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First Aid for the USMLE Step 2 CK (8th Ed.)/
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First Aid for the USMLE Step 2 CK (8th Ed.) | Medicine (MD/DO) School Study Aid
Isoniazid
- Indications
- Tuberculosis (TB)
- Mechanism of Action
- Requires Catalase Peroxidase
- Decreases Mycolic Acid Synthesis
- Fast vs Slow Acetylators
- Side Effects
- B6 Deficiency
- Neurotoxicity
- Hepatotoxicity
- Drug-induced Lupus
1 min
Borrelia burgdorferi
- Characteristics
- Lyme Disease
- Spirochete
- Dark-field Microscopy
- Giemsa Stain
- Silver Stain
- White-footed Mouse
- Ixodes Tick
- Babesia
- Anaplasmosis
- Signs & Symptoms
- Flu-like Symptoms
- Erythema Migrans
- Bulls Eye Rash
- Bilateral Bell's Palsy
- Conduction Defects
- Arthropathy
- Treatments
- Doxycycline
- Ceftriaxone
3 mins
Chlamydia Characteristics
- Characteristics
- Cannot Make ATP
- Elementary Body Infects
- Intraepithelial
- Reticulate Body Replicates
- Diagnosis
- Cell Wall Lacks Muramic Acid
- Giemsa Stain
- Inclusion Bodies
- Treatment
- Doxycycline (Preferred)
- Azithromycin
2 mins
Chronic Mucocutaneous Candidiasis
- Mechanism and Characteristics
- T Cell Dysfunction
- Candida Albicans
- Signs and Symptoms
- Infections of Skin
- Infections of Mucous Membrane
- Susceptible to HPV Infections like Condyloma Acuminatum
42 secs
Coccidioidomycosis
- Characteristics
- Fungi
- Dimorphic
- Southwest
- After earthquakes
- Spherule
- 20-60 um
- Signs and Symptoms
- Pneumonia
- Meningitis
- Bone Infection
- Skin infections
- Erythema Nodosum
- Granulomatous Inflammation
- Caseous Necrosis
2 mins
Cryptococcus neoformans
- Characteristics
- Monomorphic
- Encapsulated
- Polysaccharide Capsule
- Narrow-Based Buds
- Latex Agglutination
- Pigeons
- India Ink
- Mucicarmine stain
- Signs and Symptoms
- AIDS/Immunocompromised
- Meningitis
- Soap Bubble Lesions in Brain
- Pneumonia
- Treatment
- Fluconazole
- Flucytosine
- Amphotericin
3 mins
Cytomegalovirus (CMV)
- Characteristics
- Enveloped
- Double Stranded DNA
- Herpesvirus 5
- Diagnosis
- Non Heterophile Antibodies
- Owl's eye inclusions
- Signs and Symptoms
- Congenital TORCH infection
- Mononucleosis
- Pneumonia
- AIDS retinitis and esophagitis
- Infection in transplant recipients
2 mins
Mycoplasma Pneumoniae
- Characteristics
- No Cell Wall and No Gram Stain
- Cholesterol Membrane
- Eaton's Agar
- Mulberry Colonies
- Disease
- Atypical pneumonia
- Military Recruits
- Cold IgM Autoimmune Hemolytic Anemia
- Erythema Multiforme
- Treatment
- Tetracycline
- Erythromycin
2 mins
Toxoplasma gondii TORCH
- Signs and Symptoms
- Congenital TORCH Infection
- Mom Usually Asymptomatic
- Rarely Lymphadenopathy
- Nonspecific TORCH Signs
- Intrauterine Growth Retardation
- Hepatosplenomegaly
- Deafness
- Chorioretinitis
- Hydrocephalus
- Diagnosis
- Calcifications
1 min
Toxoplasma gondii
- Characteristics
- Protozoa
- Cysts in Meat or Cat Feces
- Signs and Symptoms
- Brain Abscess in HIV Patients
- Ring-enhancing Brain Lesions
- Crosses Placenta in Pregnant Women
- Congenital TORCH Infection
- Treatment
- Pyrimethamine
- Sulfadiazine
2 mins
Pneumocystis jirovecii
- Fungi
- AIDS/Immunocompromised
- Fever
- Hypoxemia
- Bronchoalveolar Lavage
- Biopsy
- Methenamine Silver Stain
- Saucer/cup shaped yeast forms
- Diffuse interstitial pneumonia CXR
- TMP-SMX
- Start prophylaxis when CD4 drops under 200
1 min
Epstein Barr Virus Mononucleosis
- Mononucleosis
- Fever
- Hepatomegaly
- Splenomegaly
- Pharyngitis
- Posterior Cervical Lymphadenopathy
- Atypical Lymphocytes
- Heterophile Antibodies
- Rash Develops if treated with Ampicillin
- Hodgkin's Lymphoma
2 mins
Histoplasmosis
- Fungi
- 2-5 um
- Yeast Cells within Macrophages
- Starling Bird Poop
- Bat Poop
- Caves
- Mississippi and Ohio River Valleys
- Pneumonia
- Caseating Granuloma
- Erythema Nodosum
1 min
Epstein Barr Virus
- Characteristics
- Herpesvirus 4
- Double Stranded DNA
- Linear
- Enveloped
- Signs and Symptoms
- Infectious Mononucleosis
- Virus Attaches to CD21 in B Cells
- Nasopharyngeal Carcinoma
- Burkitt's Lymphoma
- Hodgkin's Lymphoma
1 min
Ethambutol
- Mechanism of Action
- Bacteriostatic
- Blocks Arabinosyltransferase
- Arabinosyltransferase Polymerizes Carbohydrates
- Carbohydrate Polymers Make Mycobacterium TB Cell Wall
- Side Effects
- Red/Green Color Blindness
- Reversible with Drug Discontinuation
40 secs
Rifampin
- Tuberculosis (TB)
- Blocks RNA Polymerization
- Haemophilus influenzae Type B
- Leprosy
- Meningitis
- P450 inducer
- Red-orange urine
55 secs
Candida Albicans
- Fungi
- Yeast with Pseudohyphae at 20 Degrees C
- Germ Tube Formation at 37 Degrees C
- Pruritic Vaginitis
- White Cottage Cheese Discharge
- Fiery Red Mucosa
- Diabetics
- Antibiotic Use
- Esophageal Thrush in Immunocompromised
- Diaper Rash
- Endocarditis in IV Drug Users
2 mins
Chlamydia trachomatis
- Characteristics
- A to C
- Trachoma
- Follicular Conjunctivitis
- Blindness
- Africa
- L1 to 3
- Lymphogranuloma venereum
- Buboes
- Genital Ulcer
- D to K
- Urethritis and PID
- Neonatal Pneumonia
- Staccato Cough
- Neonatal Conjunctivitis
2 mins
Mycobacterium Tuberculosis Characteristics
- Characteristics
- Mycolic Acid Cell Wall
- Acid-fast
- Carbolfuchsin Stain Red
- Lowenstein-Jensen Agar
- Serpentine Cord Factor
- Primary TB
- Primary TB
- Caseating Granuloma
- Ghon Focus
- Hilar Lymph Nodes
- Ghon Complex
- Reactivation TB
- Reactivation TB
- Reactivation in Apex
3 mins
Mycobacterium Tuberculosis Disease
- CONSTITUTIONAL SYMPTOMS/PULMONARY TUBERCULOSIS
- Fever
- Night Sweats
- Weight Loss
- Hemoptysis
- EXTRA-PULMONARY TUBERCULOSIS
- Extrapulmonary Disease
- Addison's Disease
- CNS
- Liver
- Kidneys
- GI
- Bones
- Pott's Disease
3 mins
Streptococcus Pneumoniae Disease
- Signs and Symptoms
- Sickle Cell Anemia
- Sepsis in Patients with Splenectomy
- Rusty Sputum
- MOPS
- Meningitis
- Otitis Media
- Pneumonia
- Sinusitis
2 mins
Pseudomonas Aeruginosa Disease
- Signs and Symptoms
- Pneumonia
- Cystic Fibrosis
- Burn Wounds
- Hot tub folliculitis
- Urinary Tract Infections
- Osteomyelitis associated with IV drug use
- Osteomyelitis from Shoe Puncture Wound
- Diabetic Osteomyelitis
- Corneal Infections in contact lens users
- Endocarditis
- Ecthyma Gangrenosum
3 mins
Legionella Disease
- Signs and Symptoms
- High Fever
- Diarrhea
- Increased Liver Enzymes
- Hyponatremia
- Type IV Renal Tubular Acidosis
- Severe Atypical Pneumonia
- Pontiac Fever
- Treatment
- Fluoroquinolones
- Macrolides
2 mins
Staphylococcus aureus Disease
- Skin Infections
- Impetigo
- Abscesses
- Exfoliative Toxin
- Scalded Skin Syndrome
- Toxic Shock Syndrome (TSST 1)
- Binds to MHC II and T Cell Receptor
- Food Poisoning
- Acute Bacterial Endocarditis
- Pneumonia
- Osteomyelitis
2 mins
Streptococcus Pneumoniae Characteristics
- Characteristics
- Gram-Positive
- Diplococci
- Lancet-Shaped
- Catalase-Negative
- Optochin-Sensitive
- Bile Soluble
- Alpha-Hemolytic
- Polysaccharide Capsule
- Positive Quellung Reaction
- IgA Protease
1 min
Streptococcus pyogenes Characteristics
- Characteristics
- Group A Streptococci (GAS)
- Gram-Positive
- Cocci
- Beta-Hemolytic
- Catalase-Negative
- Bacitracin-Sensitive
- Hyaluronic Acid Capsule
- Streptolysin O
- DNase
- Streptokinase
- Exotoxin A
- Pyrrolidonyl Arylamidase (PYR) Positive
2 mins
Streptococcus viridans
- Characteristics
- Gram-Positive
- Cocci
- Catalase-Negative
- Alpha-Hemolytic
- Optochin-Resistant
- Not Bile Soluble
- Normal Flora of Oropharynx
- Synthesize Dextrans from Sucrose
- Disease
- Dental Caries
- Subacute Bacterial Endocarditis
2 mins
Streptococcus Pyogenes Disease
- Pyogenic
- Pyogenic
- Pyogenic Pharyngitis
- Impetigo
- Cellulitis
- Toxigenic
- Toxic Shock-Like Syndrome
- Scarlet Fever
- Sandpaper Rash
- Strawberry Tongue
- Immunologic
- Immunologic
- Rheumatic Fever
- Antibodies to M Protein
- Acute Glomerulonephritis (Post Streptococcal Glomerulonephritis)
2 mins
Rocky Mountain Spotted Fever
- Rickettsia rickettsii
- Dermacentor Wood Tick
- Endemic to East Coast
- Fever
- Headache
- Rash Starts on Wrist and Ankle
- Rash migrates towards the trunk
- Thrombocytopenia
- Hyponatremia
- Elevated liver enzymes
59 secs
Staphylococcus aureus Characteristics
- Characteristics
- Gram-Positive
- Cocci
- Catalase-Positive
- Coagulase-Positive
- Beta-Hemolytic
- Protein A Virulence Factor
- Inhibits Phagocytosis
- MRSA
- Resistant to Beta Lactams Due to Altered Penicillin Binding Proteins (PBPs)
2 mins
Vitamin B6 (Pyridoxine)
- Pyridoxal Phosphate
- Mechanism
- Transamination
- Decarboxylation
- Glycogen Phosphorylase
- Cystathionine Synthase
- Functions
- Heme Synthesis
- Niacin Synthesis
- Neurotransmitter Synthesis
2 mins
Adenovirus
- Characteristics
- Non-enveloped
- Icosahedral
- Linear
- Double Stranded DNA
- Signs and Symptoms
- Pharyngitis
- Conjunctivitis
- Fever
- Summer Swimming
- Day Care Centers
- Acute Hemorrhagic Cystitis
- Pneumonia
1 min
Legionella Characteristics
- Characteristics
- Bacillus
- Poor Gram Stain
- Charcoal Yeast with Iron and Cysteine
- Silver Stain
- Water Sources
- Smokers and Heavy Drinkers
- Detect Antigen in Urine
2 mins
Neisseria gonorrhoeae Characteristics
- Characteristics
- Gram Negative
- Diplococci
- Chocolate Agar
- Thayer-Martin Media
- VPN
- Oxidase Positive
- Glucose Fermenting
- Pilus
- Opa Surface Protein
- Rapid Antigenic Variation
- IgA Protease
2 mins
Neisseria gonorrhoeae Disease
- Signs & Symptoms
- Dysuria
- Pelvic Inflammatory Disease (PID)
- Fitz-Hugh-Curtis Syndrome
- Neonatal Conjunctivitis
- Pharyngitis
- Septic Arthritis
- Tenosynovitis
- Pustules On Hands And Feet
- Treatment
- Ceftriaxone
- Azithromycin
- Doxycycline
- Considerations
- C5-9 Complement Deficiency (Recurrent Infections)
2 mins
Pseudomonas Aeruginosa Characteristics
- Characteristics
- Gram-Negative
- Bacillus
- Aerobic
- Pyocyanin Pigment
- Blue-green Pigment
- Grape like odor
- Non-lactose Fermenting
- Polysaccharide Capsule
- Catalase-Positive
- Oxidase-Positive
- Inactivates Elongation Factor 2
- Exotoxin A
- Endotoxin
- Water sources
3 mins
Rickettsia
- Need CoA and NAD
- Rocky Mountain spotted fever
- Typhus
- Ehrlichiosis
- Q fever
- Arthropod vector
- Fever
- Headache
- Rash
- Weil-Felix reaction
- Treatment doxycycline
1 min
Plasmodium Specific
- Malariae
- Fever Every Three Days
- Vivax/Ovale
- Fever Every Two Days
- Duffy Antigen Binding Site
- Duffy often absent in Black Population
- Primaquine treats dormant form in liver
- Falciparum
- Most severe
- Irregular Cycles
- Occludes capillaries in the brain, kidneys, and lungs
4 mins
Bacterial Endocarditis
- Signs and Symptoms
- Fever
- New murmur
- Janeway Lesions
- Splinter Hemorrhages
- Roth spots/round white spots on retina
- Osler nodes/tender lesions on finger or toe pads
- Anemia
2 mins
Influenza Virus
- Characteristics
- RNA Virus
- Orthomyxovirus
- Enveloped
- Negative Sense
- 8 Segments
- Helical
- Hemagglutinin for Viral Entry
- Neuraminidase for Virion Release
- Genetic Shift
- Reassortment of genome to cause major change
- Genetic Drift
- Minor Antigenic Mutations
- Considerations
- Reye Syndrome with Aspirin Use
- Guillain-Barre Syndrome
3 mins
Plasmodium General
- Characteristics
- Protozoa
- Malaria
- Anopheles Mosquito
- Signs and Symptoms
- Cyclic Fever
- Headache
- Anemia
- Splenomegaly
- Diagnosis
- Blood Smear
- Treatment
- Chloroquine
- Mefloquine for Resistant Types
3 mins
Syphilis TORCH
- Signs and Symptoms
- Nonspecific TORCH Symptoms
- Often Results in Stillbirth
- Hydrops Fetalis
- Saber Shins
- Notched Teeth
- Saddle Nose
- Blindness
- Deafness
- Hepatitis
3 mins
Granulomatosis with Polyangiitis (GPA) Symptoms
- Upper Respiratory Tract
- Saddle Nose
- Perforation of Nasal Septum
- Chronic Sinusitis
- Otitis Media
- Mastoiditis
- Lower Respiratory Tract
- Cough
- Dyspnea
- Hemoptysis
- Kidney
- Rapidly Progressive Glomerulonephritis
- Hematuria
- RBC Casts
2 mins
Syphilis
- Characteristics
- Treponema pallidum
- Spirochete with characteristic motility
- Signs and Symptoms
- Painless chancre
- Condylomata lata
- Generalized lymphadenopathy
- Rash on palms and soles
- Aortitis
- Gummas
- Neurosyphilis
- Argyll Robertson pupils
- Vasa vasorum
- Tabes dorsalis
- Treatment
- Penicillin
- Jarisch-Herxheimer reaction
2 mins
Meningitis Assessment
- Assessment
- Nausea and Vomiting
- Fever
- Nuchal Rigidity
- Severe Headache
- Purpura
- Seizures
- Photophobia
- Infants and Young Children
- Opisthotonus Position
- High-Pitched Cry
- Bulging Fontanel
2 mins
Meningitis Interventions
- Drug Therapy
- IV Antibiotics
- Dexamethasone
- Analgesics
- Antipyretics
- Considerations
- Closely Monitor for Increased ICP
- Bed Rest
- Preventative Vaccinations
- Droplet-Airborne Precautions
2 mins
Neisseria Meningitidis
- Characteristics
- Gram-Negative
- Diplococci
- Chocolate Agar
- Thayer-Martin Media
- VPN
- Oxidase-Positive
- Maltose Fermentation
- Glucose Fermentation
- Endotoxin
- Lipooligosaccharide (LOS) in Membrane
- Polysaccharide Capsule
- IgA Protease
- Disease
- Waterhouse Friderichsen Syndrome
- Adrenal Insufficiency
- Petechial Rash
- Treatments
- Ceftriaxone
- Rifampin Prophylaxis
5 mins
Ghon Complex
- Calcified Focus of Infection
- Hilar Lymph Nodes
- Primary Tuberculosis
- Typically in Children
1 min
HIV Prophylaxis Medications
- CD4+ < 200
- TMP-SMX
- Pneumocystis Pneumonia
- CD4+ < 100 Susceptible to Toxoplasma Gondii
- CD4+ < 50
- Mycobacterium Avium and Intracellulare
- Azithromycin If Delayed Therapy
2 mins
Foscarnet
- Indications
- CMV Retinitis
- Acyclovir-resistant HSV
- Mechanism
- Does Not Require Activation (by Viral Kinase)
- Inhibits Viral DNA Polymerase
- Pyrophosphate Analog
- Resistance through Mutated DNA Polymerase
- Side Effects
- Nephrotoxicity
- Electrolyte Abnormalities
- Hypokalemia
- Hypocalcemia
- Hypomagnesemia
2 mins
Ganciclovir
- Indications
- Cytomegalovirus (CMV)
- Immunocompromised
- Mechanism
- Guanosine Analog
- Disrupts DNA Synthesis
- Inhibits Viral DNA Polymerase
- Side Effects
- Hematologic Effects
- Nephrotoxicity
1 min
Severe Sepsis and Septic Shock Assessment
- Microthrombi
- DIC
- Decreased Oxygen Saturation
- Decreased WBC
- Oliguria
- High Output Heart Failure
- Multiple Organ Failure
2 mins
Sepsis Assessment
- Signs and Symptoms
- Systemic Infectious Process
- Fever
- Hypotension
- Change in LOC
- Increased WBC
- Shift to the Left
- Tachycardia
- Tachypnea
- Hyperglycemia
- Edema
2 mins
Bacillus Anthracis (Anthrax) Disease
- Signs and Symptoms
- Cutaneous
- Painless Black Eschar (Necrotic Lesion)
- Pulmonary
- Mediastinal Widening
- Rapidly Fatal
- Woolsorter's Disease
- Gastrointestinal
- Consuming Anthrax-infected Meat
2 mins
Bacillus Anthracis (Anthrax) Characteristics
- Characteristics
- Gram-Positive
- Spore-Forming
- D-glutamate Polypeptide Capsule
- Protective Antigen
- Lethal Toxin
- Edema Factor
- Increased cAMP
1 min
Tuberculosis Skin Mantoux Test (PPD)
- Delayed Hypersensitivity (Cell Mediated Response)
- Intradermal Injection
- Read 48-72 hours
- Positive Results
- ≥ 5 mm Induration
- Immunosuppressed
- ≥ 10 mm Induration
- High Risk Patients
- ≥ 15 mm Induration
- Considerations
- Chest X-Ray
3 mins
Human Immunodeficiency Virus (HIV) Interventions
- Interventions
- Adequate Nutrition
- Small Frequent Meals
- IV Hydration
- Emotional Support
- HIV Medications
- HAART
- Considerations
- Transmission Education
- Strict Asepsis for Invasive Procedures
- Treat Opportunistic Infections
2 mins
Human Immunodeficiency Virus (HIV) Stages
- Primary Infection
- Within 3 Weeks
- Flu-like Symptoms
- Asymptomatic Stage
- Years
- Symptomatic Stage
- CD4+ < 500
- AIDS
- Opportunistic Infections
- CD4+ < 200
2 mins
Human Immunodeficiency Virus (HIV) Assessment
- Assessment
- RNA Retrovirus
- CD4+ Helper T Cells
- Primary Infection
- Flu-like Symptoms
- Lymphadenopathy
- Symptomatic Stage
- Fatigue
- Diarrhea
- Unexplained Weight Loss
- White Spots on Tongue
- Persistent Fever
- Night Sweats
2 mins
Human Immunodeficiency Virus (HIV) Diagnosis
- HIV-1/2 Antigen/Antibody Immunoassay
- HIV-1/2 Antibody Differentiation Immunoassay
- Nucleic Acid Testing (NAT)
- Viral Load
- Polymerase Chain Reaction (PCR) in Neonates
3 mins
CSF Lab Values: Normal
- Pressure: < 20 cm H2O
- Color/Appearance: Clear or Colorless
- Proteins: < 40 mg/dL
- Lactate Dehydrogenase: 10% of Serum Level
- Cells: 0-5 Small Lymphocytes
- Glucose: 40-70 mg/dL
2 mins
Reye's Syndrome
- Cause
- Aspirin (Salicylates) to Treat Viral Illness (In Children)
- Assessment
- Cerebral Edema
- Lethargy (Decreased LOC)
- Vomiting
- Liver Failure
- Interventions
- Monitor for Increased ICP
- Mannitol (Osmitrol)
- Considerations
- No Aspirin for Children
2 mins
HIV CD4+ 500
- Signs and Symptoms
- Candida albicans (Oral Thrush)
- Kaposi's Sarcoma (HHV-8)
- Human Papillomavirus (HPV)
- Epstein-Barr Virus (Oral Hairy Leukoplakia)
3 mins
HIV CD4+ 200
- Signs and Symptoms
- Herpes Simplex Virus (HSV)
- JC Virus
- Progressive Multifocal Leukoencephalopathy (PML)
- Pneumocystis Pneumonia
- (HIV) Dementia
- Histoplasmosis
3 mins
HIV CD4+ 100
- Signs and Symptoms
- Aspergillus fumigatus
- Cryptococcus neoformans
- Candida albicans (Esophagitis)
- Mycobacterium avium complex (MAC)
- Cytomegalovirus (CMV)
- Epstein-Barr virus (EBV) B-cell lymphoma
- Toxoplasma gondii
- Cryptosporidium
- Bartonella henselae
5 mins
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