Chloramphenicol
- Bacteriostatic
- Inhibits 50S Peptidyltransferase Activity
- Meningitis
- Rocky Mountain Spotted Fever in Pregnant Women
- Anemia
- Aplastic Anemia
- Gray Baby Syndrome due to Decreased UDP-Glucuronyl Transferase
- Resistance Caused by Plasmid Encoded Acetyltransferase
Cisplatin
- Carcinomas
- Ovarian
- Bladder
- Lung
- Testicular
- Cross-Links DNA
- Ototoxicity
- Nephrotoxicity
- Treat with Amifostine and Chloride Diuresis
Clozapine (Clozaril)
- Atypical Antipsychotic
- Schizophrenia
- Levodopa-Induced Psychosis
- Weight Gain
- Hypersalivation (Sialorrhea)
- Myocarditis
- Agranulocytosis
- Sedation
- Orthostatic Hypotension
- Constipation (Risk of Bowel Ileus)
- Weekly Lab Tests
Acute Digoxin Toxicity
- Hyperkalemia
- Cholinergic (Nausea, Vomiting, Diarrhea)
- Blurry Yellow Green Vision with Halo of Light
- Arrhythmia
- Bradycardia
- Prolonged PR interval
- Decreased QT
- Scooping on EKG
- T Wave Inversion
Digoxin Toxicity Treatment
- Activated Charcoal
- Slowly Normalize K+
- Digibind (Anti-Digoxin Fab)
- Magnesium Sulfate
- Lidocaine
- Cardiac Pacing
Doxorubicin (Adriamycin)
- Solid Tumors
- Lymphomas and Leukemias
- Free Radical Production
- Intercalates DNA
- Prevents Double Helix from Sealing
- Cardiotoxicity
- Dexrazoxane Decreases Toxicity
Fluoroquinolones Antibiotics
- -floxacin
- Inhibits Topoisomerase II & IV
- Bactericidal
- Gram-negative Rods
- Pneumonia
- Gastrointestinal Infections
- Urinary Tract Infection
- Genital Infections
- Levofloxacin
- Ciprofloxacin
- Has Pseudomonas Coverage
- Avoid Polyvalent Cations
Fluoroquinolones Toxicities
- Diarrhea
- Skin Rash
- Headache
- Tendon Rupture in Adults
- Myalgias in Kids
- Damage to Cartilage
- Teratogen
- QT Prolongation
Azoles (Ketoconazole)
- "-azole" suffix
- Local and Less Serious Systemic Mycosis
- Inhibits Ergosterol Synthesis
- Inhibits P450
- Liver Dysfunction
- Inhibition of Testosterone Synthesis
Methemoglobinemia Diagnosis and Management
- Cyanosis
- Respiratory Distress
- Headache
- Lethargy
- "Chocolate-colored Blood"
- Decreased Oxygen Saturation
- Normal Partial Pressure of Arterial O2 (PaO2)
- Identify Triggers
- Methylene Blue
- Vitamin C
- Exchange Transfusion