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Pathoma: Fundamentals of Pathology (2018) | Medicine (MD/DO) School Study Aid
Hodgkin Lymphoma Pathophysiology
- Pathophysiology
- Reed-Sternberg Cells
- Binucleate
- Owl's Eyes Appearance
- CD 15 and CD 30
- B Cell Origin
- Bimodal Age Distribution
2 mins
Hodgkin Lymphoma Signs & Symptoms
- Signs and Symptoms
- Localized Single Group of Lymph Nodes
- Contiguous Spread
- Constitutional B Symptoms
- Low-Grade Fever
- Night Sweats
- Weight Loss
2 mins
Non-Hodgkin's Lymphoma Assessment
- Cause
- Lymphatic Cancer
- Non-Contiguous Spread
- B or T Cells
- Assessment
- Painless Lymphadenopathy
- Constitutional B Signs
- Night Sweats
- Fever
- Weight Loss
- Mediastinal or Abdominal Mass
- Considerations
- Older Adults
- > 60 Subtypes
2 mins
Follicular Lymphoma
- Derives from Germinal Center
- Occurs in adults
- T14;18
- BCL 2 overexpression
- BCL 2 inhibits apoptosis
- Indolent
- Generalized lymphadenopathy
- Bone marrow involvement
2 mins
Mantle Cell Lymphoma
- Older Males
- Activation of Cyclin D Gene
- T 11;14
- CD5
- Poor Prognosis
55 secs
Helicobacter Pylori
- Characteristics
- Gram-Negative
- Bacilli
- Curved
- Polar Flagellum
- Catalase-Positive
- Oxidase-Positive
- Disease
- Gastric and Duodenal Ulcers
- Ammonia
- Neutral Environment
- Gastric Adenocarcinoma
- MALT lymphoma
- Diagnosis
- Serology IgG antibody
- Stool Antigen
- Urease Positive Breath Test
- Biopsy
- Treatment
- 2 ABX and PPI
2 mins
Chronic Gastritis
- Type A
- Type A
- Fundus and Body
- Autoimmune
- Autoantibodies to Parietal Cells
- Pernicious Anemia
- Achlorhydria
- Type B
- Type B
- Most Common Type
- Helicobacter pylori
- Antrum
- Increased Risk of MALT Lymphoma
- Associations
- HIV/AIDS
- Crohn's Disease
3 mins
Hashimoto's Thyroiditis
- Symptoms
- Hypothyroidism with Bouts of Hyperthyroidism
- Enlarged, Nontender Thyroid
- Mechanism
- Autoimmune
- Anti-Thyroid Peroxidase (TPO)
- Anti-Thyroglobulin
- Lab Findings
- Hurthle Cells
- Lymphoid Follicles
- Associations
- HLA-DR5 and HLA-DR3
- Increased Risk Of Non-Hodgkin Lymphoma
2 mins
Burkitt's Lymphoma
- Adolescents or young adults
- C-myc gene moves next to heavy chain Ig gene
- T 8;14
- Starry sky appearance
- Sheets of lymphocytes with interspersed macrophages
- Jaw lesion in endemic (African) form
- Pelvis or abdomen in non endemic form (American form)
- Associated with EBV
2 mins
Diffuse Large B Cell Lymphoma
- Epidemiology
- Most Common Non-Hodgkin’s Lymphoma
- Usually in Older Adults
- 20% in Children
- Features
- May be Mature T Cell in Origin
- Derives from Germinal Center
- GI Tract and Brain
2 mins
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