Ace Your First Aid for the USMLE Step 2 CK (8th Ed.) Classes and Exams with Picmonic: #1 Visual Mnemonic Study Tool for Medicine (MD/DO) Students
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First Aid for the USMLE Step 2 CK (8th Ed.) | Medicine (MD/DO) School Study Aid
Hypersensitivity Type I
- Previous Antigen Exposure
- Immediate Reaction
- IgE Cross-linking
- Presensitized Mast Cells
- Histamine Release
- Vasodilation
- Anaphylaxis
- Allergies
- Treatment
- Epinephrine
1 min
Hypersensitivity Type II
- Cytotoxic
- IgM or IgG antibody-mediated
- Membrane Attack Complex (MAC)
- Mechanism
- Opsonization
- Complement Activation
- NK Cells
- Testing
- Direct Coombs test
- Indirect Coombs Test
1 min
Hypersensitivity Type III
- Immune Complex
- Antigen-antibody (IgG) complex activates complement
- Neutrophils release lysozomal enzymes
- Examples
- Arthus Reaction
- Serum Sickness
- Systemic Lupus Erythematosus (SLE)
1 min
Hypersensitivity Type IV
- Delayed-Type Hypersensitivity
- T Cell Mediated
- Antibody Independant
- Macrophages Activated
- Examples
- Transplant Rejection
- PPD Skin Test
- Contact Dermatitis
1 min
Stevens-Johnson Syndrome
- Etiologies
- Drugs
- Symptoms
- < 10% of Body Surface Area (BSA) Involved
- 10-30% BSA Overlaps with Toxic Epidermal Necrolysis (TEN)
- Fever
- Affects Skin and Mucous Membranes
- Bullae Formation
- Necrosis
- Sloughing of Skin
- High Mortality Rate
- Treatment
- Supportive Care
- IVIG (Intravenous Immunoglobulin)
3 mins
Erythema Nodosum
- Pathophysiology
- Panniculitis
- Painful Inflammation
- Subcutaneous Fat
- Anterior Shins
- Risk Factors
- Coccidioidomycosis
- Pregnancy or OCP Use
- Crohn's Disease
- Tuberculosis (TB)
- Histoplasmosis
- Sarcoidosis
- Ulcerative Colitis
2 mins
Herpes Simplex Virus (HSV)
- Characteristics
- Enveloped
- Double Stranded DNA
- Linear
- Signs and Symptoms
- Type 1 HSV
- Gingivostomatitis
- Keratoconjunctivitis
- Encephalitis of Temporal Lobes
- Latent in Trigeminal Ganglia
- Type 2 HSV
- Genital Vesicles
- Neonatal Herpes
- TORCHES
- Latent in Sacral Ganglia
- Diagnosis
- Tzanck Test
- Multinucleated Giant Cells
- Cowdry A Inclusions
- Treatment
- Acyclovir
2 mins
Bullous Pemphigoid
- Linear Deposits of IgG
- Affects Hemidesmosomes
- Epidermal Basement Membrane
- Tense Blisters on Skin
- Nikolsky Negative
- Contain Eosinophils
- Rarely Affect Oral Mucosa
2 mins
Varicella Zoster Virus (VZV)
- Herpesvirus 3
- Characteristics
- Enveloped
- Double Stranded DNA
- Signs and Symptoms
- Chickenpox
- Pneumonia
- Encephalitis
- Trigeminal and Dorsal Root Ganglia
- Shingles
- Diagnosis
- Tzanck Test
- Multinucleated Giant Cells
- Cowdry A Inclusion
- Treatment
- Acyclovir
2 mins
Human Papillomavirus (HPV)
- Characteristics
- Non-enveloped
- Circular
- Double Stranded DNA
- Disease
- Warts 1, 2, 6, 11
- Condyloma acuminata
- Type 16, 18
- Cervical Carcinoma
- Penile Carcinoma
- AIDS/Immunocompromised
- Worsened by Smoking
- Diagnosis
- Koilocytic change in squamous epithelium
- Pyknotic Nuclei Surrounded by Clear Halo
- Treatment
- Vaccine Available
4 mins
Pox Virus
- Characteristics
- Enveloped
- Double-Stranded DNA
- Linear
- Non-Icosahedral
- Signs and Symptoms
- Smallpox
- Cowpox
- Molluscum Contagiosum
- Umbilicated Flesh-Colored Domed Lesions
1 min
Pityriasis Versicolor (Tinea versicolor)
- Mechanism
- Lipid-Dependent Fungus
- Fatty Acids Damage Melanocytes
- Malassezia Furfur
- Hot, Humid Weather
- Signs and Symptoms
- Hypopigmentation
- Hyperpigmented Patches
- Diagnosis
- Spaghetti and Meatball Appearance on KOH Prep
- Fragmented Hyphae with Clusters of Yeast
- Treatment
- Topical or Oral Antifungals
- Selenium Sulfide
- Zinc
4 mins
Lichen Planus
- Pathophysiology
- Mucocutaneous Disorder
- 30-60 year olds
- Signs & Symptoms
- Pruritic
- Plaques or Papules
- Purple & Polygonal
- Often Mucosal or Genital Involvement
- Wickham Striae
- Diagnosis
- Biopsy
- Sawtooth Infiltrate of Lymphocytes
- Treatment
- Topical Corticosteroids
- Considerations
- Hepatitis C Association
2 mins
Pityriasis Rosea
- Preceded by Upper Respiratory Tract Infection
- Single "Herald Patch"
- "Christmas Tree" Distribution
- Plaques with Collarette Scale
- Self-resolving in 6-8 Weeks
2 mins
Actinic Keratosis
- Sun Exposure
- Papules or Plaques
- Small, Rough
- Erythematous
- Precursor to Squamous Cell Carcinoma
53 secs
Melanoma Diagnosis
- Signs
- ABCDE Mnemonic
- Asymmetry
- Border irregularity
- Color variation
- Diameter > 6mm
- Evolution over time
- Diagnosis
- S-100 Tumor Marker
- LDH (Lactate Dehydrogenase) Screens for Metastasis
- Treatment
- Wide Local Excision
- Adjuvant Therapy
1 min
Melanoma Mechanism and Characteristics
- Mechanism
- Associated with Sunlight Exposure
- Mutation in B-RAF kinase
- Large Number of Moles
- Fair-Skinned People at Higher Risk
- Growth Phases
- Radial Growth Phase
- No Metastasis
- Vertical Growth Phase
- Depth of Tumor Correlates with Risk of Metastasis
1 min
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