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Medicine (MD/DO)
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First Aid
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First Aid for the USMLE Step 1 (2023)
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First Aid for the USMLE Step 1 (2023) | Medicine (MD/DO) School Study Aid

Page 606 -
6 Picmonics to Learn | 19 mins
Fanconi Syndrome Characteristics
Pathophysiology
Resorption Defect in Proximal Tubule
Signs and Symptoms
Hypophosphatemia
Rickets
Osteomalacia
Hypokalemia
Metabolic Acidosis
Type 2 Renal Tubular Acidosis
Treatment
Treat Underlying Disorder
Bicarbonate
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1 min
Fanconi Syndrome Causes
Hereditary Causes
Cystinosis
Dent's Disease
Wilson's Disease
Oculocerebrorenal (Lowe) Syndrome
Galactosemia
Hereditary Fructose Intolerance
Glycogen Storage Diseases
Tyrosinemia
Acquired and Medication Causes
Tenofovir
Heavy Metals
Expired Tetracyclines
Cisplatin
Gentamycin (Aminoglycosides)
Valproate Sodium
Multiple Myeloma
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2 mins
Bartter Syndrome
Pathophysiology
Autosomal Recessive
Thick Ascending Limb of Loop of Henle
Defective NKCC Cotransporter
Decreased Na+ Reabsorption
Decreased Ca2+ Reabsorption
Increased Aldosterone
Clinical Features
Hypovolemia
Polyuria and Polydipsia
Metabolic Alkalosis
Mimics Loop Diuretics
Nephrolithiasis
Treatment
Spironolactone (Aldactone)
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4 mins
Gitelman Syndrome
Pathophysiology
Autosomal Recessive
Defective Sodium-Chloride Cotransporter in Distal Tubule
Mechanism Mimics Thiazide Diuretics
Clinical Presentation
Cramping and Tetany
Severe Fatigue
Polyuria
Diagnosis
Hypokalemia
Metabolic Alkalosis
High Urine Chloride
Treatment
Electrolyte Supplements
Spironolactone
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4 mins
Liddle Syndrome
Pathophysiology
Autosomal Dominant
Collecting Duct
Gain of Function Mutation in Epithelial Sodium Channel (ENaC)
Excess Na+ and H2O Reabsorption
Clinical Features
Decreased Renin
Decreased Aldosterone
Hypertension with Hypokalemia
Metabolic Alkalosis
Pseudohyperaldosteronism
Treatment
Amiloride and Triamterene
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3 mins
Syndrome Of Apparent Mineralocorticoid Excess (SAME)
Pathophysiology
11 Beta-Hydroxysteroid Dehydrogenase Deficiency
Elevated Cortisol
Low Renin
Low Aldosterone
Causes
Autosomal-Recessive
Licorice (glycyrrhetinic acid) Ingestion
Signs & Symptoms
Hypertension
Hypokalemia
Metabolic Alkalosis
Treatment
Potassium-Sparing Diuretics
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4 mins

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