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Medicine (MD/DO)
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First Aid
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First Aid for the USMLE Step 2 CK (10th Ed.)
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Reproductive Endocrinology

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First Aid for the USMLE Step 2 CK (10th Ed.) | Medicine (MD/DO) School Study Aid

Reproductive Endocrinology
8 Picmonics to Learn | 14 mins
21 Hydroxylase Deficiency
Pathophysiology
Decreased Cortisol
Increased 17 Hydroxyprogesterone
Decreased Aldosterone
Signs and Symptoms
Hypotension
Increased Renin
Hyperkalemia
Female Pseudohermaphroditism
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2 mins
11 Beta-Hydroxylase Deficiency
Pathophysiology
Decreased Cortisol
Decreased Aldosterone
Increased Sex Hormones
Increased 11 Deoxycorticosterone (11 DOC)
Signs and Symptoms
Hypertension
Masculinization
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1 min
17 Alpha Hydroxylase Deficiency
Decreased Cortisol
Decreased Sex Hormones
Increased Mineralocorticoids (DOC)
Hypertension
Hypokalemia
XY Externally Phenotypic Female
No Internal Reproductive Structures Due to Mullerian Inhibitory Factor
XX Externally Phenotypic Female
Sexual Infantilism
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2 mins
Polycystic Ovarian Syndrome (PCOS) Mechanism
Mechanism
Hyperinsulinemia Increases GnRH Pulse Frequency
Large Increase in LH
Small Decrease in FSH
Increased Androgen Production From Theca-Lutein Cells
Decreased Steroid Hormone-Binding-Globulin (SHBG) Causes Increased Free Testosterone
Obese Patients Have Increased Estrogen
Increased Risk of Endometrial Cancer
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2 mins
Polycystic Ovarian Syndrome (PCOS) Symptoms and Diagnosis
Symptoms
Most Common Cause of Infertility in Women
Amenorrhea
Acne
Hirsutism
Obesity
Diagnosis
Enlarged, Cystic Ovaries
LH:FSH Ratio of 3:1
"String of Pearls" on Ultrasound
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1 min
Polycystic Ovarian Syndrome (PCOS) Treatment
Weight Loss
Oral Contraceptives
Clomiphene Citrate
Anti-androgens
Cyclic Progesterone for Endometrial Protection
Metformin
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1 min
Infertility
No Conception After 1 Year
Interventions
Artificial Insemination
In Vitro Fertilization (IVF)
Drug Therapy
Clomiphene Citrate (Clomid)
Menotropins
GnRH Agonists
Considerations
Treat Underlying Disorders
Emotional Support
Multiple Gestations
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3 mins
Fludrocortisone
Mechanism of Action
Aldosterone Analog
Indications
Addison’s Disease (Primary Adrenal Insufficiency)
Congenital Adrenal Hyperplasia
Side Effects
Cushing Syndrome
Edema
Congestive Heart Failure Exacerbation
Hyperpigmentation
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2 mins

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