Ace Your First Aid for the USMLE Step 1 (2023) Classes and Exams with Picmonic: #1 Visual Mnemonic Study Tool for Medicine (MD/DO) Students
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First Aid for the USMLE Step 1 (2023) | Medicine (MD/DO) School Study Aid
Erlotinib
- Mechanism of Action
- Inhibits EGFR Tyrosine Kinase
- Inhibits Progression of G1 to S Phase
- Indications
- Non-small Cell Lung Cancer (NSCLC)
- Pancreatic Cancer
- Side Effects
- Rash
- Diarrhea
- Considerations
- Avoid Grapefruit Juice
1 min
Imatinib (Gleevec)
- Indications
- Chronic Myelogenous Leukemia (CML)
- Inhibitor of BCR-ABL Tyrosine Kinase
- Caused by Philadelphia Chromosome
- GI Stromal Tumors
- Inhibitor of C-kit Tyrosine Kinase
- Toxicity
- Fluid Retention
1 min
BRAF Inhibitors
- Characteristics
- BRAF Proto-oncogene
- Serine/Threonine Kinase
- V600E Mutation
- Indications
- Melanoma
- Non-Hodgkin Lymphoma
- Papillary Thyroid Carcinoma
- Hairy Cell Leukemia
- Drugs
- Dabrafenib
- Vemurafenib
2 mins
Cisplatin
- Indications
- Carcinomas
- Ovarian
- Bladder
- Lung
- Testicular
- Mechanism
- Cross-Links DNA
- Side Effects
- Ototoxicity
- Nephrotoxicity
- Treat with Amifostine and Chloride Diuresis
2 mins
Doxorubicin (Adriamycin)
- Indications
- Solid Tumors
- Lymphomas and Leukemias
- Mechanism
- Free Radical Production
- Intercalates DNA
- Prevents Double Helix from Sealing
- Side Effect
- Cardiotoxicity
- Dexrazoxane Decreases Toxicity
1 min
Fluorouracil (5-FU)
- Mechanism
- Antimetabolite
- "Thymine-less Death"
- Indications
- Slow-growing Solid Tumors
- Co-administered with Leucovorin for Stomach Cancer
- Basal Cell Carcinoma (Topical)
- Side Effects
- Myelosuppression
- Mucositis
- Severe Diarrhea
3 mins
Cyclophosphamide
- Mechanism
- Requires Bioactivation by Liver
- Cross-links DNA
- Guanine N7 Position
- Indications
- Autoimmune Disorders
- Leukemia
- Lymphoma
- Solid Tumors
- Side Effects
- Myelosuppression
- Hemorrhagic Cystitis
- Prevent with Mesna
3 mins
Rasburicase
- Characteristics
- Recombinant Uricase
- Converts Uric Acid to Allantoin
- Inidication
- Hyperuricemia
- Tumor Lysis Syndrome
- Side Effects
- Hypersensitivity Reaction
- Methemoglobinemia
- Considerations
- Contraindicated in G6PD Deficiency
1 min
Ondansetron
- Indications
- Postoperative Vomiting
- Chemotherapy-induced Nausea and Vomiting
- Mechanism
- 5-HT3 Serotonergic Antagonist
- Centrally-acting Antiemetic
- Side Effects
- Headache
- Constipation
- QT Prolongation
1 min
Metoclopramide
- Indications
- Antiemetic
- Promotility Agent
- Mechanism
- Increased Resting Tone
- Antagonist at D2 Receptor
- Side Effects
- Parkinsonian Symptoms
- Galactorrhea
- Contraindication
- Small Bowel Obstruction
- Parkinson's Disease
2 mins
Erythropoietin
- Mechanism
- Stimulates RBC Production
- Indications
- Chronic Renal Failure
- Anemia
- Side Effects
- Increased Risk of Thrombosis
- Pelvic and Limb Pain
- Hypertension
- Considerations
- Do Not Shake
- Monitor Hemoglobin (Hgb) Weekly
- May Accelerate Tumor Progression
2 mins
