Cyclosporine (Sandimmune) Overview
- Immunosuppressant
- Inhibits Calcineurin, Decreasing IL-2
- Prevent Transplant Rejection
- Psoriasis
- Rheumatoid Arthritis
- Monitor Plasma Levels
- Avoid Grapefruit Juice
- Increased Risk of Lymphoma
Cyclosporine (Sandimmune) Side Effects
- Nephrotoxicity
- Hepatotoxicity
- Infection
- Hypertension
- Hirsutism
- Tremor
- Hyperkalemia
- Hypomagnesemia
- Gingival Hyperplasia
Tacrolimus (Prograf) Overview
- Immunosuppressant
- Inhibits Calcineurin, Decreasing IL-2
- Transplant Rejection
- Atopic Dermatitis
- Increased Lymphoma Risk
- Avoid Grapefruit Juice
Tacrolimus (Prograf) Side Effects
- Nephrotoxicity
- Neurotoxicity
- GI Distress
- Infection
- Hypertension
- Hyperkalemia
- Hyperglycemia
Sirolimus
- mTOR Inhibitor
- Inhibits T-cell Activation
- Inhibits B-cell Differentiation
- Drug Eluting Stents
- Kidney Transplant Rejection Prophylaxis
- Pancytopenia
- Insulin Resistance
- Hyperlipidemia
Azathioprine (Imuran)
- Antimetabolite
- Prodrug of 6-mercaptopurine (6-MP)
- Inhibits Synthesis of Nucleic Acids
- Autoimmune Disorders
- Kidney Transplantation
- Myelosuppression
- Increased Toxicity with Allopurinol Use
- Pancreatitis
- Malignancy
Prednisone (Glucocorticoids)
- Glucocorticoid
- Inflammatory Conditions
- Organ Transplant Rejection
- Cataracts and Glaucoma
- Cushing's Syndrome
- Osteoporosis
- Immunosuppression
- Hyperglycemia
- Ulcers
- Adrenal Insufficiency
- Taper Gradually