocytosis
- Megakaryocyte Hyperplasia
- Aspirin
- Hydroxyurea
Chronic Myelogenous Leukemia (CML)
- BCR-ABL
- 9;22 Translocation
- Philadelphia Chromosome
- Tyrosine Kinase
- Low Alkaline Phosphatase
- Splenomegaly
- Blast Crisis
- Age 30 to 90 Years
- Responds to Imatinib