Ace Your First Aid for the USMLE Step 1 (2023) Classes and Exams with Picmonic: #1 Visual Mnemonic Study Tool for Medicine (MD/DO) Students
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First Aid for the USMLE Step 1 (2023) | Medicine (MD/DO) School Study Aid
De Novo Purine Synthesis
- PRPP Synthesis
- Ribose-5-Phosphate
- PRPP (Phosphoribosyl Pyrophosphate)
- IMP Synthesis
- Glutamine PRPP Amidotransferase
- Phosphoribosylamine
- Folate Cofactor
- Inosine Monophosphate
- AMP Synthesis
- Adenosine Monophosphate
- Requires GTP
- GMP Synthesis
- Guanosine Monophosphate
- Requires ATP
4 mins
Leflunomide
- Use And Mechanism
- Immunosuppressant Used In Rheumatoid Arthritis
- DMARD
- Inhibits Dihydroorotate Dehydrogenase
- Blocks Pyrimidine Synthesis And T-Cell Proliferation
- Adverse Effects
- Hepatotoxicity
- Bone Marrow Suppression
- GI Upset
- Alopecia
4 mins
Fluorouracil (5-FU)
- Mechanism
- Antimetabolite
- "Thymine-less Death"
- Indications
- Slow-growing Solid Tumors
- Co-administered with Leucovorin for Stomach Cancer
- Basal Cell Carcinoma (Topical)
- Side Effects
- Myelosuppression
- Mucositis
- Severe Diarrhea
3 mins
Azathioprine (Imuran)
- Mechanism
- Antimetabolite
- Prodrug of 6-mercaptopurine (6-MP)
- Inhibits Synthesis of Nucleic Acids
- Indications
- Autoimmune Disorders
- Kidney Transplantation
- Side Effects
- Myelosuppression
- Increased Toxicity with Allopurinol Use
- Pancreatitis
- Malignancy
3 mins
Ribavirin
- Mechanism
- Hypermutation in RNA Viruses
- Inhibits Inosine Monophosphate Dehydrogenase
- Indications
- Hepatitis C
- Viral Hemorrhagic Fevers
- Respiratory Syncytial Virus (RSV)
- Side Effects
- Hemolytic Anemia
- Teratogen
1 min
Hydroxyurea
- Mechanism
- Inhibits Ribonucleotide Reductase
- Decreased DNA Synthesis
- S-phase Specific
- Indications
- Melanoma
- Chronic Myelogenous Leukemia (CML)
- Sickle Cell Disease
- Through Increased HbF (Fetal Hemoglobin)
- Side Effects
- Myelosuppression
- GI Distress
2 mins
Methotrexate
- Indications
- Rheumatoid Arthritis
- Cancer
- Medical Abortion
- Mechanism
- Folic Acid Analog
- Inhibits Dihydrofolate Reductase
- Side Effects
- Pulmonary Fibrosis
- Myelosuppression is Treated with Leucovorin Rescue (Folinic Acid)
- Macrocytic Anemia
- Hepatitis
- Teratogenic
- Mucositis
2 mins
Trimethoprim
- Mechanism of Action
- Bacteriostatic
- Inhibits Bacterial Dihydrofolate Reductase
- Causes Sequential Block of Folate Synthesis
- Used in Combination with Sulfamethoxazole
- Combination Used For Recurrent Urinary Tract Infections
- Indications
- Shigella
- Salmonella
- Pneumocystis Jiroveci Pneumonia
- Side Effects
- Decrease in Red and White Blood Cells
- Alleviated with Leucovorin Rescue
2 mins
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